Jahyo Kang

(−)-α-Isosparteine as a chiral ligand in asymmetric allylic alkylation

Abstract The cationic complex [Pd(π-Allyl(Isosparteine)] + PF 6 was found to be a suitable catalyst for asymmetric alkylation of allylic acetates. Asymmetric allylic alkylation with NaCH(CO 2 Me) 2 , was carried out in the presence of a 5 mol % of the catalyst to give chiral alkylation products with high enantiomeric excesses.

Activation of methylenetriphenylphosphorane by reaction with t-butyl- or sec-butyllithium

Abstract Experimental details are provided to support a previous report that α-methylenetriphenylphosphorane ( 1 ) may be activated for reaction with unreactive substrates such as epoxides and hindered ketones by α-metallation to 2 .

Short, stereocontrolled syntheses of irreversible eicosanoid biosynthesis inhibitors. 5,6- , 8,9- , and 11,12-dehydroarachidonic acid

Abstract 5,6- and 11,12-dehydroarachidonic acids ( 1 and 3 ), which irreversibly inhibit leukotriene and prostaglandin biosynthesis, respectively, have been synthesized, along with the 8,9-isomer ( 2 ), by novel and direct routes.

The effect of face-blocking in the enantioselective aza-Claisen rearrangement of allylic imidates

Abstract A new cobaltocenyl oxazoline palladacycle compound was prepared for the enantioselective aza-Claisen rearrangement of allylic imidates. Studies on the effect of face-blocking and the mechanism of the reaction were carried out.

Total synthesis of 12-(S)-10-hydroxy-trans-11,12-epoxyeicosa-5,9,14-(Z)-trienoic acids, metabolites of arachidonic acid in mammalian blood platelets

Abstract The two isomeric hydroxy-11,12-epoxides produced from arachidonic acid in mammalian blood platelets have been identified by comparison with totally synthetic substances as the C(10)-diastereomers of 2 .