James E. P. Toman

The anticonvulsant properties of tridione: Laboratory and clinical investigations

T RIDIONE, 3,5,5-trimethyloxazolidine2, 4-dione, has recently been made available to physicians as a specific symptomatic therapy for petit ma1 epilepsy, and has been accepted by the Council on Pharmacy and Chemistry of the American Medical Association for inclusion in New and Nonofficial Remedies. The drug was synthesized by Spielman31 and initially studied and reported as an analgesic agent. 26,28 Its pharmacological and anticonvulsant properties were described by Richards and Everett8r26,27,28 and by LIS.~~~~~,-

Anticonvulsant Properties of 5,5-Phenyl Thienyl Hydantoin in Comparison with Dilantin and Mesantion.∗†‡

Summary A new anticonvulsant, 5,5-phenyl thienyl hydantoin, proposed for the treatment of epilepsy, has been compared with Dilantin and Mesantoin and Mesantoin by 4 different assay methods in rats and examined for its ability to modify the electroshock seizure pattern in man. The thienyl congener more closely resembles Dilantin than Mesantoin in its spectrum of antiepileptic actions.