Jari Lipsanen

Brain atrophy accelerates cognitive decline in cerebral small vessel disease: The LADIS study

Objective: To examine the independent contributions and combined interactions of medial temporal lobe atrophy (MTA), cortical and subcortical atrophy, and white matter lesion (WML) volume in longitudinal cognitive performance. Methods: A total of 477 subjects with age-related WML were evaluated with brain MRI and annual neuropsychological examinations in 3-year follow-up. Baseline MRI determinants of cognitive decline were analyzed with linear mixed models controlling for multiple confounders. Results: MTA and subcortical atrophy predicted significantly steeper rate of decline in global cognitive measures as well as compound scores for psychomotor speed, executive functions, and memory after adjusting for age, gender, education, lacunes/infarcts, and WML volume. Cortical atrophy independently predicted decline in psychomotor speed. WML volume remained significantly associated with cognitive decline even after controlling for the atrophy scores. Moreover, significant synergistic interactions were found between WML and atrophy measures in overall cognitive performance across time and the rate of cognitive decline. Synergistic effects were also observed between baseline lacunar infarcts and all atrophy measures on change in psychomotor speed. The main results remained robust after exclusion of subjects with clinical stroke or incident dementia, and after additional adjustments for progression of WML and lacunes. Conclusions: Brain atrophy and WML are independently related to longitudinal cognitive decline in small vessel disease. MTA, subcortical, and cortical atrophy seem to potentiate the effect of WML and lacunes on cognitive decline.

Cumulative Effect of Psychosocial Factors in Youth on Ideal Cardiovascular Health in Adulthood The Cardiovascular Risk in Young Finns Study

Background— The American Heart Association has defined a new metric of ideal cardiovascular health as part of its 2020 Impact Goals. We examined whether psychosocial factors in youth predict ideal cardiovascular health in adulthood. Methods and Results— Participants were 477 men and 612 women from the nationwide Cardiovascular Risk in Young Finns Study. Psychosocial factors were measured from cohorts 3 to 18 years of age at the baseline of the study, and ideal cardiovascular health was examined 27 years later in adulthood. The summary measure of psychosocial factors in youth comprised socioeconomic factors, emotional factors, parental health behaviors, stressful events, self-regulation of the child, and social adjustment of the child. There was a positive association between a higher number of favorable psychosocial factors in youth and greater ideal cardiovascular health index in adulthood (&bgr;=0.16; P<0.001) that persisted after adjustment for age, sex, medication use, and cardiovascular risk factors in childhood (&bgr;=0.15; P<0.001). The association was monotonic, suggesting that each increment in favorable psychosocial factors was associated with improvement in cardiovascular health. Of the specific psychosocial factors, a favorable socioeconomic environment (&bgr;=0.12; P<0.001) and participants’ self-regulatory behavior (&bgr;=0.07; P=0.004) were the strongest predictors of ideal cardiovascular health in adulthood. Conclusions— The findings suggest a dose-response association between favorable psychosocial factors in youth and cardiovascular health in adulthood, as defined by the American Heart Association metrics. The effect seems to persist throughout the range of cardiovascular health, potentially shifting the population distribution of cardiovascular health rather than simply having effects in a high-risk population.

Ontological confusions but not mentalizing abilities predict religious belief, paranormal belief, and belief in supernatural purpose

The current research tested the hypothesis that the abilities for understanding other peoples minds give rise to the cognitive biases that underlie supernatural beliefs. We used structural equation modeling (N=2789) to determine the roles of various mentalizing tendencies, namely self-reported affective and cognitive empathy (i.e., mind reading), actual cognitive and affective empathic abilities, hyper-empathizing, and two cognitive biases (core ontological confusions and promiscuous teleology) in giving rise to supernatural beliefs. Support for a path from mentalizing abilities through cognitive biases to supernatural beliefs was weak. The relationships of mentalizing abilities with supernatural beliefs were also weak, and these relationships were not substantially mediated by cognitive biases. Core ontological confusions emerged as the best predictor, while promiscuous teleology predicted only a small proportion of variance. The results were similar for religious beliefs, paranormal beliefs, and for belief in supernatural purpose.

The perception of prosody and associated auditory cues in early-implanted children: The role of auditory working memory and musical activities

Abstract Objective: To study prosodic perception in early-implanted children in relation to auditory discrimination, auditory working memory, and exposure to music. Design: Word and sentence stress perception, discrimination of fundamental frequency (F0), intensity and duration, and forward digit span were measured twice over approximately 16 months. Musical activities were assessed by questionnaire. Study sample: Twenty-one early-implanted and age-matched normal-hearing (NH) children (4–13 years). Results: Children with cochlear implants (CIs) exposed to music performed better than others in stress perception and F0 discrimination. Only this subgroup of implanted children improved with age in word stress perception, intensity discrimination, and improved over time in digit span. Prosodic perception, F0 discrimination and forward digit span in implanted children exposed to music was equivalent to the NH group, but other implanted children performed more poorly. For children with CIs, word stress perception was linked to digit span and intensity discrimination: sentence stress perception was additionally linked to F0 discrimination. Conclusions: Prosodic perception in children with CIs is linked to auditory working memory and aspects of auditory discrimination. Engagement in music was linked to better performance across a range of measures, suggesting that music is a valuable tool in the rehabilitation of implanted children.

Fast Measurement of Auditory Event-Related Potential Profiles in 2–3-Year-Olds

Auditory discrimination, memory, and attention-related functions were investigated in healthy 2–3-year-olds by recording event-related potentials (ERPs) to changes in five auditory features and two types of novel sounds using the fast multifeature paradigm (MFP). ERP profiles consisting of the mismatch negativity (MMN), P3a, and prominent late discriminative negativities (LDN) were obtained, for the first time, from this age group in a considerably shorter time compared to the traditional paradigms. Statistically significant responses from individual children were obtained mainly for the novel sounds. Thus, the MFP shows promise as a time-efficient paradigm for investigating central auditory functions in toddlers.

