James L. Stanton

The use of thioesters in solid phase organic synthesis

Abstract Mercaptan-resin linkers are used for the synthesis of C-terminal thioesters which are then cleaved with alcohols, amines and organometallic reagents to generate esters, amides, ketones, aldehydes and alcohols as the final products of solid phase synthesis.

Synthesis and biological activity of phenoxyphenyl oxamic acid derivatives related to L-thyronine.

The synthesis of substituted phenoxyphenyl oxamic acid derivatives related to L-thyronine (L-T3) is described. The in vitro and in vivo cholesterol lowering and cardiovascular effects of these compounds are presented and discussed.

The effect of heteroatom substitution on a series of phosphonate inhibitors of neutral endopeptidase 24.11

Abstract A series of phosphonic acids, 7a–d, with heteroatom and carbon variations in the template backbone were prepared and tested for inhibition of neutral endopeptidase 24.11. The structure-activity relationship of these derivatives is presented and discussed.