James F. Hammarsten

Antitrypsin Deficiency in Pulmonary Disease: The Significance of Intermediate Levels

Abstract Deficiency of serum alpha1antitrypsin is inherited as an autosomal recessive trait, with the homozygous state manifested by severe deficiency and the heterozygous state by intermediate lev...

Precipitation of Congestive Heart Failure: Social and Emotional Factors

Abstract Because of discrepancies in the literature and common lack of knowledge about the role of emotions in the precipitation of congestive heart failure, a group of 105 patients with congestive...

Symptomatic Magnesium Deficiency in Man

IT is well known that magnesium deficiency occurs in man, but it is not generally agreed that it may produce symptoms.1 For this reason it is considered worth while to present the study of a well d...

Renal tubular secretion of magnesium in dogs.

Summary Excretion of magnesium has been studied in dogs utilizing the “stop-flow” technic and Mg28. The evidence indicates that magnesium is secreted by the distal tubule.

Differences between the normal serum protein patterns of American Indian, Negro and Caucasian subjects.

Summary Serum protein analyses of 3 ethnic groups (American Indian, Negro and Caucasian) revealed the following differences: 1. Indian and Negro subjects have a lower percentage of albumin and a higher percentage of beta and gamma globulins than do Caucasians. 2. Indian subjects have a higher percentage of alpha 1 globulin and a lower percentage of alpha 2 globulin than do Caucasians and Negroes.

Experimental granuloma formation with pine pollen

Abstract A total of 327 rats were sacrificed 2, 3, and 4 weeks and 6, 9, and 12 months after injection of whole pine pollen or pine pollen fractions. Sixty-three per cent of the 170 rats injected with whole pollen or the insoluble portions of the cell wall fraction showed granulomatous lesions in spleen, liver, and lungs. These resemble tubercles and are composed of epithelioid cells, Langhans type giant cells and a rim of lymphocytes. Acid-fast staining pine pollen fragments were found phagocytized within these giant cells. Chemical determinations of pine pollen so far have shown the presence of proteins, carbohydrates and nucleic acids in the soluble fraction. The insoluble fraction, which consists mostly of cell walls, contains loosely bound lipids and the material causing the pollen to stain acid-fast. With histochemical stains, localization and nature of the chemical substances in the giant cells and tubercles was studied. Histochemical staining of pine pollen before injection and of tubercles 4 weeks after injection of pollen showed the presence of acid-fast staining material, phospholipids, and PAS positive material indicating the presence of lipids and polysaccharides.

In vitro Inhibition of Growth of M. tuberculosis by Certain 11-Oxygenated Steroids

Summary Hydrocortisone and corticosterone in a concentration of 100 μg/ml markedly inhibit growth of isoniazid sensitive and resistant strains of tubercle bacilli grown in a simple synthetic culture medium. Ten and 20 μg/ml produce slight slowing of growth in some strains.

HODGKIN'S SARCOMA SIMULATING VENTRICULAR ANEURYSM

Excerpt According to a number of reported autopsy series, infiltration of the myocardium by nests of malignant cells is not rare in Hodgkins sarcoma, nor are small nodules on the pericardium.1Howe...