Cortical processing of musical sounds in children with Cochlear Implants

OBJECTIVE We studied the neurocognitive mechanisms of musical instrument sound perception in children with Cochlear Implants (CIs) and in children with normal hearing (NH). METHODS ERPs were recorded in a new multi-feature change-detection paradigm. Three magnitudes of change in fundamental frequency, musical instrument, duration, intensity increments and decrements, and presence of a temporal gap were presented amongst repeating 295 Hz piano tones. Independent Component Analysis was utilized to remove artifacts caused by the Cochlear Implants. RESULTS The ERPs were similar in the two groups across all perceptual dimensions except for intensity increment deviants. CI children had smaller and earlier P1 responses compared to controls, and their MMN responses showed less accurate neural detection of changes of musical instrument, sound duration, and temporal structure. P3a responses suggested that poor neural detection of musical instruments affected their involuntary attention shift. CONCLUSIONS The similarities of neurocognitive processing are surprising in the light of the limited auditory input provided by the CI, suggesting that many types of changes are adequately processed by the CI children. SIGNIFICANCE Our results indicate that CI childrens auditory cortical functioning may be enhanced, and difficulties in auditory perception and in attention switching towards sound events alleviated, by multisensory musical activities.

The Effect of Personality on Daily Life Emotional Processes

Personality features are associated with individual differences in daily emotional life, such as negative and positive affectivity, affect variability and affect reactivity. The existing literature is somewhat mixed and inconclusive about the nature of these associations. The aim of this study was to shed light on what personality features represent in daily life by investigating the effect of the Five Factor traits on different daily emotional processes using an ecologically valid method. The Experience Sampling Method was used to collect repeated reports of daily affect and experiences from 104 healthy university students during one week of their normal lives. Personality traits of the Five Factor model were assessed using NEO Five Factor Inventory. Hierarchical linear modeling was used to analyze the effect of the personality traits on daily emotional processes. Neuroticism predicted higher negative and lower positive affect, higher affect variability, more negative subjective evaluations of daily incidents, and higher reactivity to stressors. Conscientiousness, by contrast, predicted lower average level, variability, and reactivity of negative affect. Agreeableness was associated with higher positive and lower negative affect, lower variability of sadness, and more positive subjective evaluations of daily incidents. Extraversion predicted higher positive affect and more positive subjective evaluations of daily activities. Openness had no effect on average level of affect, but predicted higher reactivity to daily stressors. The results show that the personality features independently predict different aspects of daily emotional processes. Neuroticism was associated with all of the processes. Identifying these processes can help us to better understand individual differences in daily emotional life.

Internet-based CBT intervention for gamblers in Finland: experiences from the field.

From September 2007 to May 2011 a total of 471 participants (325 males and 146 females) signed up for an 8-week Internet-based cognitive behavioral therapy offered for gamblers in Finland. Sixty-four percent of the participants were pathological gamblers (PGs) (NODS 5> points), 14% were problem gamblers (NODS 3-4 points) and 10% were at risk of gambling problems (NODS 1-2 points). Two hundred and twenty four participants completed the treatment and after the treatment period significant changes were found in the following variables: gambling related problems (NODS), gambling urge, impaired control of gambling, alcohol consumption (AUDIT-C), social consequences, gambling-related cognitive erroneous thoughts and depression (MARD-S). In this sample co-morbid alcohol consumption was stronger among males. The main finding of this study was that the onset age of gambling was associated with a greater amount of gambling-related cognitive erroneous thoughts.

Interplay between singing and cortical processing of music: a longitudinal study in children with cochlear implants.

Informal music activities such as singing may lead to augmented auditory perception and attention. In order to study the accuracy and development of music-related sound change detection in children with cochlear implants (CIs) and normal hearing (NH) aged 4–13 years, we recorded their auditory event-related potentials twice (at T1 and T2, 14–17 months apart). We compared their MMN (preattentive discrimination) and P3a (attention toward salient sounds) to changes in piano tone pitch, timbre, duration, and gaps. Of particular interest was to determine whether singing can facilitate auditory perception and attention of CI children. It was found that, compared to the NH group, the CI group had smaller and later timbre P3a and later pitch P3a, implying degraded discrimination and attention shift. Duration MMN became larger from T1 to T2 only in the NH group. The development of response patterns for duration and gap changes were not similar in the CI and NH groups. Importantly, CI singers had enhanced or rapidly developing P3a or P3a-like responses over all change types. In contrast, CI non-singers had rapidly enlarging pitch MMN without enlargement of P3a, and their timbre P3a became smaller and later over time. These novel results show interplay between MMN, P3a, brain development, cochlear implantation, and singing. They imply an augmented development of neural networks for attention and more accurate neural discrimination associated with singing. In future studies, differential development of P3a between CI and NH children should be taken into account in comparisons of these groups. Moreover, further studies are needed to assess whether singing enhances auditory perception and attention of children with CIs.

Reciprocity of trust in the supervisor–subordinate relationship: The mediating role of autonomy and the sense of power

This article develops and tests a model of reciprocal trust between supervisor and subordinate. Drawing from literature on trust and control and on the approach/inhibition theory of power, the authors present a model in which supervisor trust is suggested to enhance subordinate reciprocal trust through increased work-related autonomy and a heightened sense of power. The mediator analysis using the two-level full structural model confirmed that the relationship between supervisor trust and subordinate trust was partially mediated by the suggested chain of variables. The article responds to a call for empirical studies on reciprocal trust and offers a complementary mechanism for trust building beside characteristics and relationship-based approaches.