Jason D. Christie
Hospital of the University of Pennsylvania
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Featured researches published by Jason D. Christie.
Chest | 2005
Mary Elizabeth Kreider; Jason D. Christie; Bruce Thompson; Lee S. Newman; Cecile S. Rose; Juliana Barnard; Eddy A. Bresnitz; Marc A. Judson; Daniel T. Lackland; Milton D. Rossman
STUDY OBJECTIVESnSarcoidosis is a granulomatous disorder with heterogeneous clinical manifestations, which are potentially reflective of a syndrome with different etiologies leading to similar histologic findings. We examined the relationship between environmental and occupational exposures, and the clinical phenotype of sarcoidosis.nnnDESIGNnWe performed a cross-sectional study of incident sarcoidosis cases that had been identified by A Case Control Etiologic Study of Sarcoidosis. Subjects were categorized into the following two groups: (1) pulmonary-only disease; and (2) systemic disease (with or without pulmonary involvement). Logistic regression was used to examine the associations of candidate exposures with clinical phenotype.nnnSETTINGnTen academic medical centers across the United States.nnnPATIENTSnThe current study included 718 subjects in whom sarcoidosis had been diagnosed within 6 months of study enrollment. Patients met the following criteria prior to enrollment: (1) tissue confirmation of noncaseating granulomas on tissue biopsy on one or more organs within 6 months of study enrollment with negative stains for acid-fast bacilli and fungus; (2) clinical signs or symptoms that were consistent with sarcoidosis; (3) no other obvious explanation for the granulomatous disease; and (4) age > 18 years.nnnMEASUREMENTS AND RESULTSnSeveral exposures were associated with significantly less likelihood of having extrapulmonary disease in multivariate analysis, including agricultural organic dusts and wood burning. The effects of many of these exposures were significantly different in patients of different self-defined race.nnnCONCLUSIONSnThe differentiation of sarcoidosis subjects on the basis of clinical phenotypes suggests that these subgroups may have unique environmental exposure associations. Self-defined race may play a role in the determination of the effect of certain exposures on disease phenotypes.
Chest | 2007
Giora Netzer; Chirag V. Shah; Theodore J. Iwashyna; Paul N. Lanken; Barbara Finkel; Barry D. Fuchs; Wensheng Guo; Jason D. Christie
Journal of Heart and Lung Transplantation | 2006
Yongping Wang; Jibby E. Kurichi; Nancy P. Blumenthal; V. Ahya; Jason D. Christie; Alberto Pochettino; Larry R. Kaiser; Seema S. Sonnad; Eleanor S. Pollak
Respiratory Care | 2006
Adam Gilden Tsai; Jason D. Christie; Christina A Gaughan; Wenceslao R Palma; Mitchell L. Margolis
Archive | 2008
Jason D. Christie; Shwu-Fan Ma; Richard Aplenc; Mingyao Li; Paul N. Lanken; Chirag V. Shah; Barry D. Fuchs; Steven M. Albelda; Carlos Flores; Joe G. N. Garcia
Respiratory Care | 2006
Christopher W. Seymour; Jason D. Christie; Christina Gaughan; Barry D. Fuchs
Respiratory Care | 2005
Christopher W. Seymour; Jason D. Christie; Christina Gaughan; Barry D. Fuchs
Journal of Heart and Lung Transplantation | 2014
J.M. Dolan; C.W. Compher; David J. Lederer; Nancy P. Blumenthal; Jason D. Christie; R.J. Shah
Chest | 2008
Giora Netzer; Chirag V. Shah; Theodore J. Iwashyna; Paul N. Lanken; Barbara Finkel; Barry D. Fuchs; Jason D. Christie; Wensheng Guo
Archive | 2007
Barbara Finkel; Barry D. Fuchs; Wensheng Guo; Jason D. Christie; Giora Netzer; Chirag V. Shah; Theodore J. Iwashyna; Paul N. Lanken