Network


Latest external collaboration on country level. Dive into details by clicking on the dots.

Hotspot


Dive into the research topics where Je Ho Ryu is active.

Publication


Featured researches published by Je Ho Ryu.


Journal of the Korean Crystal Growth and Crystal Technology | 2012

CFD analysis for effects of the crucible geometry on melt convection and growth behavior during sapphire single crystal growth by Kyropoulos process

Je Ho Ryu; W.J. Lee; Y.C. Lee; H.H. Jo; Y.H. Park

Sapphire single crystals have been highlighted for epitaxial gallium nitride films in high-power laser and light emitting diode (LED) industries. Among the many crystal growth methods, the Kyropoulos process is an excellent commercial method for growing larger, high-optical-quality sapphire crystals with fewer defects. Because the properties and growth behavior of sapphire crystals are influenced largely by the temperature distribution and convection of molten sapphire during the manufacturing process, accurate predictions of the thermal fields and melt flow behavior are essential to design and optimize the Kyropoulos crystal growth process. In this study, computational fluid dynamic simulations were performed to examine the effects of the crucible geometry aspect ratio on melt convection during Kyropoulos sapphire crystal growth. The results through the evolution of various growth parameters on the temperature and velocity fields and convexity of the crystallization interface based on finite volume element simulations show that lower aspect ratio of the crucible geometry can be helpful for the quality of sapphire single crystal.


Transplant Infectious Disease | 2017

Culture-negative fever after pancreas transplantation.

Je Ho Ryu; Tae Beom Lee; Young Mok Park; Kwang Ho Yang; Chong Woo Chu; Jung Hee Lee; Byung Hyun Choi

We read the excellent article by Shin etxa0al.1 entitled “Incidence and differential characteristics of culture-negative fever following pancreas transplantation with anti-thymocyte globulin induction.” It is very interesting and educational. However, one unfortunate thing is that the authors were unable to clearly identify the cause of the fever. We had a similar case to the authors’ case reported in the article. We found that the cause of the fever in our case was isolated graft duodenal rejection without graft pancreatic rejection. n nThis article is protected by copyright. All rights reserved.


Journal of Korean Medical Science | 2017

Clinical Impacts of Donor Types of Living vs. Deceased Donors: Predictors of One-Year Mortality in Patients with Liver Transplantation

Eun-Jung Kim; Seungjin Lim; Chong Woo Chu; Je Ho Ryu; Kwangho Yang; Young Mok Park; Byung Hyun Choi; Tae Beom Lee; Su Jin Lee

Transplantation studies about the clinical differences according to the type of donors are mostly conducted in western countries with rare reports from Asians. The aims of this study were to evaluate the clinical impacts of the type of donor, and the predictors of 1-year mortality in patients who underwent liver transplantation (LT). This study was performed for liver transplant recipients between May 2010 and December 2014 at the Pusan National University Yangsan Hospital. A total of 185 recipients who underwent LT were analyzed. Of the 185 recipients, 109 (58.9%) belonged to the living donor liver transplantation (LDLT) group. The median age was 52.4 years. LDLT recipients had lower model for end-stage liver disease (MELD) score compared with better liver function than deceased donor liver transplantation (DDLT) recipients (mean ± standard deviation [SD], 12.5 ± 8.3 vs. 24.9 ± 11.7, respectively; P < 0.001), and had more advanced hepatocellular carcinoma (HCC) (62.4% vs. 21.1%, respectively; P = 0.001). In complications and clinical outcomes, LDLT recipients showed shorter stay in intensive care unit (ICU) (mean ± SD, 10.8 ± 8.8 vs. 23.0 ± 13.8 days, respectively, P < 0.001), ventilator care days, and post-operative admission days, and lower 1-year mortality (11% vs. 27.6%, respectively, P = 0.004). Bleeding and infectious complications were less in LDLT recipients. Recipients with DDLT (P = 0.004) showed higher mortality in univariate analysis, and multi-logistic regression analysis found higher MELD score and higher pre-operative serum brain natriuretic peptide (BNP) were associated with 1-year mortality. This study may guide improved management before and after LT from donor selection to post-operation follow up.


