James H. Simpson | Researchain

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Featured researches published by James H. Simpson.

Tetrahedron Letters | 1998

A chemoselective, acid mediated conversion of amide acetal to oxazole: The key step in the synthesis of cardiovascular drug, ifetroban sodium

Shankar Swaminathan; Ambarish K. Singh; Wen-Sen Li; John J. Venit; Kenneth J. Natalie; James H. Simpson; Raymond E. Weaver; Lee J. Silverberg

Abstract The cyclization of acetal amide was carried out with trimethylsilyl trifluoromethanesulfonate, followed by elimination using sodium methoxide to give 2,5-disubstituted oxazole, thus completing a new route to the cardivascular drug ifetroban sodium.

Organic Process Research & Development | 1997

Removal of Palladium from Organic Reaction Mixtures by Trimercaptotriazine

Victor W. Rosso; David A. Lust; Peter J. Bernot; John Anthony Grosso; Sandeep P. Modi; Andrew Rusowicz; Thomas C. Sedergran; James H. Simpson; Sushil K. Srivastava; Michael J. Humora, ,§ and; Neal G. Anderson

Journal of Organic Chemistry | 1996

SULFONATION WITH INVERSION BY MITSUNOBU REACTION : AN IMPROVEMENT ON THE ORIGINAL CONDITIONS

Neal G. Anderson; David A. Lust; Kay A. Colapret; James H. Simpson; Mary F. Malley; Jack Z. Gougoutas

Tetrahedron-asymmetry | 2003

A pilot-scale synthesis of (1R)-trans-2-(2,3-dihydro-4-benzofuranyl)cyclopropanecarboxylic acid: a practical application of asymmetric cyclopropanation using a styrene as a limiting reagent

James H. Simpson; Jollie D. Godfrey; Rita Fox; Atul S. Kotnis; David Kacsur; Jason Hamm; Michael Totelben; Victor W. Rosso; Richard H. Mueller; Edward J. Delaney; Rajendra P. Deshpande

Organic Process Research & Development | 1997

Process Development of 5-Fluoro-3-[3-[4-(5-methoxy-4-pyrimidinyl)-1- piperazinyl]propyl]-1H-indole Dihydrochloride

Neal G. Anderson; Thomas D. Ary; James L. Berg; Peter J. Bernot; Yeung Y. Chan; Chien-Kuang Chen; Merrill L. Davies; John D. Dimarco; Ronald D. Dennis; Rajan P. Deshpande; Hoang D. Do; Roberto Droghini; William Early; Jack Z. Gougoutas; John Anthony Grosso; John C. Harris; Oscar W. Haas; Paul A. Jass; Daniel H. Kim; Gus Kodersha; Atul S. Kotnis; Jean Lajeunesse; David A. Lust; Gary D. Madding; Sandeep P. Modi; Jerome L. Moniot; Andrew Nguyen; Venkatapuram Palaniswamy; Douglas W. Phillipson; James H. Simpson

Organic Process Research & Development | 2002

Development of a practical, safe, and high-yielding process for the preparation of enantiomerically pure trans-cyclopropane carboxylic acid

Ambarish K. Singh; Meena N. Rao; James H. Simpson; Wen-Sen Li; John E. Thornton; and Daniel E. Kuehner; David Kacsur

Archive | 2001

METHOD FOR THE PREPARATION OF FUSED HETEROCYCLIC SUCCINIMIDE COMPOUNDS AND ANALOGS THEREOF

Mark E. Salvati; Toomas Mitt; Ramesh N. Patel; Ronald L. Hanson; David B. Brzozowski; Animesh Goswami; Linda Nga Hoong Chu; Wen-Sen Li; James H. Simpson; Michael J. Totleben; Weixuan He

Archive | 1999

PREPARATION OF [4S-(4α,7α,10Aβ)]-4-AMINO-OCTAHYDRO-5-OXO-7H-PYRIDO[2,1-B][1,3]THIAZEPINE-7-CARBOXYLIC ACID, METHYL ESTER AND SALTS THEREOF VIA NOVEL DISULFIDES

Jerome L. Moniot; Sushil K. Srivastava; William J. Winter; John J. Venit; Shankar Swaminathan; Keith Ramig; Paul A. Jass; Mark D. Schwinden; John L. Dillon; Saibaba Racha; James H. Simpson; Chien-Kuang Chen; Shawn K. Pack

Archive | 1998

Deprotection and recrystallization processes

David R. Kronenthal; Theodor Denzel; Bang-Chi Chen; James H. Simpson; Rajendra P. Deshpande

Archive | 2014

Methods for the preparation of HIV attachment inhibitor piperazine prodrug compound

Martin D. Eastgate; Michael Bultman; Ke Chen; Dayne Fanfair; Richard J. Fox; Thomas E. La Cruz; Boguslaw Mudryk; Christina Risatti; James H. Simpson; Maxime Soumeillant; Jonathan C. Tripp; Yi Xiao

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