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Dive into the research topics where Jagannath P is active.

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Featured researches published by Jagannath P.


Gastrointestinal Endoscopy | 1994

Diagnosis of malignant obstructive jaundice by bile cytology: Results improved by dilating the bile duct strictures ☆ ☆☆ ★ ★★ ♢

Mohandas Km; V. Santhi Swaroop; S.U. Gullar; U.R. Dave; Jagannath P; Desouza Lj

The disruption of malignant biliary strictures by dilation could enhance the results of bile cytology. To test this hypothesis, we studied the results of bile cytology in 64 consecutive patients undergoing endoscopic biliary drainage for malignant biliary strictures. Patients included 36 men and 28 women, ages 29 to 79 years. In the control group (n = 15), bile was obtained by aspiration without dilating the biliary stricture. In the dilated group (n = 49), bile was aspirated after dilating the biliary stricture to 10F gauge. The bile was centrifuged, and smears were prepared, stained, and interpreted as malignant, suggestive of malignancy, or not malignant. The biliary obstruction was caused by gallbladder cancer in 33, primary bile duct cancer in 14, pancreatic cancer in 11, and metastasis in 6 patients. Forty patients had obstruction at the bifurcation of the hepatic duct. Malignancy was confirmed by surgery in 14, fine-needle aspiration cytology in 9, presence of metastasis in 19, and a combination of clinical and radiologic studies, endoscopic cholangiopancreatography findings, elevated tumor markers, and follow-up in 22 patients. Bile cytology was positive for malignancy in 4 (26.6%) and 31 (63.3%), suggestive in 1 (6.7%) and 6 (12.2%), and negative in 10 (66.7%) and 12 (24.5%) patients in the control group and the dilated group, respectively (p = 0.028, 95% CI 1.15 and 21.03). Cytology was positive in 73% of gallbladder cancers, 62.5% of bile duct cancers, 40% of pancreatic cancers, and 60% of metastasized cancers after dilation. Two patients had hemobilia, 8 had cholangitis, and 2 had pancreatitis after biliary drainage.(ABSTRACT TRUNCATED AT 250 WORDS)


Journal of Surgical Oncology | 1996

Primary carcinoid tumor of the liver: Report of four resected cases including one with gastrin production

Shanta Krishnamurthy; Vibha Dutta; Sanjay A. Pai; Shubhada Kane; Jagannath P; Luzito J. Desouza; Ramakant K. Deshpande; P. B. Desai

Four cases of primary hepatic carcinoid were identified during a retrospective study of liver resections for primary tumor. The cases included two adult males, one adult female, and a 9‐year‐old boy in whom gastrin levels were documented. The estimation of gastrin levels was prompted by symptoms suggestive of acid‐peptic disease. One patient died postoperatively. The other three are alive and well at 3 years, 2 years, and at 1 year, respectively, after surgery, outcomes distinctly different from hepatocellular carcinomas. Diagnostic difficulties may be experienced in histologic assessment, and this may require recourse to immunohistochemistry and electron microscopy. Long‐term follow‐up and careful exclusion of a possible primary elsewhere are necessary for establishing the primary nature of liver carcinoids.


Hpb | 2003

Pancreatic tuberculosis: an elusive diagnosis

C.S. Pramesh; A.A. Heroor; S.G. Gupta; S. Krishnamurthy; Parul J. Shukla; Jagannath P; Desouza Lj

Background Pancreatic tuberculosis is a rare disease. Its presenting features are usually vague and non‐specific, while the radiological features mimic pancreatic malignancy in many cases and pancreatitis in others. Ultrasound‐ or CT‐guided fine‐needle aspiration cytology (FNAC) or biopsy may show caseating granulomatous inflammation but microbiological confirmation may not always be possible. Laparotomy may be required if other investigations prove inconclusive. The response to treatment is good. Case outlines We report two young men with pancreatic tuberculosis. The diagnosis was obtained by FNAC in one and laparotomy in the other. Each patient responded to anti‐tuberculous chemotherapy and is now asymptomatic. Conclusion Tuberculosis should be considered in the differential diagnosis of an obscure pancreatic mass, and the condition is readily curable.


Future Oncology | 2015

Neoadjuvant chemotherapy in patients with locally advanced gallbladder cancer

Bhawna Sirohi; Abhishek Mitra; Jagannath P; Ashish Singh; Mukta Ramadvar; Suyash Kulkarni; Mahesh Goel; Shailesh V. Shrikhande

AIM Surgery is the only curative option for patients with gallbladder cancer (GBC). This study looks at the outcome of patients treated with neoadjuvant chemotherapy (NACT). PATIENTS & METHODS This is retrospective analysis of the prospectively maintained database of patients with locally advanced GBC treated between February 2009 and September 2013 with NACT. Patients received gemcitabine-platinum based regimen. RESULTS A total of 37 patients (median age: 54 years, 64.9% females) received NACT. Overall response rate was 67.5%. In total, 17 patients (46%) underwent R0 resection. Median overall survival/progression-free survival of the whole group was 13.4/8.1 months, respectively. Patients who underwent surgery had a significantly better overall survival (median not reached vs 9.5 months) and progression-free survival (25.8 vs 5.6 months), respectively. CONCLUSION NACT increases resectability and survival in patients with locally advanced GBC.


Anz Journal of Surgery | 2005

Reoperative pancreaticoduodenectomy for periampullary carcinoma

Parul J. Shukla; Sajid S. Qureshi; Shailesh V. Shrikhande; Jagannath P; Desouza Lj

Background:  Potentially resectable periampullary tumours may not be treated appropriately due to lack of local expertise in both assessment of resectability and resection in referring centres. Tata Memorial Hospital is a major referral centre for oncology and these patients are finally referred to this institution. In carefully selected patients, resection can be accomplished. The purpose of the present paper was to determine the perioperative morbidity and mortality for patients undergoing reoperative pancreaticoduodenectomy at a major comprehensive cancer centre.