Annals of Transplantation | 2017

Pancreas Transplant with Duodeno-Duodenostomy and Caval Drainage Using a Diamond Patch Graft: A Single-Center Experience.

Je Ho Ryu; Tae Beom Lee; Young Mok Park; Kwang Ho Yang; Chong Woo Chu; Jung Hee Lee; Tae-Un Kim; Byung Hyun Choi

BACKGROUND The surgical technique used in pancreas transplant is essential for patient safety and graft survival, and problems exist with conventional strategies. When enteric exocrine drainage is performed, there is no method of immunologic monitoring other than direct graft pancreas biopsy. The most common cause of early graft failure is graft thrombosis, and adequate preventive and treatment strategies are unclear. To overcome these disadvantages, we suggest a modified surgical technique. MATERIAL AND METHODS Eleven patients underwent pancreas transplant with our modified technique. The modified surgical techniques are as follows: 1) graft duodenum was anastomosed with recipient duodenum to enable endoscopic immunological monitoring, and 2) the inferior vena cava was chosen for vascular anastomosis and a diamond-shaped patch was applied to prevent graft thrombosis. RESULTS No patient mortality or graft failure occurred. One case of partial thrombosis of the graft portal vein occurred, which did not affect graft condition, and resolved after heparin treatment. All patients were cured from diabetes mellitus. There were no cases of pancreatic rejection, but 2 cases of graft duodenal rejection occurred, which were adequately treated with steroid therapy. CONCLUSIONS This modified surgical technique for pancreas transplant represents a feasible method for preventing thrombosis and allows for direct graft monitoring through endoscopy.


Transplant Immunology | 2018

CMV specific T cell immunity predicts early viremia after liver transplantation

Kyung-Hwa Shin; Hyun-Ji Lee; Chulhun L. Chang; Eun-Jung Kim; Seungjin Lim; Su Jin Lee; Je Ho Ryu; Kwangho Yang; Byung Hyun Choi; Tae Beom Lee; Sun Min Lee

BACKGROUNDnCytomegalovirus (CMV) infection is one of the most important factors affecting liver transplant with direct and indirect effects. However, CMV disease after transplant remains poorly predicted.nnnOBJECTIVEnIn this study, preoperative CMV-specific cell-mediated immunity was evaluated in recipients of liver transplant in Korea, where most people are seropositive.nnnMETHODSnA total of 32 patients were enrolled in a prospective study, and blood samples were collected before liver transplant to determine CMV-specific cell-mediated immunity. Testing using ELiSpot IFN-γ (CMVspot) and CMV serology were performed simultaneously.nnnRESULTSnCMVspot results showed that 30 recipients had CMV-specific cell-mediated immunity, of which 29 were positive for phosphoprotein 65 and 14 for immediate early protein 1 (IE-1). All patients were positive for CMV IgG before transplantation, and 17 patients had a CMV viremia episode after transplantation. CMVspot showed 100% specificity and positive predictive value, and 11.76% sensitivity to predict CMV viremia. Patients with positive or borderline results for IE-1 did not show viremia two months after transplantation (pu202f=u202f.041).nnnCONCLUSIONnCMVspot may be helpful in establishing a treatment strategy that includes regular monitoring for risk stratification of CMV reactivation.


The Korean Journal of Internal Medicine | 2018

Predictors of postoperative infectious complications in liver transplant recipients: experience of 185 consecutive cases

Seungjin Lim; Eun Jung Kim; Tae Beom Lee; Byung Hyun Choi; Young Mok Park; Kwangho Yang; Je Ho Ryu; Chong Woo Chu; Su Jin Lee

