János Gyenis

Encapsulation of human serum albumin in submicrometer magnetic poly(lactide-co-glycolide) particles as a model system for targeted drug delivery

Abstract Two types of iron oxide nanoparticles were synthesized by coprecipitation of Fe(II) and Fe(III) chlorides: water-dispersible γ-Fe2O3 and organic solvent-dispersible oleic acid-coated Fe3O4 particles. The nanoparticles, together with human serum albumin (HSA) serving as a model for a protein-type drug, were then incorporated in poly(lactide-co-glycolide) (PLGA) particles using double emulsion solvent evaporation technique. Morphology, size and particle size distribution of the resulting particles was analyzed by electron microscopy and dynamic light scattering. Iron oxide and HSA encapsulating efficiency was determined by Prussian Blue staining and micro-BCA assay, respectively.

Thermal Energy Storage By Microcomposite Of A Phase Change Material And Ethyl Cellulose

Abstract Phase change materials (PCMs) are capable of storing and releasing large amounts of latent heat thermal energy when undergoes phase change. They are developed for various building applications such as thermal energy storage, thermal protection, cooling, air-conditioning, waste heat recovery and for solar heating systems. Paraffin PCMs have low cost and a moderate thermal energy density, though a low thermal conductivity. PCM microencapsulation is one of the best tools to enhance the heat transfer rate by enlarging the surface area. In this work ethyl cellulose as an environmental friendly encapsulating material was used to entrap n-hexadecane PCM by an emulsion-solvent evaporation method using poly(vinyl alcohol) (PVA), Tween 80 or poly(methacrylic acid sodium salt) (PMAA) emulsifier. The structure of the forming microparticles was predicted by determining the interfacial tensions between the phases. Both theoretically and in the experiments, composites prepared with PMAA showed the most desirable properties regarding the size (average: 80 m) and the latent heat storage capacity (of melting and freezing were 111.4 J/g and 117.9 J/g, respectively), furthermore, there was no significant temperature and enthalpy change observed after 1000 heating-cooling thermal cycles, thus, this microcomposite can be considered as suitable encapsulated PCM for thermal energy storage applications.