Janet Squires

Use of Skeletal Surveys to Evaluate for Physical Abuse: Analysis of 703 Consecutive Skeletal Surveys

OBJECTIVES: The goals were to assess the use of the skeletal survey (SS) to evaluate for physical abuse in a large consecutive sample, to identify characteristics of children most likely to have unsuspected fractures, and to determine how often SS results influenced directly the decision to make a diagnosis of abuse. METHODS: A retrospective, descriptive study of a consecutive sample of children who underwent an SS at a single childrens hospital over 4 years was performed. Data on demographic characteristics, clinical presentation, SS results, and effects of SS results on clinical diagnoses were collected. A positive SS result was defined as a SS which identified a previously unsuspected fracture(s). RESULTS: Of the 703 SSs, 10.8% yielded positive results. Children <6 months of age, children with an apparent life-threatening event or seizure, and children with suspected abusive head trauma had the highest rates of positive SS results. Of children with positive SS results, 79% had ≥1 healing fracture. CONCLUSIONS: This is the largest study to date to describe the use of the SS. Almost 11% of SS results were positive. The SS results influenced directly the decision to make a diagnosis of abuse for 50% of children with positive SS results. These data, combined with the high morbidity rates for missed abuse and the large proportion of children with healing fractures detected through SS, suggest that broader use of SS, particularly for high-risk populations, may be warranted.

Azithromycin therapy for Cryptosporidium parvum infection in four children infected with human immunodeficiency virus

Cryptosporidium parvum intestinal infection in immunodeficient patients can cause severe intestinal fluid losses with severe dehydration or chronic diarrhea with malnutrition. Therapies tried in human beings and animals include paromomycin, clarithromycin, azithromycin, octreotide, hyperimmune bovine colostrum, and bovine transfer factor. No specific therapy has been found to be consistently beneficial to children. We report azithromycin treatment of four children with acquired immunodeficiency syndrome who had severe diarrheal illnesses in which Cryptosporidium parvum was the sole pathogen detected. Three of these children had a marked decrease in stool volume and frequency within 36 hours of initiating therapy and resolution of diarrhea within 5 days; Cryptosporidium organisms became undetectable on examination of stool or colonic biopsy or by both after therapy was discontinued. A fourth patient required prolonged therapy with azithromycin to achieve clearance. Azithromycin therapy should be considered for immunocompromised patients with intestinal Cryptosporidium infection.

ASSESSING THE USE OF FOLLOW-UP SKELETAL SURVEYS IN CHILDREN WITH SUSPECTED PHYSICAL ABUSE

BACKGROUND Child physical abuse is an important cause of morbidity and mortality in young children. The skeletal survey (SS) is considered a mandatory part of the evaluation for suspected physical abuse in young children. Literature suggests that a follow-up SS performed 10 to 21 days after the initial SS can provide important additional information, but previous studies evaluating the follow-up SS have been small and included very selective patient populations. METHODS A retrospective descriptive study of a consecutive sample of children who underwent an initial SS and a follow-up SS at a single children’s hospital during a 7-year period. Data on demographics, clinical presentation, results, and effect of the follow-up SS on clinical diagnosis were collected. RESULTS Of the 1470 children who underwent an initial SS, 11% (169 of 1470 children) also underwent a follow-up SS. The mean age of the children who underwent both an initial SS and a follow-up SS was 5.8 months. Fourteen percent of the follow-up SS identified previously unrecognized fractures; all of which were healing. There were eight children in whom the information obtained from the follow-up SS resulted in a diagnosis of definite physical abuse; all eight children were younger than 12 months, and in six of these cases, the initial SS did not demonstrate any fractures. CONCLUSION Only a small proportion of children who undergo an initial SS also undergo a follow-up SS. The relatively high proportion of follow-up SS that demonstrated previously unrecognized fracture(s), the young age of children undergoing the follow-up SS, and the high morbidity and mortality of unrecognized/missed child physical abuse in this age group suggest that the follow-up SS should be a routine part of the evaluation of child physical abuse. LEVEL OF EVIDENCE III, observational study.

