Jalaluddin Ashraful Haq
Ibrahim Medical College
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Featured researches published by Jalaluddin Ashraful Haq.
BMC Research Notes | 2013
Shahanara Begum; Abdus Salam; Kh Faisal Alam; Nurjahan Begum; Pervez Hassan; Jalaluddin Ashraful Haq
BackgroundExtended spectrum ß-lactamases (ESBLs) represent a major group of lactamases responsible for resistance, mostly produced by gram-negative bacteria, to newer generations of ß-lactam drugs currently being identified in large numbers worldwide. The present study was undertaken to see the frequency of ESBL producing Pseudomonas spp. isolated from six hundred clinical specimens (wound, pus, aural, urine, sputum, throat and other swabs) collected over a period of three years from two tertiary care hospitals in Bangladesh.FindingsAerobic bacterial culture was performed on aseptically collected swabs and only growth of Pseudomonas was considered for further species identification and ESBL production along with serotyping of Pseudomonas aeruginosa. Antimicrobial susceptibility testing was carried out using the Kirby-Bauer agar diffusion method and ESBL production was detected on Mueller Hinton agar by double-disk synergy technique using Amoxicillin-Clavulanic acid with Ceftazidime, Cefotaxime, Ceftriaxone and Aztreonam. Culture yielded 120 Pseudomonas spp. and 82 of them were biochemically characterized for species. Pseudomonas aeruginosa was found to be the predominant (90.2%) species. Of 82 isolates tested for ESBL, 31 (37.8%) were ESBL positive with 29 (93.5%) as Pseudomonas aeruginosa, the remaining 2 (6.5%) were Stenotrophomonas maltophilia and Ralstonia pickettii. Antibiogram revealed Imipenem as the most effective drug (93.3%) among all antimicrobials used against Pseudomonas spp. followed by Aminoglycosides (63.7%).ConclusionESBL producing Pseudomonas spp. was found to be a frequent isolate from two tertiary care hospitals in Bangladesh, showing limited susceptibility to antimicrobials and decreased susceptibility to Imipenem in particular, which is a matter of great concern.
PLOS Neglected Tropical Diseases | 2016
Md. Shariful Alam Jilani; Jamshedul Alam Mohammad Robayet; Md. Mohiuddin; Md. Rokib Hasan; Chowdhury Rafiqul Ahsan; Jalaluddin Ashraful Haq
Background Melioidosis, caused by Burkholderia pseudomallei, is an endemic disease in Bangladesh. No systematic study has yet been done to detect the environmental source of the organism and its true extent in Bangladesh. The present study attempted to isolate B. pseudomallei in soil samples and to determine its seroprevalence in several districts in Bangladesh. Methodology and Results Soil samples were collected from rural areas of four districts of Bangladesh from where culture confirmed melioidosis cases were detected earlier. Multiple soil samples, collected from 5–7 sampling points of 3–5 sites of each district, were cultured in Ashdown selective media. Suspected colonies of B. pseudomallei were identified by biochemical and serological test, and by polymerase chain reaction (PCR) using 16s rRNA specific primers. Blood samples were collected from 940 healthy individuals of four districts to determine anti- B. pseudomallei IgG antibody levels by indirect enzyme linked immunosorbent assay (ELISA) using sonicated crude antigen. Out of 179 soil samples, B. pseudomallei was isolated from two samples of Gazipur district which is located 58 km north of capital Dhaka city. Both the isolates were phenotypically identical, arabinose negative and showed specific 550bp band in PCR. Out of 940 blood samples, anti- B. pseudomallei IgG antibody, higher than the cut-off value (>0.8), was detected in 21.5% individuals. Seropositivity rate was 22.6%-30.8% in three districts from where melioidosis cases were detected earlier, compared to 9.8% in a district where no melioidosis case was either detected or reported (p<0.01). Seropositivity increased with the advancement of age from 5.3% to 30.4% among individuals aged 1–10 years and > 50 years respectively. The seropositivity rates were 26.0% and 20.6% in male and female respectively, while it was 20–27% among different occupational groups. No significant association was observed with gender (χ2 = 3.441, p = 0.064) or any occupational group (χ2 = 3.835, p = 0.280). Conclusion This is the first study demonstrating the presence of B. pseudomallei in the environmental (soil) samples of Bangladesh. It also suggested that a large proportion of people, residing in these districts, were exposed to the organism.
BMC Research Notes | 2017
Subarna Dutta; Sabah Haq; Mohammad Rokibul Hasan; Jalaluddin Ashraful Haq
Archive | 2007
Shahanara Begum; Iftikhar Ahmed; Faisal Alam; Parvez Hassan; Nurul Absar; Jalaluddin Ashraful Haq
International Journal of Antimicrobial Agents | 2005
Jalaluddin Ashraful Haq; Mominur Rahman; S.M. Zahurul Haque Asna; M. M. Iqbal Hossain; Ishtaq Ahmed; Tariq A. Haq; Muhammad G Morshed
International Journal of Antimicrobial Agents | 2005
Jalaluddin Ashraful Haq; M Mushfequr Rahman; S.M. Zahurul Haque Asna; M. Akram Hossain; Iftekhar Ahmed; Tahniyah Haq; M.A.H. Golam Morshed
IMC Journal of Medical Science | 2017
Salma Khatun; Fahmida Rahman; Khandaker Shadia; Indrajit Kumar Dutta; Mohammad Nazmul Hoq; Farjana Akter; Jalaluddin Ashraful Haq
Bangladesh Journal of Medical Microbiology | 2017
Shahana Khanam; Mohammad Jobayer; S M Shamsuzzaman M Shamsuzzaman; Jalaluddin Ashraful Haq; Motlabur Rahman; Kazi Zulfiquer Mamun
Asian Pacific Journal of Tropical Medicine | 2017
Mahbuba Khatun; Sm Sabbir Alam; Abed Hussain Khan; M. Anwar Hossain; Jalaluddin Ashraful Haq; Md. Shariful Alam Jilani; Mohammad Tariqur Rahman; Muhammad Manjurul Karim
Bangladesh Critical Care Journal | 2016
Kaniz Fatema; Asm Areef Ahsan; Lovely Barai; Fatema Ahmed; Jalaluddin Ashraful Haq; Mohammad Omar Faruq