Jan Thoen

Echocardiographic strain and strain-rate imaging: a new tool to study regional myocardial function

Ultrasonic imaging is the noninvasive clinical imaging modality of choice for diagnosing heart disease. At present, two-dimensional ultrasonic grayscale images provide a relatively cheap, fast, bedside method to study the morphology of the heart. Several methods have been proposed to assess myocardial function. These have been based on either grayscale or motion (velocity) information measured in real-time. However, the quantitative assessment of regional myocardial function remains an important goal in clinical cardiology. To do this, ultrasonic strain and strain-rate imaging have been introduced. In the clinical setting, these techniques currently only allow one component of the true three-dimensional deformation to be measured. Clinical, multidimensional strain (rate) information can currently thus only be obtained by combining data acquired using different transducer positions. Nevertheless, given the appropriate postprocessing, the clinical value of these techniques has already been shown. Moreover, multidimensional strain and strain-rate estimation of the heart in vivo by means of a single ultrasound acquisition has been shown to be feasible. In this paper, the new techniques of ultrasonic strain rate and strain imaging of the heart are reviewed in terms of definitions, data acquisition, strain-rate estimation, postprocessing, and parameter extraction. Their clinical validation and relevance are discussed using clinical examples on relevant cardiac pathology. Based on these examples, suggestions are made for future developments of these techniques.

Temperature dependence of the electrical conductivity of imidazolium ionic liquids

The electrical conductivities of 1-alkyl-3-methylimidazolium tetrafluoroborate ionic liquids and of 1-hexyl-3-methylimidazolium ionic liquids with different anions were determined in the temperature range between 123 and 393 K on the basis of dielectric measurements in the frequency range from 1 to 10(7) Hz. Most of the ionic liquids form a glass and the conductivity values obey the Vogel-Fulcher-Tammann equation. The glass transition temperatures are increasing with increasing length of the alkyl chain. The fragility is weakly dependent on the alkyl chain length but is highly sensitive to the structure of the anion.

Laser ultrasonic study of Lamb waves: determination of the thickness and velocities of a thin plate

Transient Lamb waves in a thin copper plate were generated and measured using a laser ultrasonic setup. A two-dimensional Fourier transform method has been employed to analyse the dispersion curves. This allowed a clear identification of multi-mode Lamb waves. Fitting of the dispersion curve allowed a direct determination of the thickness and bulk velocities, as well as the elastic constants. The obtained experimental results of Lamb waves on a copper plate show excellent agreement with the theoretical model.

Temperature-driven mixing-demixing behavior of binary mixtures of the ionic liquid choline bis(trifluoromethylsulfonyl)imide and water.

The ionic liquid (2-hydroxyethylammonium)trimethylammonium) bis(trifluoromethylsulfonyl)imide (choline bistriflimide) was obtained as a supercooled liquid at room temperature (melting point=30 degrees C). Crystals of choline bistriflimide suitable for structure determination were grown from the melt in situ on the X-ray diffractometer. The choline cation adopts a folded conformation, whereas the bistriflimide anion exhibits a transoid conformation. The choline cation and the bistriflimide anion are held together by hydrogen bonds between the hydroxyl proton and a sulfonyl oxygen atom. This hydrogen bonding is of importance for the temperature-dependent solubility properties of the ionic liquid. Choline bistriflimide is not miscible with water at room temperature, but forms one phase with water at temperatures above 72 degrees C (equals upper critical solution temperature). 1H NMR studies show that the hydrogen bonds between the choline cation and the bistriflimide anion are substantially weakened above this temperature. The thermophysical properties of water-choline bistriflimide binary mixtures were furthermore studied by a photopyroelectric technique and by adiabatic scanning calorimetry (ASC). By photothermal analysis, besides highly accurate values for the thermal conductivity and effusivity of choline bistriflimide at 30 degrees C, the detailed temperature dependence of both the thermal conductivity and effusivity of the upper and lower part of a critical water-choline bistriflimide mixture in the neighborhood of the mixing-demixing phase transition could be determined with high resolution and accuracy. Together with high resolution ASC data for the heat capacity, experimental values were obtained for the critical exponents alpha and beta, and for the critical amplitude ratio G+/G-. These three values were found to be consistent with theoretical expectations for a three dimensional Ising-type of critical behavior of binary liquid mixtures.

On the character of acoustic waves at the interface between hard and soft solids and liquids

Laser ultrasonics is used to optically excite and detect acoustic waves at the interface between a liquid and a solid or coated solid. Several case studies show that this technique is feasible to investigate experimentally the theoretically predicted fundamental properties of different aspects of interface waves at liquid-solid interfaces and to characterize the elastic properties of soft solids. The theoretical prediction that the leaky Rayleigh (LR)-type root of the characteristic determinant becomes forbidden when the shear velocity of the solid lies below the bulk velocity of the liquid was experimentally confirmed. The depth profiling and nondestructive testing potential of Scholte waves was experimentally illustrated and explained by the properties of the wave displacement profile.