Background/Aims Infections following liver transplant (LT) remain a major cause of mortality. This study was conducted to evaluate risk factors for infection and to review clinical characteristics. Methods Medical records of patients who underwent LT from 2010 to 2014 were retrospectively analyzed. Binary logistic regression analysis was used to investigate risk factors of infection. Kaplan-Meier analysis was used to predict prognosis of infected and non-infected groups. Results Of 185 recipients, 89 patients experienced infectious complications. The median follow-up period was 911 days (range, 9 to 2,031). The infected group had higher 1-year mortality (n = 22 [24.7%] vs. n = 8, [8.3%], p = 0.002), and longer postoperative admission days (mean: 53.7 ± 35.8 days vs. 28.3 ± 13.0 days, p < 0.001), compared to the non-infected group. High preoperative Model for End-Stage Liver Disease (MELD) score (odds ratio [OR], 1.057; 95% confidence interval [CI], 1.010 to 1.105; p = 0.016), deceased-donor type (OR, 5.475; 95% CI, 2.442 to 12.279; p < 0.001), and acute rejection (OR, 3.042; 95% CI, 1.241 to 7.454; p = 0.015) were independent risk factors associated with infection. Intra-abdominal infection (n = 35, 20.8%) was the major infectious complication. Among identified bacteria, Enterococcus species (28.4%) were major pathogens, followed by Escherichia coli and Klebsiella species. Conclusions High preoperative MELD score, deceased-donor type, and acute rejection were risk factors associated with infection. To prevent infections following surgery, it is important to determine the appropriate time of operation before the recipient has a high MELD score.


Transfusion and Apheresis Science | 2017

Increasing use of therapeutic apheresis as a liver-saving modality ☆

Hyun-Ji Lee; Kyung-Hwa Shin; Duyeal Song; Sun-Min Lee; Chulhun L. Chang; Chong Woo Chu; Je Ho Ryu; Tae Bum Lee; Yong-Mok Park; Kwang Ho Yang; Byung Hyun Choi; Hyung-Hoi Kim

INTRODUCTIONnTherapeutic plasma exchange (TPE) is used for temporary support of liver function in patients presenting with early graft dysfunction after liver transplantation (LT) or liver surgery. We analyzed the effect of therapeutic apheresis on patients with liver disease.nnnMETHODSnBetween January 2011 and August 2016, 93 apheresis procedures were performed for 26 patients at our institution. Anti-ABO isoagglutination immunoglobulin (Ig) M titer was checked using a type A and type B 3% red blood cell (RBC) suspension in saline with two-fold serial dilutions of patient serum. Anti-ABO isoagglutination IgG titer was checked by a type A and B 0.8% RBC suspension using a low-ionic strength/Coombs card.nnnRESULTSnABO-incompatible (ABOi) LT was the most common (n=10, 38.5%) indication for apheresis; early graft dysfunction after LT (n=8, 30.7%) was the second most common. Median initial IgM and IgG anti-ABO titers for ABOi LT recipients were 1:16 (range, 1:8-1:128) and 1:48 (range, 1:8-1:2048). We performed preoperative TPE in 10 recipients (median number of sessions, 1.5; range, 1-11). Among patients with early graft dysfunction, those who underwent living donor LT had better survival (4/4; 100%) than those who underwent nonliving donor LT (0/3; 0%). Patients who underwent living donor LT first and then additional LT also survived after three TPE sessions.nnnCONCLUSIONnTherapeutic apheresis is associated with a good survival rate and is essential for liver support in patients with early graft dysfunction after LT or posthepatectomy liver failure and during preparation for ABOi LT.


Surgery | 2017

Do hepatic-sided tumors require more extensive resection than peritoneal-sided tumors in patients with T2 gallbladder cancer? Results of a retrospective multicenter study

Woohyung Lee; Chi-Young Jeong; Jae Yool Jang; Young Hoon Kim; Young Hoon Roh; Kwan Woo Kim; Sung Hwa Kang; Myung Hee Yoon; Hyung Il Seo; Sung Pil Yun; Jeong-Ik Park; Bo-Hyun Jung; Dong Hoon Shin; Young Il Choi; Hyung Hwan Moon; Chong Woo Chu; Je Ho Ryu; Kwangho Yang; Young Mok Park; Soon-Chan Hong