International journal of hepatology | 2012

Surgical Treatment of Liver Metastases in Neuroendocrine Neoplasms

Jagannath P; Deepak Chhabra; Shailesh V. Shrikhande; R. Shah

Neuroendocrine neoplasms (NENs) are a distinctive entity, and nearly 10% of patients already have liver metastases at presentation. The management of neuroendocrine liver metastases (NEN-LM) is complex with differing patterns of metastatic presentation. An aggressive approach should be used to resect the primary tumor, to remove regional lymph nodes, and to resect or treat appropriate distant metastases (including liver tumors). Despite having an indolent course, NENs have a significantly reduced survival when liver metastases are untreated. Though a wide range of therapies are now available with a multimodal approach to the treatment, surgical treatment offers the only chance for a significant survival prolongation and/or improvement of symptoms and quality of life. A review of the existing surgical modalities for NEN-LM is discussed in this paper.


Indian Journal of Clinical Biochemistry | 2001

Leucine amino peptidase a better indicator of carcinoma of liver, biliary tract and pancreas.

M. S. Ghadge; A. V. Sirsat; M. S. Bhansali; Desouza Lj; Jagannath P

Serum levels of leucine amino peptidase (LAP) was studied along with bilirubin, aspartate transaminase (AST), alanine transaminase (ALT), gamma glutamyl transpeptidase (GGT), alkaline phosphatase (ALP) and the ratio of AST/ALT and GGT/AST in 25 healthy subjects and 52 patients with hepatobiliary malignancies of which 12 were with hepatocellular carcinoma, 12 with liver metastasis, 6 with obstructive jaundice, 9 with carcinoma of gall bladder, 6 with carcinoma of pancreas and 7 with periampullary carcinoma. 24 Of the 52 patients studied had jaundice and 28 were without jaundice.LAP as compared to the other enzymes AST, ALT, GGT, ALP and AST/ALT ratio and GGT/AST ratio showed 100% elevation in obstructive jaundice, carcinoma of gall bladder and pancreas and periampullary carcinoma, 91.7% elevation in hepatocellular carcinoma and 83.3% elevation in liver metastasis. On comparing the levels of these enzymes in non jaundiced and jaundiced groups, LAP was elevated in both jaundiced and non jaundiced groups in 95.8% and 92.9% cases respectively whereas the other enzymes AST showed increase from 67.9% to 100%, ALT from 21.4% to 83.3%, GGT from 71.4% to 95.4% and ALP from 82.1% to 100% in non jaundiced and jaundiced groups respectively indicating that LAP rises in hepatic dysfunction due to hepatobiliary malignancy whereas the other liver function enzymes showed increased hepatic dysfunction due to hepatobiliary malignancy with the onset of jaundice thereby indicating that LAP is a better indicator of hepatobiliary malignancy as compared to other enzymes.The quantitative methods used for determination are reliable, accurate, simple, rapid and cost effective and therefore have better application in a clinical setting.


Journal of Gastrointestinal Cancer | 2018

Pancreaticoduodenectomy with Replaced Common Hepatic Artery and Portal Vein Reconstruction in Primary Carcinoma Duodenum: a Case Report and Literature Review.

Gunjan Desai; Prasad Pande; R. Shah; Jagannath P

The role of combined arterial and superior mesenteric-portal venous resection and reconstruction is not established in primary duodenal carcinoma [1, 2]. Arterial resections tend to result in high morbidity [2]. We present here a case of primary duodenal carcinoma wherein a combined vascular resection and primary repair was performed, along with the possible selection criteria for this procedure and a brief literature review.


Indian Journal of Clinical Biochemistry | 1996

Studies on serum amylases in carcinoma of liver, biliary tract and pancreas

M. M. Khanolkar; A. V. Sirsat; M. S. Bhansali; Jagannath P; Desouza Lj

Total amylase activity, its isoenzymes and pancreatic to salivary ratio were studied in 33 healthy subjects and 52 patients with hepatobiliary and pancreatic malignancies of which 12 were with hepatocellular carcinoma, 12 with liver metastases, 9 with carcinoma of gall bladder, 6 with obstructive jaundice, 7 with periampullary carcinoma and 6 cases with carcinoma of pancreas.Total amylase was found to be elevated in carcinoma of pancreas and periampullary carcinoma compared to normal whereas in obstructive jaundice the values were decreased significantly (p<0.001). P (Pancreatic) fraction was found to be elevated significantly in all except in carcinoma of pancreas and obstructive jaundice. S (Salivary) fraction was decreased significantly in all except in carcinoma of pancreas. P/S ratio was elevated in hepatocellular carcinoma, obstructive jaundice, metastatic liver disease, gall bladder carcinoma and periampullary carcinoma (p<0.001) but in carcinoma of pancreas P/S ratio was low as compared to normal.This simple test of total serum amylase, P fraction and S fraction, P/S ratio can be utilised in differentiating various hepatobiliary and pancreatic malignancies.


Indian Journal of Gastroenterology | 1997

Precut papillotomy using a needle knife: experience in 100 patients with malignant obstructive jaundice.

Dhir; Swaroop Vs; Mohandas Km; Jagannath P; Desouza Lj

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Desouza Lj

Tata Memorial Hospital

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Mohandas Km

Tata Memorial Hospital

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Swaroop Vs

Tata Memorial Hospital

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Dhir

Tata Memorial Hospital

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Nagral A

Tata Memorial Hospital

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Wagle Sd

Tata Memorial Hospital

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