Jakub Pawlikowski

Population biobanking in selected European countries and proposed model for a Polish national DNA bank

Population biobanks offer new opportunities for public health, are rudimentary for the development of its new branch called Public Health Genomics, and are important for translational research. This article presents organizational models of population biobanks in selected European countries. Review of bibliography and websites of European population biobanks (UK, Spain, Estonia). Some countries establish national genomic biobanks (DNA banks) in order to conduct research on new methods of prevention, diagnosis and treatment of the genetic and lifestyle diseases and on pharmacogenetic research. Individual countries have developed different organizational models of these institutions and specific legal regulations regarding various ways of obtaining genetic data from the inhabitants, donors’ rights, organizational and legal aspects. Population biobanks in European countries were funded in different manners. In light of these solutions, the authors discuss prospects of establishing a Polish national genomic biobank for research purpose. They propose the creation of such an institution based on the existing network of blood-donation centres and clinical biobanks in Poland.

The analysis of the ethical, organizational and legal aspects of Polish biobanks activity

BACKGROUND Biobanks create new opportunities for the public health (Public Health Genomics) but need some regulations. Polish biobanks are in the phase of dynamic transformations aiming at integrating their activity and adjusting them to the international standards. The aim of this article is to present the current standards held in the most important Polish institutions collecting biological samples. METHODS A survey was conducted by the questionnaire filled by managers and directors of 24 Polish biobanks. Questions concerned obtaining patient informed consent (also a consent to some future researches and access to dates by other organizations), protection of privacy, storage of the samples and the relevant information, the opinion related to the need of establishing Polish national DNA data bank and possibilities of the scientific international cooperation. RESULTS The written consent to carry out research on the samples is obtained almost everywhere, but 29% of biabanks does not acquire the consent for the future usage of the samples. Almost all inquired banks (93%, n = 22) declare the willingness to start an international cooperation. Most of respondents support the idea of establishing the Polish national DNA bank by the fusion of the already existing banks. CONCLUSION The inquiry findings point that the current biobanks procedures do not differ to any relevant degree from procedures applied in the West European countries. Many of Polish biobanking organizations are willing to cooperate with foreign sites. It may enhance the European biobanking network and gene-environmental research.

Biobank research and ethics: the problem of informed consent in Polish biobanks

Introduction The dynamic development of biobanks causes some ethical, social, and legal problems. The most discussed problems are obtaining informed consent, especially for future research, from minors and from deceased people. The aim of this article is to present the current standards held by Polish biobanks concerning obtaining a participants informed consent in some aspects. Material and methods Survey was carried out by anonymous questionnaire among 59 institutions which deal with the collecting and storage of human cells and tissues in the year 2008. Twenty four filled-in copies of the questionnaires were sent back (return=41%). Results Almost every institution (92%) obtains written consent, but a third of the surveyed institutions (29%) do not obtain consent for the future use of the samples. The majority of the respondents (83%) support the idea of using biological materials for research purposes of a donor who died if he did not leave any written objection to such practices and 46% of respondents stated that biobanks should obtain the consent from the already mature donor who gave their samples as a child. Conclusions The practice and rules for obtaining informed consent for the scientific research require improvement. The possibility to use the human materials in the future, conditions for getting access to the data, the possibility of their withdrawal from the database and using the materials and data after the death of the donor should be clearly determined when the informed consent to collect the material is obtained.

Leprosy: Social implications from antiquity to the present

One of the most important dermatologic diseases from the sociologic viewpoint has been leprosy. Those with leprosy were isolated, excluded from society, and stigmatized. Such a stigma indicates the strong feeling that a leprosy patient is shameful and should not be accepted by society. During the first millennium, leprosy was rapidly inscribed in the system of religious prohibitions-the disease was a punishment by God for wrongdoing, and the disease was associated with the lower spheres of the society. Social perception of leprosy gradually changed during the time of Crusades. The care for lepers became a Christian obligation, and celebrating Holy Masses as for the dead was forsaken. The sick were forced to stay at leprosaria, particularly from the 14th through the 19th centuries when fear of leprosy was at a high point. Admission to a leprosarium was mandatory not only for patients with leprosy but also even those suspected of having the disease.

500 th anniversary of the birth of the precursor of modern cardiology: Josephus Struthius Polonus (1510–1568

In this article, the authors take a closer look at the figure of Josephus Struthius Polonus (1510- -1568), one of the most famous physicians of the European Renaissance, on the 500(th) anniversary of his birth. Struthius became famous for his critical analysis of Galens works and his own research into the circulatory system. The analysis of Struthiuss scientific achievements leads to a conclusion that he was one of the pioneers of modern cardiology. He was a precursor of William Harvey (1578-1657) in studying the cardiovascular system, and the first person in the history of European medicine to present the pulse in a graphic form. He also presented similar ideas to those proposed in the 19(th) century by the inventor of the sphygmograph Karl von Vierodt (1818-1884), and the inventor of the polygraph Sir James Mackenzie (1853-1925).

