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Featured researches published by James H. Austin.


Journal of Neurochemistry | 1963

A CONTROLLED STUDY OF ENZYMIC ACTIVITIES IN THREE HUMAN DISORDERS OF GLYCOLIPID METABOLISM.

James H. Austin; A.S. Balasubramanian; T. N. Pattabiraman; S. Saraswathi; D. K. Basu; B. K. Bachhawat

A CONTROLLED STUDY OF ENZYMIC ACTIVlTIES IN THREE HUMAN DISORDERS OF GLYCOLIPID METABOLISM” JAMES H. AUSTIN Division of Neurology, University of Oregon Medical School, Portland, Oregon, U.S.A. A . s. BALASUBRAMANIAN~, T. N. PATTABIRAMAN


Experimental Biology and Medicine | 1959

Metachromatic Sulfatides in Cerebral White Matter and Kidney.

James H. Austin

, s. SARASWATHI, D. K. BASUS and B. K. BACHHAWAT Neurochemistry Laboratory, Department of Neurology and Neurosurgery, Christian Medical College & Hospital, Vellore, S. India


Mikrochimica Acta | 1960

A new spectrophotometric method for the micro determination of sulfuric acid esters in sulfatide fractions

Frank Witmer; James H. Austin

Summary 1) Metachromatic sulfuric acid esters (SAE) were measured in sulfatide fractions extracted from normal and abnormal white matter and kidney. 2) Slightly lower than average SAE values for white matter were found in early childhood, in old age, and in diseases interfering with myelin metabolism. 3) The average SAE value in normal mature white matter was 58 mg/g. This was 10 times the value for normal kidney and corresponds with the much greater lipid metachromasia in white matter histologically. 4) Statistically significant elevations in sulfatide values were found in white matter and kidney in one disease (metachromatic leucoencephalopathy). 5) This accumulation may be related to an error in sulfatide metabolism, and appears, descriptively, to constitute a “sulfatide lipidosis.”


Experimental Biology and Medicine | 1961

Significance of plasma glycolipid levels in normals and in 3 disorders of brain glycolipids.

James H. Austin; Winston E. Maxwell

SummaryA new micro method has been developed for measuring sulfatide fractions. Sulfuric acid ester absorption is measured at 8.02 μm (μ) by infrared spectrophotometry, compared with that of a standard sulfatide, and corrected for phosphorus. General problems in measuring sulfatides are noted; procedural details, control studies, advantages, and limitations of the present method are discussed.ZusammenfassungEine neue Mikromethode für die Bestimmung von Sulfatidfraktionen wird beschrieben. Die Absorption der Schwefelsäureester wird im Infrarot bei 8,02 μm gemessen, mit jener eines Sulfatidstandards verglichen und für Phosphor korrigiert. Allgemeine, mit der Bestimmung von Sulfatiden verbundene Probleme werden erwähnt; technische Einzelheiten, Kontroll-untersuchungen, Vorteile und Grenzen der beschriebenen Methode werden besprochen.RésuméMise au point dune nouvelle microméthode pour la détermination de fractions de sulfatides. Labsorption de lester sulfurique est mesurée à 8,02 μm (μ) par spectrophotométrie infra-rouge et comparée avec celle dun sulfate standard puis corrigée du fait de la présence du phosphore. Les auteurs rappellent les problèmes généraux rencontrés dans la détermination des sulfatides. Les détails opératoires, les études de contrôle, les avantages et les limitations de la présente méthode sont dautre part discutés.


JAMA Neurology | 1973

Studies in Metachromatic Leukodystrophy: XII. Multiple Sulfatase Deficiency

James H. Austin

Summary 1. Plasma glycolipids and other plasma lipids were studied in 2 diseases affecting the myelin glycolipids, in gargoylism, and in controls of appropriate age. 2. Plasma glycolipid levels in this series of normal children ranged from 4.9-6.5 mg%. Those in 2 metachromatic children ranged from 6.0-6.3 mg%. In the globoid child. plasma glycolipids ranged from 4.3-5.1 mg%. 3. Data obtained with these methods would not appear to establish a disorder of total plasma glycolipids per se as the primary source for systemic deposits in the patients studied. 4) The significance of the plasma glycolipid level is considered, and the need for individualization in further studies is stressed. It is a pleasure to acknowledge the assistance of the Dept. of Pediatrics and of Mrs. Margaret Bischel in obtaining plasma samples, and that of Mrs. Jean Scott and Mr. David Gaudin in cholesterol and phosphorous determinations.


Biochimica et Biophysica Acta | 1963

A modified benzidine method for the chromatographic detection of sphingolipids and acid polysaccharides

Margaret D. Bischel; James H. Austin


JAMA Neurology | 1968

Metachromatic Leukodystrophy (MLD): VIII. MLD in Adults; Diagnosis and Pathogenesis

James H. Austin; Donald Armstrong; Sally Fouch; Curtin Mitchell; David Stumpf; Leslie Shearer; O. Briner


JAMA Neurology | 1974

Studies in Myoclonus Epilepsy (Lafora Body Form): IV. Skeletal Muscle Abnormalities

Hans E. Neville; Michael H. Brooke; James H. Austin


JAMA Neurology | 1971

Familial Hypoplasia of Both Internal Carotid Arteries

James H. Austin; John Stears


Blood | 1961

A Histochemical Method for Sulfatase Activity in Hemic Cells and Organ Imprints

James H. Austin; Margaret D. Bischel

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Hans E. Neville

University of Colorado Denver

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Michael H. Brooke

Washington University in St. Louis

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