Parental Refusal of a Liver Transplant for a Child With Biliary Atresia

Pediatricians are required by law to notify child protection agencies if parents are neglecting their child’s medical needs. Sometimes, however, it is difficult to determine when a particular parental choice ought to be reported. If the treatment is standard therapy and the consequences of nontreatment are dire, than parental refusal is usually considered neglectful. Organ transplants, however, represent a unique situation for 2 reasons. First, because there is a dire scarcity of organs, there are more people who need organs than there are organs to transplant. In this situation, it seems odd to force a transplant on a child whose parents do not want it, knowing that other parents are eager to have their child undergo a transplant. Second, transplantation is risky and requires lifelong follow-up and treatment. Thus, parental cooperation is essential. We present a case of a child who needs a liver transplant and whose parents refuse, and ask 2 surgeons, a gastroenterologist, and a child abuse specialist to comment on the case. David C. Cronin is director of the liver transplant program at the Medical College of Wisconsin. Robert Squires is a gastroenterologist, George Mazariegos is a transplant surgeon, and Janet Squires is chief of the child advocacy center, all at the University of Pittsburgh. A 10-month-old girl, Baby A, was admitted to the hospital because of worsening jaundice. She had been diagnosed with biliary atresia at 1 month of age, and a Kasai procedure was performed when she was 10 weeks old. Since then, she had been failing to thrive and had worsening jaundice. On the current admission, the patient’s weight was 8 kg (<5th percentile). Her abdominal girth was 50 cm with significant hepatomegaly. Her total protein was 6.0 g/dL with an albumin level of 2.5 g/dL. Alkaline phosphatase was 355 U/L, aspartate aminotransferase was … Address correspondence to John D. Lantos, MD, University of Missouri, Kansas City, 2401 Gillham Rd, Kansas City, MO 64108. E-mail: jlantos{at}cmh.edu

A Review of Munchausen Syndrome by Proxy

Munchausen syndrome by proxy was described 35 years ago,1 and yet it remains a complicated, controversial, and confusing condition. The term was initially limited to circumstances in which a caregiver surreptitiously injured the child or the child’s symptoms were fabricated, both leading to unnecessary or potentially harmful medical care. Over time, the spectrum of Munchausen syndrome by proxy (MSP) has expanded. Clinicians frequently use the term to describe cases in which a child’s medical symptoms are emphasized and exaggerated by an unsatisfied adult caregiver, which enters the child into a pattern of increasing tests and interventions. At some point, and usually only in retrospect, physicians realize the medical care itself was not medically justified and caused real or potential harm to the child. Primary care physicians are uniquely positioned to identify potential warning signs of MSP. Whether the child’s illness is inflicted directly by the family, or through unnecessary tests ordered or performed by health professionals, early recognition of risk factors and interruption of family and physician behaviors can stop an increasingly dangerous situation for a child. We will discuss elements of the contemporary health care system, which may facilitate “over medicalization” that places the child at risk for injury. Heightened awareness of the role health care providers’ play in perpetuation of some cases of MSP may help reduce morbidity and mortality.

Mother-to-child transmission of the human immunodeficiency virus in Texas

Background. The Pediatric Spectrum of HIV Diseases (PSD) project has been collecting data on HIV-exposed children in Texas since 1989. These data have now been analyzed to describe mother-to-child transmission in Texas and to provide much needed information on the magnitude of the pediatric HIV epidemic in the state. Methods. We examined trends in the numbers of perinatally exposed children and perinatally acquired cases of HIV in the Texas PSD cohort. We calculated transmission rates and relative risks for 656 children born from January, 1995, to July, 1998, that received all or part of the ACTG 076 regimen. Results. Only a small proportion (38%) of pairs of an HIV-infected mother and her HIV-exposed child received the full AIDS Clinical Trial Group 076 (ACTG 076) regimen; only 73% of the mothers received at least some prenatal care. In recent years, however, the numbers of perinatally exposed children and perinatally acquired cases of HIV have decreased in Texas. Univariate analyses showed that a reduction in the vertical transmission of HIV was associated with receipt of a full ACTG 076 regimen, receipt of a partial ACTG 076 regimen and residence in Dallas County. Conclusions. Findings identify a gap in meeting the health care needs of pregnant HIV-infected women and suggest missed opportunities to prevent mother-to-child transmission of HIV. At the same time this study confirms progress in prevention efforts to reduce mother-to-child transmission of HIV in Texas.

Increased serum creatine phosphokinase in a child with bruising due to physical abuse

Abstract Bruising is a frequent and often sentinel injury in children who are victims of physical abuse. Children who are evaluated in an emergency department for bruising, which may be due to abuse, present a challenge to physicians; the injuries themselves are medically minor and their severity can only be described qualitatively with photographs. Nonetheless, bruising in an infant or bruising in unusual locations in young children can indicate violence and risk. These children also present a challenge to the Child Protective Services system because the injuries generally resolve quickly without medical treatment and do not result in long-term sequelae. Creatine phosphokinase (CPK) is released from injured muscle and results in increased serum CPK concentrations. We report on a case of isolated bruising due to child physical abuse in which serum CPK concentrations were markedly increased, demonstrating clinically unsuspected rhabdomyolysis. The increased serum CPK concentrations provided important quantitative information about the seriousness of the bruising. A subsequent chart review of children evaluated by our hospital’s child protection team for isolated bruising during a 6-year period demonstrated that there were other children with bruising due to abuse who also had increased serum CPK concentrations. This information suggests that increased serum CPK in children with bruising due to abuse may be more common than previously thought and that this information may have the potential to be used to provide quantitative, objective information about the seriousness of the bruising. We recommend that physicians consider measuring serum CPK in children with bruising due to physical abuse.