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Dive into the research topics where János Szepesi is active.

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Featured researches published by János Szepesi.


Oncogene | 1998

DOC-2/hDab2, a candidate tumor suppressor gene involved in the development of gestational trophoblastic diseases

Vilmos Fülöp; Cristiano V. Colitti; David R. Genest; Ross S. Berkowitz; Gary K. Yiu; Shu Wing Ng; János Szepesi; Samuel C. Mok

Gestational trophoblastic diseases comprise a spectrum of interrelated diseases including partial mole, complete mole and gestational choriocarcinoma. Using reverse transcriptase PCR (RT–PCR) analysis, we identified higher levels of DOC-2/hDab2 expression in the normal trophoblast cells in culture than in choriocarcinoma cell lines. Subsequent study using immunohistochemistry showed high levels of DOC-2/hDab2 protein expression in normal trophoblast tissues but significantly lower levels of expression in gestational trophoblastic disease tissues, particularly in complete mole and choriocarcinoma. When DOC-2/hDab2 was transfected into the choriocarcinoma cell lines, Jar, JEG and BeWo, the stable transfectants showed significantly reduced growth rate in culture. These data suggest that down regulation of DOC-2/hDab2 may play an important role in the development of gestational trophoblastic diseases.


European Journal of Obstetrics & Gynecology and Reproductive Biology | 2004

How long should patients be followed after molar pregnancy? Analysis of serum hCG follow-up data.

József Bátorfi; György Végh; János Szepesi; Ivan Szigetvari; József Doszpod; Vilmos Fülöp

Abstract Objective : We analyzed human chorionic gonadotropin (hCG) follow-up data of patients with molar pregnancy. Women often do not complete recommended post-disease screening. Our purpose was to determine if continuing follow up of uncomplicated molar cases beyond attaining undetectable hCG levels is necessary for detecting relapse of gestational trophoblastic disease. Study design : One hundred fifty patients treated at Hungarian National Health Center were analyzed. Those who developed persistent disease before hCG had become undetectable were excluded from further analysis ( n =24; 16%). Results : Among 126 uncomplicated cases, 72 patients (57%) completed follow up, and 54 (43%) discontinued their protocol before it had been completed. Of 120 patients who achieved at least one undetectable hCG level, none had any evidence of relapse. Conclusion : In uncomplicated hydatidiform mole, our analysis indicates that once undetectable serum hCG levels are attained, relapse is unlikely. Although further monthly checks are advisable, the likelihood of recurrence appears very low.


Obstetrical & Gynecological Survey | 2004

How Long Should Patients Be Followed After Molar Pregnancy? Analysis of Serum hCG Follow-Up Data

József Bátorfi; György Végh; János Szepesi; Ivan Szigetvari; József Doszpod; Vilmos Fülöp

OBJECTIVE We analyzed human chorionic gonadotropin (hCG) follow-up data of patients with molar pregnancy. Women often do not complete recommended post-disease screening. Our purpose was to determine if continuing follow up of uncomplicated molar cases beyond attaining undetectable hCG levels is necessary for detecting relapse of gestational trophoblastic disease. STUDY DESIGN One hundred fifty patients treated at Hungarian National Health Center were analyzed. Those who developed persistent disease before hCG had become undetectable were excluded from further analysis (n=24; 16%). RESULTS Among 126 uncomplicated cases, 72 patients (57%) completed follow up, and 54 (43%) discontinued their protocol before it had been completed. Of 120 patients who achieved at least one undetectable hCG level, none had any evidence of relapse. CONCLUSION In uncomplicated hydatidiform mole, our analysis indicates that once undetectable serum hCG levels are attained, relapse is unlikely. Although further monthly checks are advisable, the likelihood of recurrence appears very low.


Gynecologic and Obstetric Investigation | 1992

Tetraploidy in human placenta. A dilemma in molar and non-molar pregnancies

András Tóth; Gabriella Arató; János Szepesi; Hajdu K; Ivan Szigetvari; János F. László

17 cases of partial molar pregnancy were analysed cytogenetically by the direct-preparation method. Eight partial moles were triploid, 7 diploid/tetraploid mosaic, and 2 tetraploid. In the course of prenatal cytogenetic screening, out of 1,263 chorionic villus samplings, 2 tetraploid and 1 diploid/tetraploid cases were found. These cases of partial moles do not fit into the usual patterns of triploid partial moles. The findings presented here suggest that different causative factors may be involved in the origin of molar degenerations. These results also call to attention that tetraploidy is an existent and relatively common abnormality.


Placenta | 1987

Direct chromosomal preparation for studying hydatidiform moles

A. Tóth; János Szepesi; I. Szigetvari; J. László

This report describes a simple direct method to obtain chromosomes from hydatidiform moles. Of 24 moles, 20 have been successfully karyotyped by this method. Of the 20 cases, 14 were complete and six were partial. The karyotype of complete moles was invariably diploid. Three of the partial moles were triploid (69,XXX), but three showed diploid/tetraploid mosaicism.


Journal of Reproductive Medicine | 2010

30 years' experience in the treatment of low-risk gestational trophoblastic neoplasia in Hungary

Vilmos Fülöp; Ivan Szigetvari; János Szepesi; György Végh; József Bátorfi; Zoltan Nagymanyoki; Miklós Török; Ross S. Berkowitz


Journal of Reproductive Medicine | 2012

Clinical epidemiology and management of gestational trophoblastic neoplasia in Hungary in the past 34 years.

Vilmos Fülöp; Ivan Szigetvari; János Szepesi; György Végh; Margit Singh; Ross S. Berkowitz


Journal of Reproductive Medicine | 2016

The role of surgery in the management of gestational trophoblastic neoplasia: The Hungarian experience

Vilmos Fülöp; Ivan Szigetvari; János Szepesi; György Végh; László Zsirai; Ross S. Berkowitz


Journal of Reproductive Medicine | 2008

Diagnosis and treatment of high-risk metastatic gestational trophoblastic neoplasia in Hungary.

Vilmos Fülöp; Ivan Szigetvari; János Szepesi; Miklós Török; Ross S. Berkowitz


Journal of Reproductive Medicine | 2006

25 years' experience in the treatment of gestational trophoblastic neoplasia in Hungary.

Ivan Szigetvari; János Szepesi; György Végh; József Bátorfi; Gabriella Arató; Istvan Gati; Ross S. Berkowitz; Vilmos Fülöp

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Ross S. Berkowitz

Brigham and Women's Hospital

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I. Gati

Semmelweis University

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