Jan Kristensen

5-Carboxy-8-hydroxyquinoline is a Broad Spectrum 2-Oxoglutarate Oxygenase Inhibitor which Causes Iron Translocation.

2-Oxoglutarate and iron dependent oxygenases are therapeutic targets for human diseases. Using a representative 2OG oxygenase panel, we compare the inhibitory activities of 5-carboxy-8-hydroxyquinoline (IOX1) and 4-carboxy-8-hydroxyquinoline (4C8HQ) with that of two other commonly used 2OG oxygenase inhibitors, N-oxalylglycine (NOG) and 2,4-pyridinedicarboxylic acid (2,4-PDCA). The results reveal that IOX1 has a broad spectrum of activity, as demonstrated by the inhibition of transcription factor hydroxylases, representatives of all 2OG dependent histone demethylase subfamilies, nucleic acid demethylases and γ-butyrobetaine hydroxylase. Cellular assays show that, unlike NOG and 2,4-PDCA, IOX1 is active against both cytosolic and nuclear 2OG oxygenases without ester derivatisation. Unexpectedly, crystallographic studies on these oxygenases demonstrate that IOX1, but not 4C8HQ, can cause translocation of the active site metal, revealing a rare example of protein ligand-induced metal movement.

On the non-locality of quasiconvexity

Abstract It is shown that in the class of smooth real-valued functions on n × m matrices (n ≥ 3, m ≥ 2) there can be no “local condition” which is equivalent to quasiconvexity.

The existence of regular boundary points for non-linear elliptic systems

Abstract We consider non-linear elliptic systems of the type with Hölder continuous dependence on (x, u), and give conditions guaranteeing that almost every boundary point is a regular point for the gradient of solutions to related Dirichlet problems. We also introduce a new comparison technique, in order to deal with difference quotients.

On the Morse-Sard property and level sets of Sobolev and BV functions.

We establish Luzin

On Rank One Convex Functions that are Homogeneous of Degree One

N

Regularity of minimizers of autonomous convex variational integrals

and Morse-Sard properties for

Gradient ranges of bumps on the plane

BV_2

The Trace Theorem, the Luzin N- and Morse–Sard Properties for the Sharp Case of Sobolev–Lorentz Mappings

-functions defined on open domains in the plane. Using these results we prove that almost all level sets are finite disjoint unions of Lipschitz arcs whose tangent vectors are of bounded variation. In the case of

A bridge between Dubovitskiĭ–Federer theorems and the coarea formula

W^{2,1}

The Singular Set of Minima of Integral Functionals

-functions we strengthen the conclusion and show that almost all level sets are finite disjoint unions of