Jason A. Croskrey

Directional optical coherence tomography provides accurate outer nuclear layer and Henle fiber layer measurements

Purpose: The outer nuclear layer (ONL) contains photoreceptor nuclei, and its thickness is an important biomarker for retinal degenerations. Accurate ONL thickness measurements are obscured in standard optical coherence tomography (OCT) images because of Henle fiber layer (HFL). Improved differentiation of the ONL and HFL boundary is made possible by using directional OCT, a method that purposefully varies the pupil entrance position of the OCT beam. Methods: Fifty-seven normal eyes were imaged using multiple pupil entry positions with a commercial spectral domain OCT system. Cross-sectional image sets were registered to each other and segmented at the top of HFL, the border of HFL and the ONL and at the external limiting membrane. Thicknesses of the ONL and HFL were measured and analyzed. Results: The true ONL and HFL thicknesses varied substantially by eccentricity and between individuals. The true macular ONL thickness comprised an average of 54.6% of measurements that also included HFL. The ONL and HFL thicknesses at specific retinal eccentricities were poorly correlated. Conclusion: Accurate ONL and HFL thickness measurements are made possible by the optical contrast of directional OCT. Distinguishing these individual layers can improve clinical trial endpoints and assessment of disease progression.

Adaptive Optics and SD-OCT Imaging of Human Photoreceptor Structure After Short Duration (20 ms) Pascal™ Macular Grid and Panretinal Laser Photocoagulation

To the Editor: To understand the effect of therapeutic doses of laser application on the neurosensory retina, detailed histologic1-3 and optical coherence tomographic4-10 evaluations have been employed in both animal models and in the human eye. We sought to evaluate photoreceptor structure associated with laser photocoagulation lesions using two high-resolution retinal imaging tools (adaptive optics (AO) and SD-OCT).

Adaptive optics and spectral- domain optical coherence tomography of human photoreceptor structure after short-duration [corrected] pascal macular grid and panretinal laser photocoagulation.

To the Editor: To understand the effect of therapeutic doses of laser application on the neurosensory retina, detailed histologic1-3 and optical coherence tomographic4-10 evaluations have been employed in both animal models and in the human eye. We sought to evaluate photoreceptor structure associated with laser photocoagulation lesions using two high-resolution retinal imaging tools (adaptive optics (AO) and SD-OCT).

Retinal Complications Associated With Pars Plana Vitrectomy for Macular Holes or Epiretinal Membranes in Eyes With Previous Retinal Detachment Repair

Retinal Complications Associated With Pars Plana Vitrectomy for Macular Holes or Epiretinal Membranes in Eyes With Previous Retinal Detachment Repair Pars plana vitrectomy (PPV) is associated with risk of intraoperative retinal tears (RTs) and postoperative rhegmatogenous retinal detachment (RRD). Eyes undergoing RRD repair are at higher risk for developing subsequent epiretinal membranes (ERMs) that may compromise vision.1,2 For cannulated surgery as compared with standard 20-gauge PPV, we previously reported markedly lower of risk of intraoperative RT (3.3% vs 23.0%, respectively) and a trend toward reduced risk of postoperative RD (2.8% vs 5.9%, respectively).3 However, in eyes with previous RRD repair, risks of these events are not well documented. Therefore, we evaluated eyes with previous RRD repair undergoing PPV for ERMs or macular holes (MHs) and compared them with eyes without prior RRD.

Adaptive Optics and Spectral-Domain Optical Coherence Tomography of Human Photoreceptor Structure After Short Pascal Macular Grid and Panretinal Laser Photocoagulation

To the Editor: To understand the effect of therapeutic doses of laser application on the neurosensory retina, detailed histologic1-3 and optical coherence tomographic4-10 evaluations have been employed in both animal models and in the human eye. We sought to evaluate photoreceptor structure associated with laser photocoagulation lesions using two high-resolution retinal imaging tools (adaptive optics (AO) and SD-OCT).

Adverse reactions to plain gut, polyglycolic Acid, and polyglactin 910 sutures for sclerotomy closure at pars plana vitrectomy.

PURPOSE To evaluate the rates of adverse reactions to suture materials and compare the rates for plain gut, polyglycolic acid, and polyglactin 910. METHODS Postoperative adverse suture reaction rates were compared using Fisher exact test. One hundred and forty-six patients who underwent pars plana vitrectomy were included in this study. RESULTS Adverse suture reaction rates were 2% (1/48) for plain gut, 30% (6/20) for polyglycolic acid, and 12% (11/78) for polyglactin 910. CONCLUSION Plain gut suture was associated with fewer adverse suture reactions when compared with polyglycolic acid and polyglactin 910 and seems to be suitable for sclerotomy closure.