Jean Demonty
University of Liège
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Featured researches published by Jean Demonty.
Acta Clinica Belgica | 1994
Michel Moutschen; Jean-Marc Triffaux; Jean Demonty; Jean-Jacques Legros; Pierre Lefebvre
This review analyses the recent literature devoted to two related fatigue syndromes: chronic fatigue syndrome (CFS) and acute onset postviral fatigue syndrome (PVFS). The articles are grouped into five pathogenic tracks: infectious agents, immune system, skeletic muscle, hypothalamo-pituitary-adrenal (HPA) axis and psychiatric factors. Although a particular infectious agent is unlikely to be responsible for all CFS cases, evidence is shown that host-parasite relationships are modified in a large proportion of patients with chronic fatigue. Antibody titres against infectious agents are often elevated and replication of several viruses could be increased. Chronic activation of the immune system is also observed and could be due to the reactivation of persistent or latent infectious agents such as herpes viruses (i.e. HHV-6) or enteroviruses. It could also be favorised by an impaired negative feedback of the HPA axis on the immune system. A model is proposed where the abnormalities of the HPA axis are primary events and are mainly responsible for a chronic activation of the immune system which in turn induces an increased replication of several viruses under the control of cellular transcription factors. These replicating viruses together with cytokines such as TNF-alpha would secondarily induce functional disorders of muscle and several aspects of asthenia itself.
Acta Clinica Belgica | 2010
Jean Demonty; Michel Gonce; P. Ribai; C. Verellen-Dumoulin; Roland Hustinx
Abstract A seventeen year-old boy developed left sided chorea in a few days, subsequently involving the four limbs. Although he presented a marfanoid phenotype, genetic analysis of the Fibrillin 1 was normal. The genes for familial chorea and Huntington’s disease were also negative. Biological tests showed normal serum homocystein, but revealed very high levels of anti-β2-GP1 IgG, anticardiolipin and lupus anticoagulant, which remained at similar values for a period of over three months. Electroencephalogram and cerebral magnetic resonance imaging (MRI) showed no abnormalities. Brain PET-scan disclosed bilateral striatal hypermetabolism. The patient was treated with methylprednisolone and low dose of acetylsalicylic acid. He improved markedly after six weeks of treatment, and choreic movements disappeared completely after two months. A control PET-scan performed at this time showed reversion of striated hypermetabolism to a normal pattern. The pathogenic aspects of this relatively rare case of chorea are discussed.
Medecine Et Maladies Infectieuses | 2008
D. Nkoghe; Michel Moutschen; Jean Demonty
We report the case of a 32-year-old immunocompetent HIV patient, presenting with acute demyelinating leukoencephalopathy. The patient displayed clinical and radiological features similar to multiple sclerosis. Histology revealed inflammation with necrosis, demyelination and destruction of axons. Serum tests were negative for various infectious agents as well as specific cultures and PCR. Corticotherapy and many antibiotic treatments failed. Resorption of the lesions occurred after partial excision and highly-active antiretroviral therapy (HAART). No recurrence was noted. This demyelinating cerebral disease was considered as the primary manifestation of HIV infection. HIV implication in the genesis of the process and its perpetuating this condition was suspected, but the mechanism is unclear. Dysimmune consequences related to the early course of HIV infection could be prevented by antiretroviral treatment. This study was the first description of tritherapy effectiveness on HIV related multiple sclerosis (MS)-like illness.
Revue de Médecine Interne | 2002
Tarik Belhocine; O. Kaye; Pierre Delanaye; Vincianne Corman; M. Baghaie; Manuel Deprez; Frédéric Daenen; C. De Barsy; Catherine Beckers; Pierre Gomez; Roland Hustinx; Jacqueline Foidart-Willems; Jean Demonty; Michel Malaise; Pierre Rigo
Acta Gastro-enterologica Belgica | 2002
Katty Delbecque; Olivier Detry; Marie-Pierre Hayette; Jeukens T; Philippe Delvenne; Noëlle Hardy; Jean Delwaide; Jean Demonty; Jacques Boverie; Demol P; Hauwaert C; Pierre Honore; Jacques Boniver; Nicolas Jacquet
Acta Gastro-enterologica Belgica | 2005
Charles Honore; Olivier Detry; Odile Wauters; Jean Delwaide; Jean Demonty; Albert Thiry; Arnaud De Roover; Michel Meurisse; Jacques Belaiche; Pierre Honore
Revue médicale de Liège | 2002
D. Nkoghe; Philippe Leonard; S. Nnegue; Michel Moutschen; Jean Demonty
Medecine Et Maladies Infectieuses | 2004
D. Nkoghe; S. Nnégué; P. Léonard; Michel Moutschen; Jean Demonty
Revue médicale de Liège | 2003
Philippe Leonard; Michel Moutschen; Jean Demonty
Revue médicale de Liège | 2001
Philippe Leonard; D. Nkoghe; Michel Moutschen; Jean Demonty