Jamie C. Mitchell
Beth Israel Deaconess Medical Center
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Featured researches published by Jamie C. Mitchell.
Surgery | 2017
Deva Boone; Douglas Politz; Jose Lopez; Jamie C. Mitchell; Kevin Parrack; James Norman
Background. Guidelines for operative treatment of primary hyperparathyroidism include calcium levels >1 mg/dL above normal. We sought to determine whether greater calcium concentrations were associated with increased symptoms or disease severity. Methods. A retrospective review of a prospectively maintained database of adults undergoing parathyroidectomy for primary hyperparathyroidism, grouped according to greatest preoperative calcium level: those patients with calcium concentrations between 10.0 and 11.0 mg/dL and those with >11.0 mg/dL. We compared subjective symptoms and objective measures of disease severity. Results. The review included 20,081 adults who were split nearly evenly between calcium concentrations between 10.0 and 11.0 (10,430, 51.9%) and those with >11.0 mg/dL (9,651, 48.1%). In both groups, an absence of symptoms related to primary hyperparathyroidism was uncommon (<5%). All subjective and objective measures of disease severity were nearly identical with no significant differences (percentages for calcium concentrations between 10.0 and 11.0 and those with >11.0 mg/dL, respectively), including fatigue (72% for both groups), heartburn (37% vs 34%), bone pain (50% vs 48%), sleep disturbances (68% vs 65%), osteoporosis (40% in both groups), kidney stones (21% vs 22%), chronic kidney disease with glomerular filtration rate <60 (29% vs 32%), and hypertension (50% vs 53%). Conclusion. Serum calcium concentrations of greater than or less than 11 mg/dL are unrelated to symptoms and disease severity in primary hyperparathyroidism. There is no evidence to support a serum calcium threshold in parathyroidectomy guidelines.
Surgery | 2005
Jamie C. Mitchell; Frederick D. Grant; Amy Evenson; J.A. Parker; Per-Olof Hasselgren; Sareh Parangi
The International Journal of Biochemistry & Cell Biology | 2005
Amy Evenson; Moin U. Fareed; Michael J. Menconi; Jamie C. Mitchell; Per-Olof Hasselgren
Seminars in Ultrasound Ct and Mri | 2005
Jamie C. Mitchell; Sareh Parangi
Thyroid | 2005
Jamie C. Mitchell; Sareh Parangi
Journal of Surgical Research | 2004
Jamie C. Mitchell; Amy Evenson; N.E. Tawa
Current Surgery | 2004
Jamie C. Mitchell; Sareh Parangi
Journal of Surgical Research | 2004
Amy Evenson; Michael J. Menconi; Jamie C. Mitchell; P.J. Hasselgren
Archive | 2007
Jamie C. Mitchell; Anthony Hollenberg; Sareh Parangi
International Journal of Molecular Medicine | 2006
Amy Evenson; Jamie C. Mitchell; Wei Wei; Vitaliy Poylin; Sareh Parangi; Per-Olof Hasselgren