Jai-Il Youn

Time course of ultraviolet-induced skin reactions evaluated by two different reflectance spectrophotometers: DermaSpectrophotometer and Minolta spectrophotometer CM-2002.

Backgrounds: Many attempts have been made to quantify ultraviolet (UV)‐induced erythema and pigmentation, but most studies have been focused on the initial changes of reaction for a few hours or days and neglected the later events.

Positive effect of using calcipotriol ointment with narrow‐band ultraviolet B phototherapy in psoriatic patients

Background/purpose: The successful use of narrow‐band ultraviolet B (UVB) phototherapy for the management of psoriasis has prompted the examination of various combination treatments with narrow‐band UVB. However, there have been contradictory reports on the effect of the calcipotriol–narrow‐band UVB combination. This study was performed to compare the clinical efficacy of the calcipotriol–narrow‐band UVB combination with narrow‐band UVB alone.

The difference between the constitutive and facultative skin color does not reflect skin phototype in Asian skin

Background/purpose: The assessment of the sensitivity of human skin to ultraviolet (UV) radiation is important in the area of phototherapy, photodermatoses, photo‐aging, photo‐carcinogenesis, and photo‐protection. Some reports have shown that quantitatively measured skin color is a good indicator for predicting UV sensitivity to human skin in Caucasians. In this study, our aim was to define the correlation between skin color and the skin phototype assessed by the Fitzpatrick method in Asian brown skin.

GM-CSF production by epithelial cell line: upregulation by ultraviolet A.

It was demonstrated that UVB increases synthesis and expression of IL‐1α and GM‐CSF by keratinocytes. Upregulation of GM‐CSF by UVB is reported to be mediated by IL‐1α. However, regulation of IL‐1α and GM‐CSF by UVA is not well‐known. The purpose of the present study was to evaluate the effects of UVA on IL‐1α and GM‐CSF production. Here we used a competitive RT‐PCR for measuring cytokine gene expression in an epidermal cell line after UVA irradiation. IL‐1α and GM‐CSF mRNA did not show any change at 1 h and 6 h following exposure to UVA. After UVA irradiation, however, IL‐1α mRNA decreased and GM‐CSF mRNA increased at 24 h and the level of GM‐CSF in culture supernatant increased at 24 h and 48 h. Addition of antihuman IL‐1α neutralizing antibody to UVA irradiated cells did not prevent the increase of GM‐CSF mRNA expression. These results suggest that UVA radiation may induce GM‐CSF production through an IL‐1α independent pathway.

Quantitative assessment of narrow-band UVB induced tanning during phototherapy in korea

Background/Purpose: Narrow‐band (TL‐01) UVB lamps are being increasingly used for phototherapy of psoriasis and other dermatoses, for their excellent effect compared with broad‐band UVB sources. Many patients receiving phototherapy have complained about the tanning effect of ultraviolet radiation especially in dark‐skinned ones. So we wished to know the degree of pigmentation induced by phototherapy during narrow‐band UVB treatment.

Comparative quantitative analysis of ultraviolet B-induced skin blood flow change using laser Doppler perfusion imaging technique.

Laser Doppler perfusion imaging (LDI), recently developed, can generate a color‐coded image of tissue perfusion, making it possible to assess the spatial distribution of skin perfusion without touching the surface. Using this apparatus, we investigated ultraviolet B (UVB)‐induced perfusion profile of the skin and compared the results with those obtained from laser Doppler flowmetry (LDF). Fifteen adult male Korean volunteers were irradiated with several doses of UVB ranging from 25 mJ/cm2 to 186 mJ/cm2. Twenty‐four hours later, the erythema reaction was evaluated with LDF and LDI systems. There was a significant correlation between the logarithmic dose of UVB and erythema values. The curves consisted of two parts, an initial, flat phase and then a linear, steep one. Also, there was a good correlation between LDF and LDI. The LDI is as sensitive as conventional LDF, but has the many advantages of measuring blood flow over large areas without contact with the skin surface. This instrument will be useful in the measurement of skin blood flow in many areas of dermatological application.

Analysis of the number of enlarged pores according to site, age, and sex

Increasing the number of enlarged pores causes cosmetic problems. The difference in the number of enlarged pores according to facial site, age, and sex is unclear.

Disseminated tuberculosis following adalimumab treatment in psoriasis despite negative screening

Tumor necrosis factor (TNF) a plays an important pathogenic role in psoriasis and other immune-mediated diseases. The introduction of anti-TNFa therapy is a new strategy in the treatment of these chronic diseases and can markedly improve patients’ quality of life. Anti-TNFa agents can be used relatively safely, but some patients experience susceptibility to infection as an adverse effect. The most common infections were upper respiratory tract infections, rhinitis, and urinary tract infections. Moreover, the risk of active TB was reported to be 4-fold higher in treated patients than in the general population. On average, TB was diagnosed after 4 months of treatment with an anti-TNFa agent, and most of these cases were thought to be a reactivation of latent TB. There have been case reports of active tuberculosis (TB) developing during treatment with adalimumab despite screening for active and latent TB before medication. We report a case of disseminated TB developing after 7 months of adalimumab

Accuracy and Reliability of Subjective Answer about Age of Onset in Psoriasis

112 Ann Dermatol Received February 10, 2015, Revised December 22, 2016, Accepted for publication February 1, 2017 Corresponding author: Jai-Il Youn, Department of Dermatology, National Medical Center, 245 Eulji-ro, Jung-gu, Seoul 04564, Korea. Tel: 82-2-2260-7315, Fax: 82-2-2277-0915, E-mail: nmcderma@hanmail.net This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/ licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright

Association of Hepatitis B Virus Infection and Psoriasis

822 Ann Dermatol Received October 27, 2016, Accepted for publication November 28, 2016 Corresponding author: Jai-Il Youn, Department of Dermatology, National Medical Center, 245 Eulji-ro, Jung-gu, Seoul 04564, Korea. Tel: 82-2-2060-7315, Fax: 82-2-2277-0915, E-mail: nmcderma@daum.net This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons. org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright