James R. Cooper

Alterations of the blood–brain barrier in cerebral white matter lesions in the ageing brain

White matter lesions (WML) are associated with dementia and are common in brain ageing. In order to determine whether alteration of the blood-brain barrier (BBB) may contribute to the pathogenesis of WML we assessed albumin leakage and expression of the tight junction (TJ) proteins claudin-5 (Cln-5), zona occludin-1 (ZO-1) and occludin in cases derived from the Medical Research Council Cognitive Function and Ageing Study. Albumin extravasation was widespread in the ageing brain and enhanced in WML, suggesting dysfunction of the BBB may contribute to the pathogenesis of WML. This was not accompanied by significant changes in the endothelial expression of TJ proteins. However, ZO-1 and occludin were expressed by glial cells throughout the parenchyma of both control white matter and WML, suggesting these TJ proteins may have other functions in the brain.

The concept of transport capacity in geomorphology

The notion of sediment-transport capacity has been engrained in geomorphological and related literature for over 50 years, although its earliest roots date back explicitly to Gilbert in fluvial geomorphology in the 1870s and implicitly to eighteenth to nineteenth century developments in engineering. Despite cross fertilization between different process domains, there seem to have been independent inventions of the idea in aeolian geomorphology by Bagnold in the 1930s and in hillslope studies by Ellison in the 1940s. Here we review the invention and development of the idea of transport capacity in the fluvial, aeolian, coastal, hillslope, debris flow, and glacial process domains. As these various developments have occurred, different definitions have been used, which makes it both a difficult concept to test, and one that may lead to poor communications between those working in different domains of geomorphology. We argue that the original relation between the power of a flow and its ability to transport sediment can be challenged for three reasons. First, as sediment becomes entrained in a flow, the nature of the flow changes and so it is unreasonable to link the capacity of the water or wind only to the ability of the fluid to move sediment. Secondly, environmental sediment transport is complicated, and the range of processes involved in most movements means that simple relationships are unlikely to hold, not least because the movement of sediment often changes the substrate, which in turn affects the flow conditions. Thirdly, the inherently stochastic nature of sediment transport means that any capacity relationships do not scale either in time or in space. Consequently, new theories of sediment transport are needed to improve understanding and prediction and to guide measurement and management of all geomorphic systems.

Erosion and Accretion on a Mudflat: The Importance of Very Shallow‐Water Effects

Understanding erosion and accretion dynamics during an entire tidal cycle is important for assessing their impacts on the habitats of biological communities and the long-term morphological evolution of intertidal mudflats. However, previous studies often omitted erosion and accretion during very shallow-water stages (VSWS, water depths  0.2 m (i.e., probe submerged) are considered. These findings suggest that the magnitude of bed-level changes during VSWS should not be neglected when modeling morphodynamic processes. Our results are useful in understanding the mechanisms of micro-topography formation and destruction that often occur at VSWS, and also improve our understanding and modeling ability of coastal morphological changes.

Does the permeability of gravel river beds affect near-bed hydrodynamics?

The permeability of river beds is an important control on hyporheic flow and the movement of fine sediment and solutes into and out of the bed. However, relatively little is known about the effect of bed permeability on overlying near-bed flow dynamics, and thus on fluid advection at the sediment-water interface. This study provides the first quantification of this effect for water-worked gravel-beds. Laboratory experiments in a recirculating flume revealed that flows over permeable beds exhibit fundamental differences compared with flows over impermeable beds of the same topography. The turbulence over permeable beds is less intense, more organised and more efficient at momentum transfer because eddies are more coherent. Furthermore, turbulent kinetic energy is lower, meaning that less energy is extracted from the mean flow by this turbulence. Consequently, the double-averaged velocity is higher and the bulk flow resistance is lower over permeable beds, and there is a difference in how momentum is conveyed from the overlying flow to the bed surface. The main implications of these results are three-fold. First, local pressure gradients, and therefore rates of material transport, across the sediment-water interface are likely to differ between impermeable and permeable beds. Second, near-bed and hyporheic flows are unlikely to be adequately predicted by numerical models that represent the bed as an impermeable boundary. Third, more sophisticated flow resistance models are required for coarse-grained rivers that consider not only the bed surface but also the underlying permeable structure. Overall, our results suggest that the effects of bed permeability have critical implications for hyporheic exchange, fluvial sediment dynamics and benthic habitat availability.

Virtual velocity of sand transport in water

Using the 160-m-long flume at Tsukuba University we undertook an experiment to provide a first estimate of the virtual velocity of sand in the size range 0.5 – 2.0 mm. For the flow velocity used in our experiment this sediment-size range would conventionally be regarded as suspended sediment. The virtual velocity is found to be 37-41 % of the flow velocity. Paradoxically, virtual velocity decreases as particle size decreases. Such a lower virtual velocity of finer sediment is not inconceivable. First, trapping of the sediment appears to be a function of bed roughness, and there is a probable relationship between bed roughness and trapping efficiency for particles of different sizes. Secondly, finer particles are more likely to find sheltered positions on a rough bed and thus experience lower mobility, relative to the more exposed coarser grains, as observed for bedload transport. Thirdly, the virtual velocity of particles undergoing bedload transport has been found, in some instances, to be lower for finer clasts. We combine our data with previous studies of virtual velocity of bedload to develop, for the first time, an hypothesis for an holistic analysis of sediment movement in rivers.