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Biomedical papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia | 2012

Epidemiological of and risk factors for Alzheimer‘s disease: A review

Jana Povová; Petr Ambroz; Michal Bar; Veronika Pavuková; Omar Sery; Hana Tomášková; Vladimir Janout

BACKGROUND Alzheimers disease (AD) is the most common form of dementia. It is a degenerative, incurable and terminal disease. The increasing prevalence of AD is, among other reasons, due to population aging, which is, to a certain extent, seen worldwide. Continuous advances in health care keep increasing life expectancy. Official statistics are likely to significantly underestimate the actual prevalence of AD. Alzheimers disease represents an important public health problem. Its aetiology is still unknown and for this reason, it is necessary to study all potential risk factors which may contribute to the development of this disease. METHODS We searched original and review articles addressing Alzheimers disease using key words Alzheimers disease, epidemiology, risk factors and prevention. We found and used one hundred and four references. CONCLUSIONS Based on epidemiological studies, genetic studies, neuroimaging methods and neuropathology research, three basic etiological hypotheses of the development of AD have been formulated: genetic, vascular and psychosocial. At present, the level of evidence is insufficient for the etiological role of other factors, such as nutrition, occupational exposure to various substances and inflammation. From the point of view of early diagnosis and application of primary or secondary prevention principles, genetic factors are the most important.


Behavioral and Brain Functions | 2015

Association between 5q23.2-located polymorphism of CTXN3 gene(Cortexin 3) and schizophrenia in European-Caucasian males;implications for the aetiology of schizophrenia

Omar Šerý; Jan Lochman; Jana Povová; Vladimir Janout; Jiří Plesník; Vladimir J. Balcar

BackgroundThe objective of the study was to examine several polymorphisms in DISC1 and CTNX3 genes as possible risk factors in schizophrenia. DISC1 (disrupted-in-schizophrenia 1) has been studied extensively in relation to mental disease while CTXN3, has only recently emerged as a potential “candidate” gene in schizophrenia. CTXN3 resides in a genomic region (5q21-34) known to be associated with schizophrenia and encodes a protein cortexin 3 which is highly enriched in brain.MethodsWe used ethnically homogeneous samples of 175 male patients and 184 male control subjects. All patients were interviewed by two similarly qualified psychiatrists. Controls were interviewed by one of the authors (O.S.). Genotyping was performed, following amplification by polymerase chain reaction (PCR), using fragment analysis in a standard commercial setting (Applied Biosystems, USA).ResultsWe have found a statistically significant association between rs6595788 polymorphism of CTXN3 gene and the risk of schizophrenia; the presence of AG genotype increased the risk 1.5-fold. Polymorphisms in DISC1 gene showed only marginally statistically significant association with schizophrenia (rs17817356) or no association whatsoever (rs821597 and rs980989) while two polymorphisms (rs9661837 and rs3737597) were found to be only slightly polymorphic in the samples.ConclusionEvidence available in the literature suggests that altered expression of cortexin 3, either alone, or in parallel with changes in DISC1, could subtly perturb GABAergic neurotransmission and/or metabolism of amyloid precursor protein (APP) in developing brain, thus potentially exposing the affected individual to an increased risk of schizophrenia later in life.


Folia Neuropathologica | 2013

Molecular mechanisms of neuropathological changes in Alzheimer`s disease: a review

Omar Šerý; Jana Povová; Ivan Míšek; Lukáš Pešák; Vladimir Janout


Neuroendocrinology Letters | 2014

Diabetes, hypertension and stroke - does Alzheimer protect you?

Omar Šerý; Lýdia Hlinecká; Vladimir J. Balcar; Vladimir Janout; Jana Povová


Journal of the Neurological Sciences | 2016

Arachidonate 5-lipoxygenase (ALOX5) gene polymorphism is associated with Alzheimer's disease and body mass index.

Omar Šerý; Lýdia Hlinecká; Jana Povová; Ondřej Bonczek; Tomáš Zeman; Vladimir Janout; Petr Ambroz; Naim Akhtar Khan; Vladimir J. Balcar


Neuroendocrinology Letters | 2014

Perspectives in genetic prediction of Alzheimer's disease

Omar Šerý; Jana Povová; Vladimir J. Balcar


Neuro endocrinology letters | 2013

Interactive effect of MTHFR and ADRA2A gene polymorphisms on pathogenesis of schizophrenia.

Jan Lochman; Jiří Plesník; Vladimir Janout; Jana Povová; Ivan Míšek; Dagmar Dvořáková; Omar Šerý


Journal of the Neurological Sciences | 2016

Corrigendum to ‘Arachidonate 5-Lipoxygenase (ALOX5) gene polymorphism is associated with Alzheimer's disease and body mass index [Šerý et al., J. Neurol. Sci. 362 (2016) 27–32]

Omar Šerý; Lydia Hlinecká; Jana Povová; Ondřej Bonczek; Tomáš Zeman; Vladimir Janout; Petr Ambroz; Naim Akhtar Khan; Vladimir J. Balcar


Urologie pro praxi | 2015

Urolitiáza a obezita

Peter Dančík; Jana Povová; Kateřina Vařechová; Vladimir Janout


Hygiena | 2015

Prevalence kuřáctví u studentů všeobecného lékařství na Ostravské univerzitě v Ostravě

Jana Povová; Andrea Dalecká; Hana Tomášková; Kateřina Vařechová; Vladimir Janout

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Ivan Míšek

Academy of Sciences of the Czech Republic

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