Jana Povová
University of Ostrava
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Featured researches published by Jana Povová.
Biomedical papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia | 2012
Jana Povová; Petr Ambroz; Michal Bar; Veronika Pavuková; Omar Sery; Hana Tomášková; Vladimir Janout
BACKGROUND Alzheimers disease (AD) is the most common form of dementia. It is a degenerative, incurable and terminal disease. The increasing prevalence of AD is, among other reasons, due to population aging, which is, to a certain extent, seen worldwide. Continuous advances in health care keep increasing life expectancy. Official statistics are likely to significantly underestimate the actual prevalence of AD. Alzheimers disease represents an important public health problem. Its aetiology is still unknown and for this reason, it is necessary to study all potential risk factors which may contribute to the development of this disease. METHODS We searched original and review articles addressing Alzheimers disease using key words Alzheimers disease, epidemiology, risk factors and prevention. We found and used one hundred and four references. CONCLUSIONS Based on epidemiological studies, genetic studies, neuroimaging methods and neuropathology research, three basic etiological hypotheses of the development of AD have been formulated: genetic, vascular and psychosocial. At present, the level of evidence is insufficient for the etiological role of other factors, such as nutrition, occupational exposure to various substances and inflammation. From the point of view of early diagnosis and application of primary or secondary prevention principles, genetic factors are the most important.
Behavioral and Brain Functions | 2015
Omar Šerý; Jan Lochman; Jana Povová; Vladimir Janout; Jiří Plesník; Vladimir J. Balcar
BackgroundThe objective of the study was to examine several polymorphisms in DISC1 and CTNX3 genes as possible risk factors in schizophrenia. DISC1 (disrupted-in-schizophrenia 1) has been studied extensively in relation to mental disease while CTXN3, has only recently emerged as a potential “candidate” gene in schizophrenia. CTXN3 resides in a genomic region (5q21-34) known to be associated with schizophrenia and encodes a protein cortexin 3 which is highly enriched in brain.MethodsWe used ethnically homogeneous samples of 175 male patients and 184 male control subjects. All patients were interviewed by two similarly qualified psychiatrists. Controls were interviewed by one of the authors (O.S.). Genotyping was performed, following amplification by polymerase chain reaction (PCR), using fragment analysis in a standard commercial setting (Applied Biosystems, USA).ResultsWe have found a statistically significant association between rs6595788 polymorphism of CTXN3 gene and the risk of schizophrenia; the presence of AG genotype increased the risk 1.5-fold. Polymorphisms in DISC1 gene showed only marginally statistically significant association with schizophrenia (rs17817356) or no association whatsoever (rs821597 and rs980989) while two polymorphisms (rs9661837 and rs3737597) were found to be only slightly polymorphic in the samples.ConclusionEvidence available in the literature suggests that altered expression of cortexin 3, either alone, or in parallel with changes in DISC1, could subtly perturb GABAergic neurotransmission and/or metabolism of amyloid precursor protein (APP) in developing brain, thus potentially exposing the affected individual to an increased risk of schizophrenia later in life.
Folia Neuropathologica | 2013
Omar Šerý; Jana Povová; Ivan Míšek; Lukáš Pešák; Vladimir Janout
Neuroendocrinology Letters | 2014
Omar Šerý; Lýdia Hlinecká; Vladimir J. Balcar; Vladimir Janout; Jana Povová
Journal of the Neurological Sciences | 2016
Omar Šerý; Lýdia Hlinecká; Jana Povová; Ondřej Bonczek; Tomáš Zeman; Vladimir Janout; Petr Ambroz; Naim Akhtar Khan; Vladimir J. Balcar
Neuroendocrinology Letters | 2014
Omar Šerý; Jana Povová; Vladimir J. Balcar
Neuro endocrinology letters | 2013
Jan Lochman; Jiří Plesník; Vladimir Janout; Jana Povová; Ivan Míšek; Dagmar Dvořáková; Omar Šerý
Journal of the Neurological Sciences | 2016
Omar Šerý; Lydia Hlinecká; Jana Povová; Ondřej Bonczek; Tomáš Zeman; Vladimir Janout; Petr Ambroz; Naim Akhtar Khan; Vladimir J. Balcar
Urologie pro praxi | 2015
Peter Dančík; Jana Povová; Kateřina Vařechová; Vladimir Janout
Hygiena | 2015
Jana Povová; Andrea Dalecká; Hana Tomášková; Kateřina Vařechová; Vladimir Janout