James P. Albarella
Miles Laboratories
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Publication
Featured researches published by James P. Albarella.
Journal of Immunological Methods | 1983
Michael A. Place; Robert J. Carrico; Frances M. Yeager; James P. Albarella; Robert C. Boguslaski
A competitive binding immunoassay was developed using an enzyme inhibitor for labeling the analyte. Thyroxine was labeled by covalent coupling of the alpha-amino group to the gamma-carboxyl of the glutamyl residue of methotrexate. This thyroxine-methotrexate conjugate was a potent inhibitor of dihydrofolate reductase. When antibody was bound to the thyroxine moiety, the inhibitor was inactivated. Thus, a competitive binding immunoassay for thyroxine was demonstrated based on colorimetric measurement of dihydrofolate reductase activity.
Journal of Chromatography A | 1985
Kin Fai Yip; James P. Albarella
Abstract High-performance liquid chromatography (HPLC) was used for the study of the chemical synthesis of the flavin adenine dinucleotide analyte conjugates. A preparative HPLC method was also developed for the purification of the conjugates directly from the reaction mixture with minimum sample pretreatment. The preparations of flavin N6-(N-6-aminohexyl)adenine dinucleotide and flavin adenine dinucleotide theophylline conjugate are given as examples to illustrate the importance of this method.
Archive | 1984
James P. Albarella; Leslie H Anderson
Archive | 1982
James P. Albarella; Robert J. Carrico; Thomas M. Li
Analytical Chemistry | 1981
David L. Morris; Paul B. Ellis; Robert J. Carrico; Frances M. Yeager; Hartmut Schroeder; James P. Albarella; Robert C. Boguslaski; William Edward Hornby; Denise. Rawson
Archive | 1982
James P. Albarella
Archive | 1984
James P. Albarella; Deriemer Leslie H. Anderson; Robert J. Carrico
Molecular and Cellular Probes | 1987
Clifford O. Yehle; William L. Patterson; Sophie J. Boguslawski; James P. Albarella; Kin Fai Yip; Robert J. Carrico
Archive | 1984
James P. Albarella; Deriemer Leslie H. Anderson; Robert J. Carrico
Archive | 1981
James P. Albarella; Robert J. Carrico; Thomas M. Li