Javier Korta

Young Infants with Recurrent Wheezing and Positive Asthma Predictive Index Have Higher Levels of Exhaled Nitric Oxide

Objective. The aim of this post hoc analysis was to establish the relationship between FENO levels and the asthma predictive index (API) among infants with recurrent wheezing. Methods. Infants with recurrent wheezing (three or more episodes) were recruited consecutively and online FENO tests at tidal breathing with multiple breaths were performed. Results. Twenty-seven (84%) out of 32 infants (median age of 12 months) who met the inclusion criteria for this post hoc analysis, successfully performed the FENO determinations. Eighteen (66%) infants were classified with positive stringent API. FENO levels were significantly higher among patients with positive API than those with negative (median [IQR] of 12.3 [14.8] ppb vs. 4.1 [7.9] ppb, respectively, p = .016). Furthermore, FENO and positive API had a significant correlation (Spearman’s rho, ρ = 0.4741, p = .0125). After logistic regression analysis including FENO levels, gender, age, and use of controller therapy, FENO was the only variable that was marginally related to API (OR = 1.12, 95% CI: 0.99–1.27, p = .07). Conclusion. Infants with recurrent wheezing who had a positive stringent API already had higher FENO levels than those with a negative API. This finding needs to be corroborated in a larger prospective study.

Concordancia en niños entre las resistencias de la vía aérea medidas mediante pletismografía con y sin cierre del oclusor

BACKGROUND There have been several studies that have measured airway resistances using plethysmography without closing the occluder. OBJECTIVE To investigate the differences between the total resistances (sRaw(TOT)) and the specific resistances (sRaw) with the same technique (plethysmography) but different methodology (with and without closure of the occluder) in child subjects. MATERIAL AND METHODS An observational and cross-sectional study of a consecutive sample of children between 6 and 14 years old who were seen at the Childhood Pneumology clinics from 15th January to 15th February 2009. Determination of sRaw(TOT), sRaw and specific conductance (sGaw) using plethysmography (MasterLab V5.1, Viasys, Wuerzburg, Germany) without closing the occluder. The same determinations were then performed with the occluder closed. The qualitative variables were: sex, diagnosis and treatment, and the quantitative variables: age, weight, height, sRaw(TOT), sRaw, sGaw and respiratory rate with and without closing the occluder. The results were analysed for association and concordance between sRaw(TOT), sRaw and sGaw with and without closure of the occluder using paired Student t test, Bland-Altman method and a scatter plot. RESULTS Thirty-six cases were included and all (100%) the tests were performed successfully. The mean age was 9.91+/-2.37 years. There were no differences between sRawTOT, sRaw or sGaw with and without closure of the occluder. Neither were there any differences between the regression of the means obtained for sRaw(TOT), sRaw and sGaw with and without closure of the occluder. CONCLUSIONS There is good agreement between the sRaw(TOT) y sRaw obtained by plethysmography with and without closure of the occluder.

Differences in Airway Resistances in Children Measured by Plethysmography With and Without Closure of the Occluder

Abstract Background There have been several studies that have measured airway resistances using plethysmography without closing the occluder Objective To investigate the differences between the total resistances (sRawTOT) and the specific resistances (sRaw) with the same technique (plethysmography) but different methodology (with and without closure of the occluder) in child subjects. Material and methods An observational and cross-sectional study of a consecutive sample of children between 6 and 14 years old who were seen at the Childhood Pneumology clinics from 15th January to 15th February 2009. Determination of sRawTOT, sRaw and specific conductance (sGaw) using plethysmography (MasterLab V5.1, Viasys®, Wuerzburg, Germany) without closing the occluder. The same determinations were then performed with the occluder closed. The qualitative variables were: sex, diagnosis and treatment, and the quantitative variables: age, weight, height, sRawTOT, sRaw, sGaw and respiratory rate with and without closing the occluder. The results were analysed for association and concordance between sRawTOT, sRaw and sGaw with and without closure of the occluder using paired Student t test, Bland-Altman method and a scatter plot. Results Thirty-six cases were included and all (100%) the tests were performed successfully. The mean age was 9.91±2.37 years. There were no differences between sRawTOT, sRaw or sGaw with and without closure of the occluder. Neither were there any differences between the regression of the means obtained for sRawTOT, sRaw and sGaw with and without closure of the occluder. Conclusions There is good agreement between the sRawTOT y sRaw obtained by plethysmography with and without closure of the occluder.

Alveolar nitric oxide contribution to assess asthma control

A03-17 Alveolar nitric oxide contribution to assess asthma control O. Sardon, P. Corcuera, A. Aldasoro, J. Korta, J. Mintegui, J.I. Emparanza, E.G. Perez Yarza. 1 Department of Pediatrics, Division of Respiratory Medicine, University Hospital Donostia; Medical School (U.D. San Sebastian), University of the Basque Country, Department of Pediatrics, San Sebastian, Spain; Department of Pediatrics, Division of Respiratory Medicine, University Hospital Donostia, San Sebastian, Spain; University Donostia Hospital Epidemiology Unit (CIBER-ESP), San Sebastian, Spain