James G. Phillips

Potential determinants of heavier internet usage

Despite its uses, the Internet is liable to be abused. “Internet Addiction” is a newly proposed construct, derived form DSM-IV criteria for substance abuse. As a very recent phenomenon, excess internet use probably arises through pre-existing mechanisms. The addictive element may be the search for stimulation through interactive services, or the Internet may serve the purpose of an escape from real-life difficulties. We therefore considered the extent to which sensation seeking or poor self-esteem predicts heavier Internet use. Fifty participants, recruited through the Internet or the Internet Addiction Support Group, completed an Internet Related Problem Scale, the MMPI-2 Addiction Potential Scale, the Coopersmith Self-Esteem Inventory and the Sensation Seeking Scale. The Internet Related Problem Scale showed a moderate level of internal consistency and demonstrated construct validity, predicting hours of Internet use and having a relationship with the Addiction Potential Scale. While poorer self-esteem predicted greater scores on the Internet Related Problem Scale, impulsivity did not. Researchers need to re-assess previous conceptualizations of the typical “computer addict” as a highly educated, male introvert with a constant need for intellectual stimulation (Shotton, 1991).

Frontostriatal deficits in unipolar major depression

Recent accounts of major depression have tended to focus on dysfunction of frontothalamic-striatal reentrant circuits as a possible source of the disorder. Evidence of frontostriatal involvement in unipolar major depression from lesion and neuropsychological studies, and functional and structural imaging studies is examined. The high incidence of depressive symptomatology following left frontal and basal ganglia lesions implicate these as possible sites of dysfunction. Neuropsychological evidence indicates similar deficits in patients with major depression, perhaps with dorsolateral prefrontal deficits most prominent. Structural imaging studies report frontal and basal ganglia (BG) abnormalities particularly in cases of late-age onset depression. Resting state functional imaging studies show deficits in dorsolateral, anterior cingulate (medial frontal), and BG structures. Activation imaging studies show less consistent evidence of dorsolateral deficit, while anterior cingulate deficit is more consistently demonstrated. Variability in findings across studies may reflect differences between subtypes of depression and differences in methodology. Possible involvement of the BG in the psychomotor retardation of depression is examined. It is concluded that, while there is evidence of frontostriatal deficit in major depression, the exact nature of such deficits is uncertain. Issues such as component vs. system dysfunction need to be addressed.

Automatic behaviour : Efficient not mindless

Automaticity is a core construct underpinning theoretical accounts of human performance and cognition. In spite of this, its current conceptualisation is plagued by circularity - automaticity is typically defined in terms of the very behaviour it seeks to explain - and a lack of internal consistency-defining features of automaticity do not reliably co-occur. Furthermore, invoking automaticity tends to be post hoc as it is used to explain violations of dominant theories of attention. Prevailing models of automaticity explain automatic processing as merely faster processing than controlled processing. We present an alternative conceptualisation of automaticity as efficient, elegant and economical but not fast. This is supported by functional imaging studies, which reveal a pattern of reduced global activation as well as a shift in activation from cortical to subcortical areas once automaticity has been achieved. Were automaticity to be faster processing, functional imaging would indicate greater activation when an automatic task is performed. We propose possible circuitry of automaticity incorporating the direct pathways of the basal ganglia.

Movement-related potentials associated with movement preparation and motor imagery

Movement-related potentials (MRPs), reflecting cortical activity associated with voluntary movement, typically show a slowly increasing negative potential beginning between 1 and 2 s prior to movement, which most likely reflects motor preparatory processes. Studies of regional cerebral blood flow implicate the supplementary motor area in such preparatory processes; however, the contribution of the supplementary motor area to premovement activity observed in MRPs is debated. It is possible to examine MRPs relating to movement prepa4-ration alone, in the absence of movement execution, by recording MRPs associated with imagined movements. In this study, MRPs were recorded from 11 healthy control subjects while performing a sequential button-pressing task in response to external cues, and while imagining performance of the same task in response to the same cues. The early component of MRPs was found not to differ in amplitude, onset time, or topography when performing compared with imagining movement, indicating that both movement execution and motor imagery involve similar pre-movement preparatory processes generated in the same cortical area — most likely the supplementary motor area. It is therefore concluded that the early component of the MRP reflects activity arising pre-dominantly from the supplementary motor area and is associated with pre-movement motor preparatory processes which occur relatively independently of actual movement execution.

Characteristics of cursor trajectories controlled by the computer mouse

An analysis of computer screen cursor trajectories can provide insights into the factors limiting efficient cursor positioning and can assist in the design of humancomputer interfaces. Cursor locations as controlled by a Microsoft computer mouse with standard settings were therefore sampled at 5ms intervals and kinematic analyses addressed the proportions of time spent in the initiation, accelerative and terminal guidance phases of cursor positioning. Twelve participants used a computer mouse to move a cursor over different distances (7.5cm, 15cm) from a home location in the lower centre of the screen to targets of different diameters (8mm, 16mm), situated to the left, middle or right of the computer screen. Cursor trajectories were irregular, and participants regularly overshot their targets, spending 70% of movement duration in terminal guidance. Participants appeared to use the initial part of their movement to establish mappings between controller and display. Interventions should seek to reduce the terminal guidance phase of cursor positioning.

