Jayanta Samanta
Post Graduate Institute of Medical Education and Research
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Publication
Featured researches published by Jayanta Samanta.
World Journal of Gastrointestinal Endoscopy | 2015
Jayanta Samanta; Narendra Dhaka; Saroj K. Sinha; Rakesh Kochhar
Benign esophageal strictures refractory to the conventional balloon or bougie dilatation may be subjected to various adjunctive modes of therapy, one of them being endoscopic incisional therapy (EIT). A proper delineation of the stricture anatomy is a prerequisite. A host of electrocautery and mechanical devices may be used, the most common being the use of needle knife, either standard or insulated tip. The technique entails radial incision and cutting off of the stenotic rim. Adjunctive therapies, to prevent re-stenosis, such as balloon dilatation, oral or intralesional steroids or argon plasma coagulation can be used. The common strictures where EIT has been successfully used are Schatzkis rings (SR) and anastomotic strictures (AS). Short segment strictures (< 1 cm) have been found to have the best outcome. When compared with routine balloon dilatation, EIT has equivalent results in treatment naïve cases but better long term outcome in refractory cases. Anecdotal reports of its use in other types of strictures have been noted. Post procedure complications of EIT are mild and comparable to dilatation therapy. As of the current evidence, incisional therapy can be used for management of refractory AS and SR with relatively short stenosis (< 1 cm) with good safety profile and acceptable long term patency.
World Journal of Gastroenterology | 2015
Narendra Dhaka; Jayanta Samanta; Suman Kochhar; Navin Kalra; Sreekanth Appasani; Manish Manrai; Rakesh Kochhar
Pancreatic fluid collections (PFCs) are seen in up to 50% of cases of acute pancreatitis. The Revised Atlanta classification categorized these collections on the basis of duration of disease and contents, whether liquid alone or a mixture of fluid and necrotic debris. Management of these different types of collections differs because of the variable quantity of debris; while patients with pseudocysts can be drained by straight-forward stent placement, walled-off necrosis requires multi-disciplinary approach. Differentiating these collections on the basis of clinical severity alone is not reliable, so imaging is primarily performed. Contrast-enhanced computed tomography is the commonly used modality for the diagnosis and assessment of proportion of solid contents in PFCs; however with certain limitations such as use of iodinated contrast material especially in renal failure patients and radiation exposure. Magnetic resonance imaging (MRI) performs better than computed tomography (CT) in characterization of pancreatic/peripancreatic fluid collections especially for quantification of solid debris and fat necrosis (seen as fat density globules), and is an alternative in those situations where CT is contraindicated. Also magnetic resonance cholangiopancreatography is highly sensitive for detecting pancreatic duct disruption and choledocholithiasis. Endoscopic ultrasound is an evolving technique with higher reproducibility for fluid-to-debris component estimation with the added advantage of being a single stage procedure for both diagnosis (solid debris delineation) and management (drainage of collection) in the same sitting. Recently role of diffusion weighted MRI and positron emission tomography/CT with (18)F-FDG labeled autologous leukocytes is also emerging for detection of infection noninvasively. Comparative studies between these imaging modalities are still limited. However we look forward to a time when this gap in literature will be fulfilled.
