James O. Bond

Central nervous system mumps A review of 64 cases

SUMMARYWe have reviewed 64 cases of documented central nervous system mumps which were referred to the Epidemiology Research Center for laboratory diagnosis between 1963 and 1968. Fifty-five were classified as mumps viral meningitis and 9 as meningoencephalitis. The average time interval between onset of parotitis and the development of CNS symptoms was 2.7 days, and mumps viral complement-fixing antibodies reached a geometric mean peak level of 1:96 between two and three weeks after onset of mumps illness. Follow-up neurological, psychometric, and audiometric performance tests on 19 patients revealed no significant differences between the patients and a group of matched controls, although one of those with meningoencephalitis had suggestive evidence of minimal brain damage.

California group arboviruses in Florida and report of a new strain, Keystone virus.

Dr. Bond is director, Dr. Lewis is chief virologist, and Mr. Taylor is chief entomologist, Encephalitis Research Center, Florida State Board of Health, Tampa. Dr. Hammon is professor of epidemiology, and Miss Sather is a research associate, department of epidemiology and microbiology, University of Pittsburgh Graduate School of Public Health, Pitts¬ burgh, Pa. Epidemiologic studies were directed in part by Dr. Emily H. Gates, biological studies by Dr. Wil¬ liam L. Jennings, entomological identification by Karen Meadows, serologic work by Florence Y. Lewis, and statistical analyses by Ingrid Baugh-