Javaregowda S. Prasad

Synthesis and X-ray structure conformation of novel unsymmetrical 1,4-dihydropyridine

Methyl 2,6-dimethyl-5-(2-methylphenylcarbamoyl)-4-(3-nitrophenyl)-1,4-dihydropyridine-2-carboxylate (3) was prepared by known Hantzch method and its structure was elucidated by X-ray diffraction method.

Synthesis and crystal structure studies of (2RS)-3-[(2RS)-2-(1-hydroxy-cyclohexyl)-2-(4-methoxyphenyl)ethyl]-2-(pyridin-3-yl)thiazolidin-4-one

The compound (2RS)-3-[(2RS)-2-(1-hydroxycyclohexyl)-2-(4-methoxyphenyl)ethyl]-2-(pyridin-3-yl)-thiazolidin-4-one 4 was synthesised via one-pot three-component system in three different methods, such as conventional (DCC), MW irradiation with solvent and MW irradiation without solvent methods. Among them, MW irradiation without solvent has the advantage of short time with high yield and environmentally benign. The synthesised compound was characterised by spectroscopic technique and finally confirmed by X-ray diffraction. The compound crystallises in the triclinic crystal system with Z = 2 in the space group P1. The cell parametres are a = 10.317(9) Å, b = 10.280(1) Å, c = 11.408(6) Å, α = 73.824(6)° β = 70.122(5)° γ = 70.293(3)° and R1 = 0.0527 for 10124 reflections [I>2σ(I)]. The cyclohexane ring of the molecule is in chair conformation. The molecule exhibits intermolecular hydrogen bonds of type N–H…O and C–H…O.

Synthesis and crystal structure of 1-ethyl-3-(phenyl)-1,2,3-triazolium percholorate

The isolation of stable carbenes of the Arduengo (1a) and Wanzlick (2a) type has prompted us to look for stable nitrenium ions of the related structural type 1-ethyl-3-(phenyl)-1,2,3-triazolium perchlorate (6+). The title compound C10H14Cl N3O4 was isolated and structure was investigated by X-ray crystallography. It crystallizes in the monoclinic space group P21/c with cell parameters a=6.697(4) Å, b=9.724(9) Å, c=19.844(2) Å and Z=4. The final residual factor is R1=0.0471 for 1545 reflections with I>2σ(I). The structure exhibits intermolecular hydrogen bonds.