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Featured researches published by Janice M. Klunder.


Bioorganic & Medicinal Chemistry Letters | 1998

Potent and selective inhibitors of the proteasome: Dipeptidyl boronic acids

Julian Adams; Mark L. Behnke; Shaowu Chen; Amy A. Cruickshank; Lawrence R. Dick; Louis Grenier; Janice M. Klunder; Yu-Ting Ma; Louis Plamondon; Ross L. Stein

Potent and selective dipeptidyl boronic acid proteasome inhibitors are described. As compared to peptidyl aldehyde compounds, boronic acids in this series display dramatically enhanced potency. Compounds such as 15 are promising new therapeutics for treatment of cancer and inflammatory diseases.


Journal of Medicinal Chemistry | 1991

Novel non-nucleoside inhibitors of HIV-1 reverse transcriptase. 1. Tricyclic pyridobenzo- and dipyridodiazepinones.

Karl D. Hargrave; John R. Proudfoot; Karl G. Grozinger; Ernest Cullen; Suresh R. Kapadia; Usha R. Patel; Victor Fuchs; Scott C. Mauldin; Jana Vitous; Mark L. Behnke; Janice M. Klunder; Kollol Pal; Jerry W. Skiles; Daniel W. McNeil; Janice M. Rose; Grace C. Chow; Mark T. Skoog; Joe C. Wu; Gunther Schmidt; Wolfhard Engel; Wolfgang Eberlein; Tracy D. Saboe; Scot Campbell; Alan S. Rosenthal; Julian Adams


Journal of Medicinal Chemistry | 1992

Novel non-nucleoside inhibitors of HIV-1 reverse transcriptase. 2. Tricyclic pyridobenzoxazepinones and dibenzoxazepinones.

Janice M. Klunder; Karl D. Hargrave; West M; Ernest Cullen; Kollol Pal; Mark L. Behnke; Kapadia; Daniel W. McNeil; Joe C. Wu; Grace C. Chow


Journal of Medicinal Chemistry | 1998

Novel nonnucleoside inhibitors of HIV-1 reverse transcriptase. 7. 8-Arylethyldipyridodiazepinones as potent broad-spectrum inhibitors of wild-type and mutant enzymes

Janice M. Klunder; Maryann Hoermann; Charles L. Cywin; Eva David; Janice R. Brickwood; Racheline Schwartz; Kevin J. Barringer; Daniel Pauletti; Cheng-Kon Shih; David A. Erickson; Christopher L. Sorge; David P. Joseph; Susan E. Hattox; Julian Adams; Peter M. Grob


Journal of Medicinal Chemistry | 1998

Novel nonnucleoside inhibitors of HIV-1 reverse transcriptase. 8. 8-Aryloxymethyl- and 8-arylthiomethyldipyridodiazepinones.

Charles L. Cywin; Janice M. Klunder; Maryann Hoermann; Janice R. Brickwood; Eva David; Peter M. Grob; Racheline Schwartz; Daniel Pauletti; Kevin J. Barringer; Cheng-Kon Shih; Christopher L. Sorge; David A. Erickson; David P. Joseph; Susan E. Hattox


Journal of Heterocyclic Chemistry | 1995

Sommelet-hauser rearrangement of an ammonium ylide derived from the HIV-1 reverse transcriptase inhibitor nevirapine

Janice M. Klunder


Archive | 1996

8-Arylalkyl- and 8-arylheteroalkyl-5, 11-dihydro-6H-dipyrido-[3,2-b:2', 3'-e][1,4]diazepines and their use in the prevention or treatment of HIV infection

Charles L. Cywin; Maryann Hoermann; Janice M. Klunder


Archive | 1996

8-arylalkyl- and 8-arylheteroalkyl-5,11-dihydro-6H-dipyrido 3,2-B:2',3'-e! 1!diazepines and their use in the treatment of HIV-1 infection

Charles L. Cywin; Maryann Hoermann; Janice M. Klunder


Archive | 1996

8-arilalquil- y 8-arilheteroalquil-5,11-dihidro-6h-dipirido-(3,2-b:2',3'-e)(1,4)diazepinas y su uso en la prevencion o tratamiento de infecciones por hiv.

Charles L. Cywin; Maryann Hoermann; Janice M. Klunder


Archive | 1996

8-Arylalkyl- und 8-Arylheteroalkyl-5, 11-dihydro-6H-dipyrido-(3,2-b:2', 3'-e)(1,4)diazepine und ihre Verwendung zur Vorbeugung oder Behandlung von HIV-Infektion 8-arylalkyl- and 8-arylheteroalkyl-5, 11-dihydro-6H-dipyrido (3,2-b: 2 ', 3'-e) (1,4) diazepines and their use for the prevention or treatment of HIV infection

Charles L. Cywin; Maryann Hoermann; Janice M. Klunder

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