James O. Armitage

Cytogenetic Abnormalities in B-Immunoblastic Lymphoma

We have considered the cytogenetic abnormalities present in 27 unpublished cases of B-immunoblastic lymphoma. Among these 27 patients, the chromosome changes were heterogeneous and complex. The chromosomes most commonly gained were 3 (44% of cases), 18 (44%), 6 (30%) and 11 (30%). The most common structural abnormalities involved band 14q32 (26%), band 18q21 (15%) and bands 6q16-21 (19%). Study of these 27 immunoblastic lymphomas did not allow us to tentatively identify a common primary cytogenetic abnormality unique to B-immunoblastic lymphoma, however, a translocation at 14q32 may be the primary cytogenetic lesion in some of the cases. Rather, we have added to the number of abnormalities reported in immunoblastic lymphoma and in non-Hodgkins lymphoma in general.

Textbook of Medical Oncology, Fourth Edition

Role and future of medical oncology molecular biology of cancer principles of systemic therapy principles of clinical trials breast cancer gynaecological cancer head and neck cancer lung cancer gastrointestinal cancer urologic cancer sarcoma childhood cancer leukaemias non-Hodgkins lymphoma Hodgkins disease myeloma brain tumours melanoma tumours of unknown origin support care management of medical emergencies evaluation of quality of life palliative and home care.