A brief report on the history of phototherapy

From ancient times, light has played a significant role in the treatment of diseases. The modern discoveries (eg, ultraviolet radiation) and modern inventions (eg, the electric generator or the electric lightbulb), as well as balneologic experiences of the treatment with sunlight, contributed to the transition from heliotherapy to artificial light phototherapy at the end of the 19th century. Nils Ryberg Finsen (1860-1904) was the founder of modern phototherapy. He is famous for applying an electric carbon arc torch in treating patients with lupus vulgaris using ultraviolet radiation. Subsequently, phototherapy using artificial light sources gained importance in the treatment of skin diseases with a noninfectious etiology. William Henry Goeckerman (1884-1954) chose an ultraviolet B light to treat psoriasis. Improvement in the effectiveness of dermatologic phototherapy occurred in 1947, when methoxypsoralen was isolated. During the 20th century, phototherapy was applied to new therapeutic areas, such as neonatology, psychiatry, and ophthalmology.

DNR declaration — emergency medical system nurses’ opinions

Advance directive and other declarations of will made by patients in a case of mental illness still raise ethical and legal issues. In Poland there is no legal regulation, neither research about code of conduct in situation of do not attempt resuscitation. There are also not enough studies regarding Healthcare workers’ opinion about DNAR declaration (Do Not Attempt Resuscitation). The study is aimed at finding out emergency medical system nurses opinion on the subject of enforcing do not attempt resuscitation in situation of circulatory and respiratory arrest. Methods: The research was conducted by means of the diagnostic survey method applying a self — constructed questionnaire. The study was carried out among 82 (100%) nurses, from September to December 2011. Obtained information were analyzed statistically, Chi-square of independence with assumed p ≤ 0.05. level of significance was used for statistical analysis. Results: The study of the respondents’ opinion shows that 67% Healthcare employees think that DNAR declaration should be obligatory in Poland. Contrary opinion has 7.3% of respondents. In their opinion the decision to refrain from resuscitating should be made by attending physician − 46.3% and medical board − 29.3%. Information enclosed within DNAR declaration, in most of respondents’ opinion − 59.5%, should be only passed on in written form. Conclusions: Majority of respondents agree that patients have a right to refrain from resuscitating as a self − determination act. Respondents concur the introduction of DNAR declaration in Polish Healthcare system. In respondents’ opinion that decision should be required in written form and an attending physician should decide about its implementation, what violates the existing rule. The execution of living will declaration raises ethical issues. Additionally, it also appears as public/social problem. The last stage of incurable disease is given as justifiable circumstances of DNAR.

Familiarity and understanding of patients’ religiosity and faith influence the level of comfort nurses and care workers feel when providing care

Commentary on : Skomakerstuen Odbehr L, Kvigne K, Hauge S, et al. A qualitative study of nurses’ attitudes towards and accommodations of patients’ expressions of religiosity and faith in dementia care. J Adv Nurs 2015;71:359–69.[OpenUrl][1][CrossRef][2][PubMed][3] A lot of the research published during the last two decades has indicated the insufficiency of the biopsychosocial model and has suggested adding a spiritual dimension to it. This especially concerns elderly patients with chronic diseases, as they may need … [1]: {openurl}?query=rft.jtitle%253DJ%2BAdv%2BNurs%26rft.volume%253D71%26rft.spage%253D359%26rft_id%253Dinfo%253Adoi%252F10.1111%252Fjan.12500%26rft_id%253Dinfo%253Apmid%252F25092229%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/external-ref?access_num=10.1111/jan.12500&link_type=DOI [3]: /lookup/external-ref?access_num=25092229&link_type=MED&atom=%2Febnurs%2F19%2F2%2F63.atom

Impact of beliefs about pain control on perceptions of illness in surgical patients.

OBJECTIVES Adequacy of pain management in surgical patients is a major contributor to overall treatment outcomes and positive illness perceptions. However, it may be subjectively predetermined by a patients beliefs about pain control. This study assesses the relationships between beliefs about pain control and perceptions of illness in thoracic surgical patients. MATERIALS AND METHOD A total of 135 patients (72 women and 63 men; mean age 58.4±14.25y) were enrolled in the questionnaire study based on the Beliefs about Pain Control Questionnaire (BPCQ) by S. Skevington and the Multidimensional Essence of Disease and Illness Scale (MEDIS) by J. Sak. Analyses were conducted with use of the k-means clustering technique and one-way ANOVA. RESULTS Applied classification revealed 3 different clusters of patients with regard to their beliefs about pain control: 1) weak, undifferentiated pain control; 2) intensified influence of chance pain control; 3) strong undifferentiated pain control. Significant differences in illness perceptions between clusters were disclosed in 3 MEDIS dimensions: self-realization constraints (F=4.70; p=0.01; 1 vs. 3), mental dysfunction (F=3.44, p=0.04; 1 vs. 3) and physical dysfunction (F=3.10, p=0.05; 1 vs 2). Patients in cluster 3 demonstrated a greater feeling of self-realization constraints and mental dysfunction than in cluster 1, whereas patients in cluster 2 perceived physical dysfunction as a greater distress than those in cluster 1. CONCLUSIONS Beliefs about pain control significantly influence illness perceptions, and thus may affect the results of treatment in surgical patients. Psychological modelling of beliefs about pain control may offer a valuable way to improve overall clinical outcomes.

The history of scientific concepts of vision in relation to Ludwik Fleck's thought-styles.

The aim of the article is to assess the usefulness of Ludwik Fleck’s theory of thought‐styles for the history of ophthalmology. On the basis of Fleck’s ideas, the authors attempt to analyse the development of concepts of vision. They enumerate three styles in the history of ophthalmology: humoral, iatromechanical and micro‐tissue. In conclusion, they state that the history of evolution of the concept of vision should be considered not only from the perspective of achievements of individual scientists but also with the addition of the social ‘mood’ that prevailed in a given historical period.