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Dive into the research topics where Jaqueline Bohrer Schuch is active.

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Featured researches published by Jaqueline Bohrer Schuch.


Nutrition Metabolism and Cardiovascular Diseases | 2011

The influence of the S19W SNP of the APOA5 gene on triglyceride levels in southern Brazil: Interactions with the APOE gene, sex and menopause status

F.M. De Andrade; Sharbel Weidner Maluf; Jaqueline Bohrer Schuch; Francine Voigt; Alessandra Chiele Barros; Juliana Faggion Lucatelli; Mara H. Hutz

BACKGROUND AND AIMS Hypertriglyceridemia is an important independent risk factor for coronary artery diseases and is determined by a wide range of factors, both genetic and exogenous. The A5 apolipoprotein, which is associated with the synthesis and removal of triglycerides (TG), is encoded by the APOA5 gene. One of the polymorphisms of this gene that has been the focus of a large number of studies, and which appears to be associated with increased TG, is S19W (rs 3135506). In this study, we examined the influence of this single nucleotide polymorphism (SNP) on TG levels of a sample of southern Brazilians. METHODS AND RESULTS Samples obtained from 567 people of European descent were genotyped; interactions between this variant and anthropometric variables were analyzed, and the effects of lifestyle, sex, menopause, and variations of the APOE gene were evaluated. We found that the 19W allele is associated with increased TG (p = 0.025) and that this influence was modulated by sex (p = 0.003), menopause (p = 0.022) and the presence of the E*4 allele (p = 0.027). CONCLUSION Our data showed, for the first time, the importance and magnitude of the influence of the S19W variant in a southern Brazilian population.


Nutrition Research | 2014

SLC30A3 and SEP15 gene polymorphisms influence the serum concentrations of zinc and selenium in mature adults

Tatiane Jacobsen da Rocha; Camila Korb; Jaqueline Bohrer Schuch; Daiani Pires Bamberg; Fabiana Michelsen de Andrade; Marilu Fiegenbaum

Because of their numerous roles in several biological processes, zinc and selenium are the most commonly studied micronutrients in the elderly. Therefore, we hypothesized that the polymorphisms in the genes that are responsible for the transport of zinc and selenium may have a genotype-dependent effect on the serum concentration of these micronutrients. The objective of this study was to determine the effects of solute carrier family 30 member 3 (SLC30A3) and 15-kd selenoprotein (SEP15) polymorphisms on zinc and selenium concentrations, respectively, in the serum. This cross-sectional study included 110 individuals who were aged 50 years or older. Serum micronutrient concentrations were determined by flame atomic absorption spectrophotometry (for zinc) and by atomic absorption spectrophotometry with a graphite furnace (for selenium). The single-nucleotide polymorphisms, rs73924411 and rs11126936 of the SLC30A3 gene and rs5859, rs5854, and rs561104 of the SEP15 gene, were examined by real-time polymerase chain reaction. Regarding rs11126936, the serum zinc concentration was lower in CC homozygotes (0.75 ± 0.31 mg/L) than in A carriers (0.89 ± 0.28 mg/L, P = .016). Concerning rs561104, the serum selenium concentration was higher in CC homozygotes (5.65 ± 1.11 μg/dL) compared with T carriers (4.88 ± 1.25 μg/dL, P = .044). Our results demonstrate the influence of SLC30A3 and SEP15 gene polymorphisms on the serum concentrations of zinc and selenium, respectively. The effects of these associations should be further investigated to help elucidate the modes of action of trace elements and to identify biomarkers, which could ultimately define the optimal intake of these micronutrients at the molecular level. More research must be performed before the roles of these polymorphisms in the serum concentrations of zinc and selenium can be fully understood.


Biochemical Genetics | 2010

The influence of nutrigenetics on the lipid profile: interaction between genes and dietary habits.

Fabiana Michelsen de Andrade; Andréa C. Bulhões; Sharbel Weidner Maluf; Jaqueline Bohrer Schuch; Francine Voigt; Juliana Faggion Lucatelli; Alessandra Chiele Barros; Mara H. Hutz


Revista Brasileira de Biociências | 2010

Nutrigenética: a interação entre hábitos alimentares e o perfil genético individual

Jaqueline Bohrer Schuch; Francine Voigt; Sharbel Weidner Maluf; Fabiana Michelsen de Andrade


Age | 2014

ACE polymorphism and use of ACE inhibitors: effects on memory performance.

Jaqueline Bohrer Schuch; Pamela Camini Constantin; Vanessa Kappel da Silva; Camila Korb; Daiani Pires Bamberg; Tatiane Jacobsen da Rocha; Marilu Fiegenbaum; Alcyr Oliveira; Luciana Tisser; Fabiana Michelsen de Andrade


Revista Brasileira de Biociências | 2011

A influência genética sobre a memória humana: uma revisão

Fabiana Michelsen de Andrade; Vanessa Kappel da Silva; Jaqueline Bohrer Schuch


Revista Brasileira de Biociências | 2010

Nutrigenetics: the interaction between diet habits and the individual genetic profile.

Jaqueline Bohrer Schuch; Francine Voigt; Sharbel Weidner Maluf; F. M. de Andrade


Archive | 2009

INFLUÊNCIA DO POLIMORFISMO DO GENE ECA SOBRE ESCORES DE MEMÓRIA NA TERCEIRA IDADE

Jordana Tochetto Lizot; Adriana Freitag dos Santos; Fernanda Dallacosta; Jaqueline Bohrer Schuch; Luciana Alves; Priscilla Schafer; Regina Lopes Lino; Vanessa Kappel da Silva


Archive | 2009

INVESTIGAÇÃO DA INFLUÊNCIA DO GENE APOE SOBRE ESCORES DE MEMÓRIA EM IDOSOS

Vanessa Kappel da Silva; Adriana Freitag dos Santos; Fernanda Dallacosta; Fernanda da Silva Machado; Jaqueline Bohrer Schuch; Luciana Tisser; Priscila Schafer; Regina Lopes Lino


Archive | 2007

Interação nutrigenética entre o polimorfismo -1131t/c do gene da apoav e o consumo alimentar na determinação dos níveis de triglicerídeos

Jaqueline Bohrer Schuch; Juliana Faggion Lucatelli; Alessandra Chiele Barros; Andréa C. Bulhões

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Mara H. Hutz

Universidade Federal do Rio Grande do Sul

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Sharbel Weidner Maluf

Universidade Federal do Rio Grande do Sul

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