Impairments of Movement Execution in Unilateral Neglect - a Kinematic Analysis of Directional Bradykinesia

A kinematic analysis was performed on goal-directed movements made by 14 patients with right hemisphere damage and left unilateral neglect (seven mild, seven severe), and 14 healthy controls. Leftward and rightward pen strokes of varying extents were made to targets of varying size on a centrally located digitising tablet. While mild unilateral neglect patients performed like controls, patients with severe unilateral neglect were slower to initiate leftward than rightward strokes and were slow and inefficient in movement execution. Leftward strokes made by severe unilateral neglect patients were characterised by prolonged movement time, lower peak velocity and departed from optimal bell-shaped velocity profiles. Their leftward strokes also showed prolonged accelerative phases, implying difficulties in force production, while the high proportion of their total movement time spent in decelerating with rightward strokes suggested an abnormal emphasis on terminal visual guidance. Leftward strokes made by these patients also contained more submovements than rightward strokes, suggesting poor force control. An impaired internal representation of the location of left-sided targets and desired movement trajectories in severe unilateral neglect causes breakdown in the temporal control of goal-directed movements.

To see or not to see: The effects of visible and invisible cues on line bisection judgements in unilateral neglect

Patients with left unilateral neglect and matched controls were tested in two experiments to examine the effects of lateralized cues on line bisection judgements. Unlike previous studies in which letter or number cues were placed beyond the endpoint(s) of each line, we adopted a procedure which maintained the perceptual point of balance in the horizontal axis of each line. We also related the cueing task more closely to the act of bisection by requiring subjects to place a small mark in direct alignment with the endpoint(s) of each line. In the first experiment, it was found that, for controls, the presence or absence of visible lateralized cues did not differentially affect the magnitude of bisection errors. However, the magnitude of bisection errors made by neglect patients was significantly reduced (and reversed) in the presence of a visible left-sided cue, but remained well to the right of the midpoint in the absence of such cues. In a second experiment, subjects engaged in an otherwise identical cueing procedure, except that no visible marks appeared on the stimulus lines. Neither subject group was affected by the presence or absence of right-sided cues. However, the presence of left-sided cues again reduced the magnitude of bisection errors in neglect patients, but not in controls. These results indicate that the extent of the attentional bias exhibited by neglect patients can be ameliorated even in the absence of lateralized visible cues.

Inaccuracy and instability of sequential movements in Parkinson's disease.

Animal studies suggest that the basal ganglia (BG) provide internal cues to trigger submovements in a movement sequence, with Parkinsons disease (PD) involving a deficiency in this cueing mechanism. However, it is not clear why defective internal cues can produce slow movements, or the extent to which slow movements are indeed the basic movement abnormality or are perhaps a compensatory mechanism for some other primary deficit. In this study we examined a number of the kinematic indices of matched fast movements between PD patients and age-matched controls, performed with and without reductions in visual cues for guidance, in order to delineate the relationship between the internal cue and the kinematic characteristics of these movements. Fourteen patients with PD, and their matched controls, used an electronic pen, which sampled pen-tip position at 200 Hz, and performed a se quence of drawing movements to nine targets upon a WACOM SD 420 graphics tablet. Subjects were trained to perform the movement sequence at a fast speed and were then required to perform the same movement at the same speed with reduced visual cues. Kinematic analysis indicated that, when visual cues were reduced, movements of PD patients became spatially and temporally unstable as they were progressively performed down the sequence. The instability was associated with an abnormal force profile, increase in peak movement velocity and target overshoot, which became additive as the submovements progressed. We suggest that defective cue production is the basic deficit in parkinsonian hypokinesia. The defective cue leads to problems synchronising preparatory activity, which then results in abnormalities in movement forces which are characterised by unpredictable and inaccurate movement endpoints. When movements are strung together in a sequence the inaccuracy is additive leading to motor in stability.

Contingent and non-contingent auditory cueing in Parkinson's disease

Parkinsons disease (PD) patients and their normal controls performed two experiments involving a sequential movement task, depressing a series of buttons at choice points along a response board. Visual or auditory cues were presented prior to each move according to various contingencies. PD, a disorder characterised by degeneration of the basal ganglia (BG), typically manifests with poor execution of motor sequences. We found that external cueing facilitated motor sequencing in PD patients. In particular, auditory cues which occurred late in the movement cycle maximally facilitated switching between subcomponents of a sequence. Based on physiological findings reported in the primate literature [Brotchie et al., Brain 114, 1685-1702, 1978; Schultz and Romo, Exp. Brain Res. 1, 363-384, 1992], it is suggested that external cues enhance performance by replacing defective, internally generated cues (discharges) of the BG. This has implications for the use of physical training strategies in the treatment of PD.

Parkinsonian patients without dementia or depression do not suffer from bradyphrenia as indexed by performance in mental rotation tasks with and without advance information.

A predominant symptom of Parkinsons disease is akinesia and bradykinesia, slowing in the initiation and execution of voluntary movement. There has long been speculation as to whether cognitive processes undergo similar processes, but findings may be confounded by the frequent co-occurrence of dementia and/or depression. Mental rotation provides an internal or cognitive analogue of real movement, and enables us to determine the speed of such mental processes independent of any concurrent motor slowing in response initiation and execution. Medicated patients with Parkinsons disease who were free of dementia and depression were found to be able to mentally rotate alphanumeric or figural stimuli, with and without advance information as to the view (front or back) of a stick figure shortly to be shown, as rapidly as normal healthy controls. We conclude that cognitive processes involved in mental rotation are not necessarily slowed in Parkinsons disease.