Jean M. Patterson

Solubility of tissue phosphatides in acetone

Abstract Treatment of plant and animal tissues with acetone extracted considerable amounts (from about 10 to 95%) of the total phosphatides. Of the animal organs tested, muscle gave up the largest proportion of its phosphatides to acetone, brain the least. Considerable unsuspected loss of phosphatides may occur if acetone is used for preliminary drying of tissues or to remove simple lipides.

Effects of Growth Hormone on the Transport of Lipids in Blood

The view is widely held that the forms in which lipids are carried in the blood may be of importance in atherosclerosis and related disorders. A comparative study of lipid transport under the conditions of mobilization of fat from the body depots and of absorption of fat from the intestine was therefore undertaken. Mobilization was induced by fasting and by the administration of purified growth hormone. Fat absorption, with ensuing movement of lipid towards the depots, was obtained by feeding a fat meal. Lipid transport was also studied under conditions of increased fat utilization in the prediabetic state caused by repeated injections of growth hormone in regularly fed dogs. The results demonstrate marked differences in the amounts and characteristics of the lipids transported in blood under these conditions.