Experimental Evidence for a Nematic to Smectic A Tricritical Point in Alkylcyanobiphenyl Mixtures

Abstract An adiabatic scanning calorimeter has been used to investigate the temperature dependence of the enthalpy and the heat capacity near the smectic A (A) to nematic (N) phase transition in mixtures of alkylcyanobiphenyl (nCB) liquid crystals. Mixtures of 8CB + 10 CB with small N-ranges undergo first-order transitions, but mixtures with large N-ranges exhibit continuous ones. A tricritical point could be located for the 10CB mole fraction of 0.3135. For a nearly tricritical mixture, a critical exponent α = 0.50 ± 0.02 has been observed. For mixtures with continuous AN transitions it is seen that this specific heat exponent α decreases with the width of the nematic range.

Absolute values of specific heat capacity and thermal conductivity of liquids from different modes of operation of a simple photopyroelectric setup

Photothermal techniques offer a nice tool for the determination of changes in thermal parameters of different types of samples. Using a very thin pyroelectric transducer, a very simple and versatile ac calorimeter can be built. The described inverse pyroelectric technique allows high-resolution ac-calorimetric measurements of the temperature dependence of the specific heat capacity. Since measuring frequencies up to a few hertz can be used, which are higher than in most alternative ac-calorimetric setups, noise can be reduced and measuring times shortened. With a small modification of the measurement cell, the determination of absolute specific heat capacity and thermal conductivity values of liquid samples was achieved. Comparison of the frequency response of the system with and without a solid thermal load in the neighborhood of the sample yields data with an accuracy of about 5% and 10% for specific heat capacity and thermal conductivity, respectively. If necessary, absolute values of specific heat cap...

Determination of the order parameter and its critical exponent for nCB (n=5–8) liquid crystals from refractive index data

We describe the order parameter S(T) of liquid crystals in the nematic state by a four-parameter expression which is consistent with mean-field theory. A two-step fitting method is applied to high resolution refractive index data for the nCB (n=5–8) liquid crystals, processed according to Vuks and Neugebauer models. We find quasi-universal parameter values. The average critical exponent is β=0.241±0.012, in agreement with the mean-field prediction for a tricritical point. Thus the temperature dependence of the nematic order parameter is quasi-tricritical in all cases. The order parameter at the effective transition point T** is S**=0.143±0.05 and the relative polarizability anisotropy Δα/⟨α⟩=0.69±0.03. We show that earlier results using the Haller approximation were too low (β=0.16–0.19) because of the assumption S**=0 and T**=T NI. The chosen fitting function provides the best description of S(T) both close and far from T**. For all parameters, the alternating odd–even effect with the number of C atoms in the alkyl chain is about ±5% except for S** for which it is ±30%. 6CB is singled out by a somewhat different set of fitting parameters. 8CB shows a pretransitional smectic behaviour starting from 4 K above the smectic–nematic transition point.

Determination of the viscous characteristic length in air‐filled porous materials by ultrasonic attenuation measurements

The concept of viscous characteristic length is used to describe the acoustical behavior of fluid‐saturated porous media in the high‐frequency regime. A method to determine this parameter consists of measuring the wave attenuation in the high‐frequency limit. This method has already been used for porous materials saturated by superfluid 2He. It is tested in the case of air‐filled absorbent materials in a frequency range of [50–600 kHz]. The thermal characteristic length is assumed to be known or measured independently. Two examples are presented. In the first one the method is usable and the viscous characteristic length Λ is deduced from the high‐frequency behavior of the attenuation per cycle. In the second example, an additional attenuation occurs at high frequencies and only an estimate of Λ can be given. Nevertheless, the estimation appears to be rather accurate. The values obtained by this method are compared to those determined by a nonlinear fit of the dispersion curves.

Theory of Scholte, leaky Rayleigh, and lateral wave excitation via the laser-induced thermoelastic effect

The analysis of the laser‐induced thermoelastic excitation of acoustic waves propagating along a plane interface between two elastic media is presented. The general solution for the interface motion is derived. The detailed description of the liquid–solid interface motion caused by the photoexcited leaky Rayleigh, Scholte and lateral wave in the liquid is given both in frequency and time domain. The presented theory predicts that laser‐induced thermoelastic stresses in the liquid and the solid can contribute in phase to the excitation of a Scholte wave and that the lateral wave excitation is suppressed when the light penetration depth and Scholte wave penetration depth in the liquid are equal. The obtained analytical solutions provide necessary theoretical background for the optimization of the laser‐induced generation of interface waves in experiments.