JaeHwan Lee
Seoul National University
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Featured researches published by JaeHwan Lee.
Bioscience, Biotechnology, and Biochemistry | 2009
Seung-Ok Yang; So-Hyun Kim; Sayeon Cho; JaeHwan Lee; Young-Suk Kim; Sung-Seob Yun; Hyung-Kyoon Choi
Changes in metabolites in fermented soymilk prepared with selected Bifidobacterium and Streptococci strains were analyzed using a 1H-NMR-based metabolomic technique. Principal components analysis (PCA) allowed the clear separation of 50% methanol extracts from fermented soymilk with different fermentation times by combining principal components PC1 and PC3, which accounted for 55.1% of the total variance. Loading plot analysis was performed to select major compounds contributing to the separation, and the relative levels of selected metabolites were determined. In addition, the free-radical scavenging activities of each sample were investigated, and the underlying mechanisms were elucidated by determining the total phenolics and total flavonoids contents of each sample. The present study suggests the usefulness of combining 1H-NMR with PCA in discriminating fermented soymilk samples with different fermentation times, and elucidates of the factors affecting free-radical scavenging activities of fermented soymilk.
New Biotechnology | 2010
Kyung Min Park; Oh Taek Kwon; Seon Min Ahn; JaeHwan Lee; Pahn-Shick Chang
Calotropis procera R. Br. carboxylesterase (EC 3.1.1.1) solubilized in reversed micellar glycerol droplets containing a very small amount of water (less than 5ppm) and stabilized by a surfactant effectively catalyzed the esterification between glycerol and capric acid to produce 1-monocaprin. Reaction variables including surfactant types, organic solvent media, reaction time, G-value ([glycerol]/[capric acid]), R-value ([water]/[surfactant]), pH, temperature, and types of metal ion inhibitors on the carboxylesterase-catalyzed esterification were characterized and optimized to efficiently produce 1-monocaprin. Bis(2-ethylhexyl) sodium sulfosuccinate (AOT) and isooctane were the most effective surfactant and organic solvent medium, respectively, for 1-monocaprin formation in reversed micelles. The optimum G- and R-values were 3.0 and 0.05, respectively, and the optimum pH and temperature were determined to be 10.0 and 60 degrees C, respectively. K(m,app.) and V(max,app.) were calculated from a Hanes-Woolf plot, and the values were 9.64 mM and 2.45 microM/min mg protein, respectively. Among various metal ions, Cu(2+) and Fe(2+) severely inhibited carboxylesterase-catalyzed esterification activity (less than 6.0% of relative activity).
Kidney & Blood Pressure Research | 2017
Hyun Hoon Chung; JaeHwan Lee; Eujin Park; Hyesun Hyun; Yo Han Ahn; Hwan Jun Jae; Gi Beom Kim; Il Soo Ha; Hae Il Cheong; Hee Gyung Kang
Background/Aims: Renovascular hypertension (RVHT) is an important cause of childhood hypertension. This study evaluated the clinical characteristics and outcomes of Korean children with RVHT. Methods: Children treated for RVHT between 2000 and 2015 at our center were retrospectively reviewed. Results: Forty-six children were followed for a median of 6.5 (0.66-27.23) years. Forty-five percutaneous transluminal angioplasties (PTAs) were performed in 32 children. At the last visit, clinical benefit was observed in 53.3% of children. Patients with comorbid cerebrovascular disease (CVD) showed less favorable long-term outcomes after PTA (clinical benefit in 41.7% vs. 61.1% in others) and higher restenosis rates (50% vs. 31.6% in others). Surgical procedures (bypass or nephrectomy) were performed in 8 patients. After surgery, blood pressure was normalized in 2 patients, improved in 3 patients, and unchanged in the remaining patients. Between PTA group (n=21) and medication group (n=14), percentage of atrophic kidneys became higher after follow-up period in medication group than in PTA group (60.0% vs. 26.1%, P=0.037). Conclusion: Aggressive treatment of pediatric RVHT yielded fair outcomes in our cohort. CVD comorbidity was associated with relatively poor PTA outcomes. To confirm our findings, larger cohort studies with a longer follow-up period are warranted.
Food Chemistry | 2007
JaeMin Lee; Hyun Hoon Chung; Pahn-Shick Chang; JaeHwan Lee
Food Chemistry | 2010
Seung Wook Lee; Min Kyu Jeung; Min Hee Park; Soo Yong Lee; JaeHwan Lee
Food Chemistry | 2009
Seung-Wook Lee; JaeHwan Lee
Journal of Agricultural and Food Chemistry | 2003
JaeHwan Lee; Raymond Diono; Gur-Yoo Kim; David B. Min
Food Chemistry | 2007
JaeMin Lee; Dong-Hwan Kim; Pahn-Shick Chang; JaeHwan Lee
Food Chemistry | 2010
Young Woo Park; Pahn-Shick Chang; JaeHwan Lee
Journal of Agricultural and Food Chemistry | 2003
Gur-Yoo Kim; JaeHwan Lee; David B. Min