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Featured researches published by Jakob M. Bogenberger.


Cancer Research | 2005

Multiple Roles for the Receptor Tyrosine Kinase Axl in Tumor Formation

Sacha J. Holland; Mark Powell; Christian Franci; Emily Chan; Annabelle M. Friera; John R. McLaughlin; Susan E. Swift; Erlina Pali; George C. Yam; Stephen T. C. Wong; Joe Lasaga; Mary R. Shen; Simon C.H. Yu; Weiduan Xu; Yasumichi Hitoshi; Jakob M. Bogenberger; Jacques E. Nör; Donald G. Payan; James B. Lorens

A focus of contemporary cancer therapeutic development is the targeting of both the transformed cell and the supporting cellular microenvironment. Cell migration is a fundamental cellular behavior required for the complex interplay between multiple cell types necessary for tumor development. We therefore developed a novel retroviral-based screening technology in primary human endothelial cells to discover genes that control cell migration. We identified the receptor tyrosine kinase Axl as a novel regulator of endothelial cell haptotactic migration towards the matrix factor vitronectin. Using small interfering RNA-mediated silencing and overexpression of wild-type or mutated receptor proteins, we show that Axl is a key regulator of multiple angiogenic behaviors including endothelial cell migration, proliferation, and tube formation in vitro. Moreover, using sustained, retrovirally delivered short hairpin RNA (shRNA) Axl knockdown, we show that Axl is necessary for in vivo angiogenesis in a mouse model. Furthermore, we show that Axl is also required for human breast carcinoma cells to form a tumor in vivo. These findings indicate that Axl regulates processes vital for both neovascularization and tumorigenesis. Disruption of Axl signaling using a small-molecule inhibitor will hence simultaneously affect both the tumor and stromal cell compartments and thus represents a unique approach for cancer therapeutic development.


Journal of Biological Chemistry | 1995

Cloning and Characterization of the Human Megakaryocyte Growth and Development Factor (MGDF) Gene

Ming-Shi Chang; Jennifer McNinch; Rita Basu; John R. Shutter; Rou-yin Hsu; Chris Perkins; Vernon Mar; Sid Suggs; Andy Welcher; Luke Li; Hsieng S. Lu; Tim Bartley; Pam Hunt; Frank Martin; Babru Samal; Jakob M. Bogenberger


Archive | 1995

Compositions and methods for stimulating megakaryocyte growth and differentiation

Timothy D. Bartley; Jakob M. Bogenberger; Robert A. Bosselman; Pamela Hunt; Olaf B. Kinstler; Babru Samal


Archive | 1995

Method for treating mammals with monopegylated proteins that stimulates megakaryocyte growth and differentiation

Timothy D. Bartley; Jakob M. Bogenberger; Robert A. Bosselman; Pamela Hunt; Olaf B. Kinstler; Babru Samal


Archive | 1994

Mono-pegylated proteins that stimulate megakaryocyte growth and differentiation

Timothy D. Bartley; Jakob M. Bogenberger; Robert A. Bosselman; Pamela Hunt; Olaf B. Kinstler; Babru Samal


Archive | 2005

Modulators of angiogenesis

James Lorens; Weiduan Xu; Jakob M. Bogenberger


Archive | 2003

CASPR3: modulators of angiogenesis

James B. Lorens; Weiduan Xu; Jakob M. Bogenberger


Archive | 2002

Bi-directionally cloned random cDNA expression vector libraries, compositions and methods of use

James B. Lorens; Jakob M. Bogenberger


Archive | 2001

In vitro transcribed retroviral genomes, methods for their production and methods of use

Jakob M. Bogenberger; James B. Lorens; Susan E. Swift


Archive | 2005

RNAse probe protection assays in screening for modulators of immunoglobulin germline transcription

Susan E. Swift; Jakob M. Bogenberger

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