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Dive into the research topics where Jason R. Chan is active.

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Featured researches published by Jason R. Chan.


Nature Immunology | 2007

Development, cytokine profile and function of human interleukin 17-producing helper T cells

Nicholas J Wilson; Katia Boniface; Jason R. Chan; Brent S. McKenzie; Wendy M. Blumenschein; Jeanine D. Mattson; Beth Basham; Kathleen Smith; Taiying Chen; Franck Morel; Jean-Claude Lecron; Robert A. Kastelein; Daniel J. Cua; Terrill K. McClanahan; Edward P. Bowman; Rene de Waal Malefyt

TH-17 cells are a distinct lineage of proinflammatory T helper cells that are essential for autoimmune disease. In mice, commitment to the TH-17 lineage is dependent on transforming growth factor-β and interleukin 6 (IL-6). Here we demonstrate that IL-23 and IL-1β induced the development of human TH-17 cells expressing IL-17A, IL-17F, IL-22, IL-26, interferon-γ, the chemokine CCL20 and transcription factor RORγt. In situ, TH-17 cells were identified by expression of the IL-23 receptor and the memory T cell marker CD45RO. Psoriatic skin lesions contained IL-23-producing dendritic cells and were enriched in the cytokines produced by human TH-17 cells that promote the production of antimicrobial peptides in human keratinocytes. Our data collectively indicate that human and mouse TH-17 cells require distinct factors during differentiation and that human TH-17 cells may regulate innate immunity in epithelial cells.


Journal of Experimental Medicine | 2006

IL-23 stimulates epidermal hyperplasia via TNF and IL-20R2–dependent mechanisms with implications for psoriasis pathogenesis

Jason R. Chan; Wendy M. Blumenschein; Erin Murphy; Caroline Diveu; Maria T. Wiekowski; Susan J. Abbondanzo; Linda Lucian; Richard Geissler; Scott J. Brodie; Alexa B. Kimball; Daniel M. Gorman; Kathleen Smith; Rene de Waal Malefyt; Robert A. Kastelein; Terrill K. McClanahan; Edward P. Bowman


Archive | 2003

Methods of treating wounds using IL-23

Edward P. Bowman; Shi-Juan Chen; Daniel J. Cua; Jason R. Chan


Archive | 2008

Use of cytokine expression to predict skin inflammation; methods of treatment

Robert A. Kastelein; Terrill K. McClanahan; Erin Murphy; Jason R. Chan


Archive | 2006

Method of evaluating inflammatory skin disorders using IL-17 and/or IL-19

Robert A. Kastelein; Terrill K. McClanahan; Erin Murphy; Jason R. Chan


Archive | 2008

Methods of treating cutaneous ulcers and grafts using IL-23

Edward P. Bowman; Shi-Juan Chen; Daniel J. Cua; Jason R. Chan


Archive | 2009

Agonist antibodies to IL-23 receptor

Edward P. Bowman; Shi-Juan Chen; Daniel J. Cua; Kevin W. Moore; Tatyana Churakova; Hong-Nhung Y. Nguyen; Jason R. Chan


Archive | 2008

Method of treatment of skin inflammation

Robert A. Kastelein; Terrill K. McClanahan; Erin Murphy; Jason R. Chan


Archive | 2011

Methods of treating cutaneous ulcers and grafts using agonist antibodies to IL-23 receptor

Edward P. Bowman; Shi-Juan Chen; Daniel J. Cua; Kevin W. Moore; Tatyana Churakova; Hong-Nhung Y. Nguyen; Jason R. Chan


Archive | 2003

Uses of il-23 mammalian cytokine; related reagents

Edward P. Bowman; Shi-Juan Chen; Daniel J. Cua; Kevin W. Moore; Tatyana Churakova; Hong-Nhung Y. Nguyen; Jason R. Chan

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