Background: Tumor location is a prognostic factor for survival in patients with T2 gallbladder cancer. However, the optimal extent of resection according to tumor location remains unclear. Methods: We reviewed the records of 192 patients with T2 gallbladder cancer who underwent R0 or R1 resection at 6 institutions. Perioperative and oncologic outcomes were compared according to the extent of resection between hepatic‐sided (n = 93) and peritoneal‐sided (n = 99) tumors. Results: After a median follow‐up of 30 months, the 5‐year overall survival (84.9% vs 71.8%, P = .048) and recurrence‐free survival (74.6% vs 62.2%, P = .060) were greater in peritoneal‐sided T2 patients than in hepatic‐sided T2 patients. Among hepatic‐sided T2 patients, the 5‐year overall survival was greater in patients who underwent radical cholecystectomy including lymph node dissection with liver resection than in patients who underwent lymph node dissection without liver resection (80.3% vs 30.0%, P = .032), and the extent of liver resection was not associated with overall survival (P = .526). Lymph node dissection without liver resection was an independent prognostic factor for overall survival in hepatic‐sided T2 gallbladder cancer (hazard ratio 5.009, 95% confidence interval 1.512–16.596, P = .008). In peritoneal‐sided T2 patients, the 5‐year overall survival was not significantly different between the lymph node dissection with liver resection and the lymph node dissection without liver resection subgroups (70.5% vs 54.8%, P = .111) and the extent of lymph node dissection was not associated with overall survival (P = .395). Conclusion: In peritoneal‐sided T2 gallbladder cancer, radical cholecystectomy including lymph node dissection without liver resection is a reasonable operative option. Radical cholecystectomy including lymph node dissection with liver resection is suitable for hepatic‐sided T2 gallbladder cancer.


Journal of The Korean Surgical Society | 2012

More than 7-year survival of a patient following repeat hepatectomy for total 20 colon cancer liver metastases

Kwang Ho Yang; Je Ho Ryu; Ki Myung Moon; Chong Woo Chu

A 54-year-old man was transferred with sigmoid colon cancer combined with multiple bilobar liver metastases. Nine metastases were in the left lobe and 5 metastases were in the right lobe. After low anterior resection, all 9 lesions in the left lobe were completely removed by wedge resections. Because the remnant liver volume after multiple wedge resection of the left lobe was not sufficient to perform a right hepatectomy simultaneously, we planned a two-stage hepatectomy. Right portal vein embolization was performed one week after the first liver operation. A right hepatectomy was safely performed 22 days after the first hepatectomy. A recurrent mass developed in the segment III 18 months after the right hepatectomy. Radiofrequency ablation (RFA) was performed to remove that lesion. Five other metastases developed 18 months after RFA whereby multiple wedge resections were performed. The patient has survived for more than 7 years after the first liver operation.


The Korean Journal of Blood Transfusion | 2012

A First Experience of Rh(D) Incompatible Living Related Liver Transplantation in Korea

Seung Hee Lee; Chong Woo Chu; Kwang Ho Yang; Je Ho Ryu; Ki Myung Moon; Hyung Hoi Kim

Collaboration


Dive into the Je Ho Ryu's collaboration.

Top Co-Authors

Avatar

Chong Woo Chu

Pusan National University

View shared research outputs
Top Co-Authors

Avatar

Kwang Ho Yang

Pusan National University

View shared research outputs
Top Co-Authors

Avatar

Byung Hyun Choi

Pusan National University

View shared research outputs
Top Co-Authors

Avatar

Tae Beom Lee

Pusan National University

View shared research outputs
Top Co-Authors

Avatar

Young Mok Park

Pusan National University

View shared research outputs
Top Co-Authors

Avatar

Kwangho Yang

Pusan National University

View shared research outputs
Top Co-Authors

Avatar

Hyun-Ji Lee

Pusan National University

View shared research outputs
Top Co-Authors

Avatar

Ki Myung Moon

Pusan National University

View shared research outputs
Top Co-Authors

Avatar
Top Co-Authors

Avatar

Su Jin Lee

Pusan National University

View shared research outputs
Researchain Logo
Decentralizing Knowledge