Je-Tae Woo
University of the Ryukyus
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Publication
Featured researches published by Je-Tae Woo.
International Immunopharmacology | 2013
Se-Eun Jang; Kwon-Ryeol Ryu; Sung-Hwan Park; Suna Chung; Yuto Teruya; Myung Joo Han; Je-Tae Woo; Dong-Hyun Kim
Nobiletin and tangeretin are polymethoxy flavonoids that are abundantly present in the pericarp of Citrus unshiu (family Rutaceae) and the fruit of Citrus depressa (family Rutaceae). They exhibit various biological activities, including anti-inflammatory and anti-asthmatic effects. To evaluate the anti-allergic effects of nobiletin and tangeretin, we measured their inhibitory effects in histamine- or compound 48/80-induced scratching behavioral mice. Nobiletin and tangeretin potently inhibited scratching behavior, as well as histamine-induced vascular permeability. Furthermore, they inhibited the expression of the allergic cytokines, IL-4 and TNF-α as well as the activation of their transcription factors NF-κB, AP-1 and p38 in histamine-stimulated skin tissues. They also inhibited the expression of IL-4 and TNF-α and the activation of NF-κB and c-jun in PMA-stimulated RBL-2H3 cells. Furthermore, nobiletin and tangeretin inhibited protein kinase C (PKC) activity and the IgE-induced degranulation of RBL-2H3 cells. These agents showed potent anti-histamine effect through the Magnus test when guinea pig ileum was used. Based on these results, nobiletin and tangeretin may ameliorate scratching behavioral reactions by inhibiting the action of histamine as well as the activation of the transcription factors NF-κB and AP-1 via PKC.
Archive | 2010
Young-Sil Lee; Byung-Yoon Cha; xiao-xing Wang; Sun-Sil Choi; Bong-Keun Choi; Hiroshi Yamakawa; Kiyoto Saito; Takayuki Yonezawa; Toshiaki Teruya; Kazuo Nagai; Je-Tae Woo
Archive | 2007
Kun-Hyung Lee; Byung-Yoon Cha; Takayuki Yonezawa; Shin-ichi Hasegawa; Je-Tae Woo; Kazuo Nagai
Archive | 2013
Midori Asai; Young-Sil Lee; Naomi Mase; Bong-Keun Choi; Byung-Yoon Cha; Takayuki Yonezawa; Toshiaki Teruya; Kazuo Nagai; Je-Tae Woo
Archive | 2007
Takayuki Yonezawa; Hiroyuki Akazawa; Byung-Yoon Cha; Toshiaki Teruya; Je-Tae Woo; Masato Ohta
Archive | 2013
Toshiaki Teruya; Yuto Teruya; Saki Sugiyama; Je-Tae Woo
ics.org | 2016
Yoshihiko Ito; Mikina Matsui; Eriko Hikiyama; Eri Yoshikawa; Je-Tae Woo; Yuto Teruya; Tosiaki Teruya; Shizuo Yamada
Archive | 2015
伊藤 由彦; Yoshihiko Ito; 恵梨子 引山; Eriko Hikiyama; 静雄 山田; Shizuo Yamada; 済泰 禹; Je-Tae Woo; 勇人 照屋; Yuto Teruya; 公男 菅谷; Kimio Sugaya; さおり 西島; Saori Nishijima; 浩一 和久田; Hirokazu Wakuda; 和正 篠塚; Kazumasa Shinozuka
Archive | 2014
Je-Tae Woo; Masato Ohta; Takayuki Yonezawa; Toshiaki Teruya; Byung-Yoon Cha; Kazuo Nagai
Archive | 2013
Takayuki Yonezawa; Je-Tae Woo; Kazumi Yagasaki