Jane V. Stiles
Duke University
Network
Latest external collaboration on country level. Dive into details by clicking on the dots.
Publication
Featured researches published by Jane V. Stiles.
Journal of Applied Physiology | 2011
Loretta G. Que; Jane V. Stiles; John S. Sundy; W. Michael Foster
Effect of laboratory exposure to O₃ (220 ppb) and filtered air (FA) on respiratory physiology were evaluated at two time points (acute and 1 day postexposure) in healthy cohort (n = 138, 18-35 yr, 40% women) comprised mainly of Caucasian (60%) and African American (33.3%) subjects. Randomized exposures had a crossover design and durations of 2.25 h that included rest and treadmill walking. Airway responsiveness (AHR) to methacholine (Mch) and permeability of respiratory epithelium (EI) to hydrophilic radiomarker ((99m)Tc-DTPA, MW = 492), were measured at 1-day postexposure. O₃ significantly affected FEV₁ and FVC indices acutely with mean decrements from pre-exposure values on the order of 7.7 to 8.8% and 1.8 to 2.3% at 1-day post. Acute FEV₁ and FVC decreases were most robust in African American male subjects. At 1-day post, O₃ induced significant changes in AHR (slope of Mch dose response curve) and EI (Tc(99m)-DTPA clearance half-time). Based on conventional thresholds of response and dichotomous classification of subjects as responders and nonresponders, sensitivity to O₃ was shown to be nonuniform. Acute decrements ≥ 15% in FEV₁, a doubling of Mch slope, or ≥ 15% increase in EI developed in 20.3%, 23.1%, and 25.9%, respectively, of subjects evaluated. Results demonstrate a diffuse sensitivity to O₃ and physiological responses, either acutely (decreases in FEV₁) or 1 day post (development of AHR or change in EI) occur differentially in healthy young adults. Random overlap among subjects classified as responsive for respective FEV₁, AHR, and EI endpoints suggests these are separate and independent phenotypes of O₃ exposure.
Magnetic Resonance Imaging | 2015
Mu He; Scott H. Robertson; S. Sivaram Kaushik; Matthew S. Freeman; Rohan S. Virgincar; John Davies; Jane V. Stiles; William M. Foster; H. Page McAdams; Bastiaan Driehuys
PURPOSE The aim of this study was to evaluate the effect of hyperpolarized (129)Xe dose on image signal-to-noise ratio (SNR) and ventilation defect conspicuity on both multi-slice gradient echo and isotropic 3D-radially acquired ventilation MRI. MATERIALS AND METHODS Ten non-smoking older subjects (ages 60.8±7.9years) underwent hyperpolarized (HP) (129)Xe ventilation MRI using both GRE and 3D-radial acquisitions, each tested using a 71ml (high) and 24ml (low) dose equivalent (DE) of fully polarized, fully enriched (129)Xe. For all images SNR and ventilation defect percentage (VDP) were calculated. RESULTS Normalized SNR (SNRn), obtained by dividing SNR by voxel volume and dose was higher for high-DE GRE acquisitions (SNRn=1.9±0.8ml(-2)) than low-DE GRE scans (SNRn=0.8±0.2ml(-2)). Radially acquired images exhibited a more consistent, albeit lower SNRn (High-DE: SNRn=0.5±0.1ml(-2), low-DE: SNRn=0.5±0.2ml(-2)). VDP was indistinguishable across all scans. CONCLUSIONS These results suggest that images acquired using the high-DE GRE sequence provided the highest SNRn, which was in agreement with previous reports in the literature. 3D-radial images had lower SNRn, but have advantages for visual display, monitoring magnetization dynamics, and visualizing physiological gradients. By evaluating normalized SNR in the context of dose-equivalent formalism, it should be possible to predict (129)Xe dose requirements and quantify the benefits of more efficient transmit/receive coils, field strengths, and pulse sequences.
Journal of Applied Physiology | 2013
S. Sivaram Kaushik; Matthew S. Freeman; Zackary I. Cleveland; John Davies; Jane V. Stiles; Rohan S. Virgincar; Scott H. Robertson; Mu He; Kevin T. Kelly; W. Michael Foster; H. Page McAdams; Bastiaan Driehuys
Journal of Applied Physiology | 2014
S. Sivaram Kaushik; Matthew S. Freeman; Suk W. Yoon; Maria Liljeroth; Jane V. Stiles; Justus E. Roos; W. Sivaram Michael Foster; Craig R. Rackley; H P McAdams; Bastiaan Driehuys
The Journal of Allergy and Clinical Immunology | 2016
Benjamin W. Frush; Zhuowei Li; Jane V. Stiles; Sarah F. Cotter; Scott Shofer; W. Michael Foster; John W. Hollingsworth; Robert M. Tighe
Archive | 2015
Bruce Thompson; Sylvia Verbanck; Daniel Schuermans; Sophie Van Malderen; Walter Vincken; I. Tillie-Leblond; D. Dusser; Justus E. Roos; W. Sivaram; Michael Foster; Craig R. Rackley; H P McAdams; Matthew S. Freeman; Suk W. Yoon; Maria Liljeroth; Jane V. Stiles
Archive | 2015
Jose G. Venegas; Marcos F. Vidal; J. Wellman; Tilo Winkler; Eduardo Lv Costa; Guido Musch; R. Scott; Bastiaan Driehuys; Rohan S. Virgincar; Scott H. Robertson; Kevin T. Kelly; W. Michael Foster; S. Sivaram Kaushik; Matthew S. Freeman; Zackary I. Cleveland; John Davies; Jane V. Stiles; Anders Larsson; Gaetano Perchiazzi; Göran Hedenstierna; Savino Derosa; João Batista Borges; Monica Segelsjö; Angela Tannoia; Mariangela Pellegrini
american thoracic society international conference | 2011
Shuo Zheng; Erin N. Potts; Jane V. Stiles; Judith A. Voynow
The FASEB Journal | 2011
W. Michael Foster; Erin N. Potts; Zhuowei Li; Jane V. Stiles; John W. Hollingsworth
american thoracic society international conference | 2010
Stephanie Norfolk; Momen M. Wahidi; Jane V. Stiles; William M. Foster; Scott Shofer