World Journal of Gastroenterology | 2018
Chetana Vaishnavi; Jayanta Samanta; Rakesh Kochhar
AIM To quantify the components in biofilms and analyze the predisposing factors involved in occlusion of biliary stents. METHODS In a prospective study conducted from April 2011 to March 2014 at a tertiary care hospital, all consecutive patients who required endoscopic biliary stent exchange/removal were included. Etiology of the biliary disease was diagnosed by imaging, cytology and on follow-up. Clinical details of patients with biliary stent retrieval were noted. All extracted stents were collected in sterile containers and immediately processed for quantification of biofilm proteins and polysaccharides. Molecular identification of commonly known and unknown bacteria was performed by polymerase chain reaction and density gradient gel electrophoresis methods. RESULTS Eighty one patients (41 males) with age range of 20-86 years were studied. The underlying causes for stent insertion were bile duct stones (n = 46; 56.8%) benign stricture (n = 29; 35.8%) and malignancy (n = 6; 7.4%) with cholangitis in 50 (61.7%) patients. The retrieved stent sizes were 7 Fr (n = 62; 76.5%) and 10 Fr (n = 19; 23.5%) with 65 days median insertion duration. Polybacterial consortia were detected in 90.1% of the stents. The most common bacteria identified by polymerase chain reaction alone and/or sequencing were Pseudomonas (n = 38), Citrobacter (n = 23), Klebsiella (n = 22), Staphylococcus (n = 20), Serratia (n = 16), Escherichia coli (n = 14), Streptococcus (n = 13), Enterococcus (n = 13), Aeromonas (n = 12), Proteus (n = 10) and Enterobacter (n = 9). Protein concentration according to gender (0.547 ± 0.242 mg/mL vs 0.458 ± 0.259 mg/mL; P = 0.115) as well as age > 60 years and < 60 years (0.468 ± 0.295 mg/mL vs 0.386 ± 0.238 mg/mL; P = 0.205) was non-significant. However, polysaccharide concentration was significant both according to gender (0.052 ± 0.021 mg/mL vs 0.049 ± 0.016 mg/mL; P < 0.0001) and age (0.051 ± 0.026 mg/mL vs 0.038 ± 0.016 mg/mL; P < 0.011). Protein concentration in the biofilm was significantly higher (0.555 ± 0.225 mg/mL vs 0.419 ± 0.276 mg/mL; P = 0.018) in patients with cholangitis, lower (0.356 ± 0.252 mg/mL vs 0.541 ± 0.238 mg/mL; P = 0.005) in the 10 Fr group than the 7 Fr group, and significantly higher (0.609 ± 0.240 mg/mL vs 0.476 ± 0.251 mg/mL; P = 0.060) in stents of ≥ 6 mo of indwelling time. However presence/absence of cholangitis, size of stent, indication of stent insertion and indwelling time did not affect the quantity of polysaccharide concentration. CONCLUSION Plastic stents retrieved from patients with biliary tract disease showed polymicrobial organisms with higher protein content among patients with cholangitis and those with smaller diameter stents. Longer indwelling duration had more biofilm formation.
Journal of Gastroenterology and Hepatology | 2018
Narendra Dhaka; Saroj K. Sinha; Jayanta Samanta; Vikas Gupta; Thakur Deen Yadav; Ajay S. Gulati; Rakesh Kochhar
To compare the clinical outcome of patients with extrapancreatic necrosis (EXPN) alone with that of acute interstitial pancreatitis (AIP), pancreatic parenchymal necrosis (PPN) alone, and combined PPN and EXPN.
Pancreatology | 2018
Jayanta Samanta; Sukhwinder Singh; Sunil K. Arora; Gaurav Muktesh; Ashutosh N. Aggarwal; Narendra Dhaka; Saroj K. Sinha; Vikas Gupta; Vishal Sharma; Rakesh Kochhar
International Journal of Gynecological Pathology | 2018
Gaurav Muktesh; Suvradeep Mitra; Saroj K. Sinha; Narendra Dhaka; Uma Nahar Saikia; Phulen Sarma; Ajay S. Gulati; Jayanta Samanta; Rakesh Kochhar
Digestive Diseases and Sciences | 2018
Neha Berry; Saroj K. Sinha; Anish Bhattacharya; KaushalK Prasad; Chetana Vaishnavi; Kim Vaiphei; Jayanta Samanta; Raghavendra Prasada; Narendra Dhaka; Rakesh Kochhar
Gastroenterology | 2017
Neha Berry; Saroj K. Sinha; Rakesh Kochhar; Narendra Dhaka; Jayanta Samanta; Raghavendra Prasad; Chetana Vaishnavi; Kim Vaiphei; Anish Bhattacharya; Kaushal Kishor Prasad
Gastroenterology | 2017
Narendra Dhaka; Rakesh Kochhar; Saroj K. Sinha; Jayanta Samanta; Raghavendra Prasad; Neha Berry; Vikas Gupta; Thakur Deen Yadav
Gastroenterology | 2017
Rakesh Kochhar; Narendra Dhaka; Saroj K. Sinha; Jayanta Samanta; Raghavendra Prasad; Neha Berry; Vikas Gupta; Thakur Deen Yadav
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View shared research outputsPost Graduate Institute of Medical Education and Research
View shared research outputsPost Graduate Institute of Medical Education and Research
View shared research outputsPost Graduate Institute of Medical Education and Research
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