James Pribish
Aventis Pharma
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Publication
Featured researches published by James Pribish.
Bioorganic & Medicinal Chemistry Letters | 2012
Guyan Liang; Suzanne Aldous; Gregory H. Merriman; Julian Levell; James Pribish; Jennifer Cairns; Xin Chen; Sébastien Maignan; Magali Mathieu; Joseph Tsay; Keith Sides; Sam Rebello; Brian Whitely; Isabelle Morize; Henry W. Pauls
A solid phase combinatorial library was designed based on X-ray structures and in-silico models to explore an inducible S4+ pocket, which is formed by a simple side-chain rotation of Tyr95. This inducible S4+ pocket is unique to β-tryptase and does not exist for other trypsin-like serine proteases of interest. Therefore, inhibitors utilizing this pocket have inherent advantages for being selective against other proteases in the same family. A member of this library was found to be a potent and selective β-tryptase inhibitor with a suitable pharmacokinetic profile for further clinical evaluation.
Archive | 2001
Peter Charles Astles; Paul Robert Eastwood; Olivier Houille; Julian Levell; Heinz W. Pauls; Mark Czekaj; Guyan Liang; Yong Gong; James Pribish; Kent Neuenschwander
Bioorganic & Medicinal Chemistry Letters | 2005
Corey R. Hopkins; Mark Czekaj; Steven S. Kaye; Zhongli Gao; James Pribish; Henry W. Pauls; Guyan Liang; Keith Sides; Dona Cramer; Jennifer Cairns; Yongyi Luo; Heng Keang Lim; Roy J. Vaz; Sam Rebello; Sebastian Maignan; Alain Dupuy; Magali Mathieu; Julian Levell
Bioorganic & Medicinal Chemistry | 2005
Julian Levell; Peter Charles Astles; Paul Robert Eastwood; Jennifer Cairns; Olivier Houille; Suzanne Aldous; Gregory H. Merriman; Brian Whiteley; James Pribish; Mark Czekaj; Guyan Liang; Sébastien Maignan; Jean-Pierre Guilloteau; Alain Dupuy; Jane Davidson; Trevor K.P. Harrison; Andrew David Morley; Simon Watson; Garry Fenton; Clive McCarthy; Joseph Romano; Rose Mappilakunnel Mathew; Darren Engers; Michael Gardyan; Keith Sides; Jennifer Kwong; Joseph Tsay; Sam Rebello; Liduo Shen; Jie Wang
Journal of Medicinal Chemistry | 1967
James Pribish; Cynthia A. Gates; Philip M. Weintraub
Archive | 2008
Suzanne Aldous; Michael W Fennie; John Z. Jiang; Stanly John; Lan Mu; Brian Pedgrift; James Pribish; Barbara Rauckman; Jeffrey S. Sabol; Grzegorz T Stoklosa; Sukanthini Thurairatnam; Christopher Loren Vandeusen
Bioorganic & Medicinal Chemistry Letters | 2004
Roy J. Vaz; Zhongli Gao; James Pribish; Xin Chen; Julian Levell; Larry Davis; Eva Albert; Maurice Brollo; Antonio Ugolini; Dona Cramer; Jennifer Cairns; Keith Sides; Feng Liu; Jennifer Kwong; Jiesheng Kang; Sam Rebello; Michael Elliot; Heng-Keang Lim; Vinolia Chellaraj; Robert W. Singleton; Yi Li
Archive | 1997
James Pribish; Cynthia A. Gates; Philipp M Weintraub
Archive | 2008
Brian Pedgrift; Suzanne Aldous; Michael W Fennie; John Z. Jiang; Stanly John; Lan Mu; James Pribish; Barbara Rauckman; Jeffrey S. Sabol; Grzegorz T Stoklosa; Sukanthini Thrurairatnam; Christopher Loren Vandeusen
Archive | 2008
Suzanne Aldous; Michael W Fennie; John Z. Jiang; Stanly John; Lan Mu; Brian Pedgrift; James Pribish; Barbara Rauckman; Jeffrey S. Sabol; Grzegorz T Stoklosa; Sukanthini Thurairatnam; Christopher Loren Vandeusen