James M. Ruegsegger

Poliovirus antibody three years after oral trivalent vaccine (Sabin strains)

A sample group of children who had no poliovirus antibody before vaccination was tested three years after vaccination. For poliovirus Types II and III, 100 per cent and 94.5 per cent of the children, respectively, retained antibody titers of at least 1:16. Only for Type I was the antibody-positive rate appreciably lower than at two years after vaccination, 81.3 per cent compared with 94.5 per cent; eight more children had a titer below 1:16. However, all but two children had a Type I titer of at least 1:8.

Immunizing properties of live attenuated measles virus

Summary Early clinical trials indicate that it is possible to immunize children with live attenuated measles virus. The susceptible subjects develop either no symptoms at all or a modified measles with fever, leukopenia, and a faint eruption. Koplik spots are uncommon. These children have no catarrhal symptoms and do not appear toxic. All of the susceptible children developed a significant titer of neutralizing antibodies. No complications occurred in any of our cases. The urgent need of a measles vaccine is stressed, and there are indications that measles immunization as a routine procedure may not be too distant.