Jean Marie Kasia

Pregnancy outcome at advanced maternal age in a group of African women in two teaching Hospitals in Yaounde, Cameroon.

Introduction Women older than 40 years have been termed “advanced maternal age” and considered to be at risk of adverse pregnancy outcome. This study aimed to examine the obstetrical outcomes among primiparous and multiparous African advanced maternal age women. Methods We conducted a retrospective cohort study study at two teaching hospitals at Yaounde, Cameroon. From the hospital records, obstetrical characteristics of 585 consecutive women aged 40 or above who delivered from January 2007 to December 2011 were compared with those of 1816 younger mothers aged 20 to 29 years as control cases. Associations between maternal age and selected obstetrical variables were assessed with the contigency X2 test or two-tailed Fisher exact test. Results Primiparous and multiparous advanced maternal age were more likely to undergo cesarean delivery than were their younger counterparts (38.5% vs 13.5%, RR=2.85, p<0.05 and 16.1% vs 9.1%, RR=1.76, p<0.05). Older primiparous women had similar perinatal outcomes than their younger counterparts. Older multiparous women had increased incidence of preeclampsia/eclampsia (2.4% vs 0.6%, RR=4, p<0.01); antepartum hemorrhage (1.8% vs 0.8%, RR=2.25, p<0.01); fetal distress (3.5% vs 1.3%, RR=2.69, p<0.01); fetal death (3.5% vs 1.6%, RR= 2.18, p<0.05); postpartum hemorrhage (2.4% vs 1.2%; RR=2, p<0.05); preterm delivery (12% vs 9.2%, RR=1.30, p<0.05); low birth weight (11% vs 7.7%, RR=1.42, p<0.05); admission to special care neonatalogy unit(14.1% vs 10.2%, RR=1.38, p<0.05); low Apgar scores at 1min and 5min; and perinatal mortality (3.5% vs 1.6, RR=2.18, p<0.05). Conclusion Advanced maternal age women are at higher risk to cesarean delivery. Increased risk of antepartum and intra partum complications among multiparous advanced maternal age women were associated to adverse perinatal outcome. Our results are in concordance with the view that increased risk of adverse perinatal outcome with advanced maternal age is indirectly related to age through the increased risk of obstetrical complications associated with age.

Nuchal Cord and Perinatal Outcome at the Yaounde General Hospital, Cameroon

The aim of this study was to determine the incidence of nuchal cord at delivery and perinatal outcome. We conducted a retrospective descriptive study from 1992–2008 at the Yaounde General Hospital. Obstetrical and neonatal variables were compared in the loose and tight nuchal cord groups and a control group (no nuchal cord). Of 9275 deliveries recorded, 16.2% had a nuchal cord. Of these nuchal cords, 75.81% were loose and 24.18% were tight. Cesarean delivery rate was lower in the loose and tight nuchal cord groups when compared with control group (P <.001;P < .05). Low Apgar scores < 7 at the 1st and 5th minutes were less in the loose nuchal cord group when compared with control group (P = .06, P = .7). In tight nuchal cord group, low Apgar score < 7 at the 1st minute was significantly higher, when low Apgar score < 7 at the 5th minute was non significantly higher when compared with control group (P < .001, P = .14). Transfer rate to neonatology unit was lower in the loose and tight nuchal cord than in the control group. Loose nuchal cord may not be associated with adverse perinatal outcome. However, tight nuchal cord may be associated with increased risk of low Apgar score < 7 at the 1st minute. Consequently, the ultrasound diagnosis of a nuchal cord at the end of pregnancy should not be the indication of elective cesarean delivery.

References of Birth Weights for Gestational Age and Sex from a Large Cohort of Singleton Births in Cameroon

Objective. To establish the percentile charts of birth weights for gestational age and sex within the Cameroonian population. Methods. A review of medical records of infants born between January 2007 and December 2011 at the maternities of two hospitals in Cameroon, Central Africa. Multiple pregnancies, births of HIV infected women, stillbirths, and births with major fetal malformations were excluded. The smooth curves of birth weight for gestational age and sex were created using the Gamlss package under R.3.0.1 software. Results. The birth weights of 12837 live birth singleton infants born to HIV negative women between 28 and 42 weeks of gestation were analyzed to construct the birth weight curves for gestational age and sex. The smoothed percentile curves of birth weights for gestational age and sex of Cameroonian infants have demonstrated an increasing slope until 40 weeks and then a plateau. There was a varied difference of distribution in birth weights for gestational age between Cameroonian, Botswanan, American, and French infants. Conclusion. We established the reference curves of birth weights for gestational age and sex for Cameroonians. The difference in birth weight curves noted between Cameroonian, Botswanan, American, and French infants suggests the importance of establishing the regional birth weight norms.

Successful management of pregnancy in an African woman with Klippel Trenaunay syndrome.

Klippel Trenaunay syndrome (KTS) is a rare congenital disease characterized by a triad of cutaneous hemangioma, varicose veins and bone or soft tissue hypertrophy. Cases of pregnancy complicated by KTS are rare. There is an increased risk of thrombo-embolic disease and hemorrhage during pregnancy. Both obstetric and anesthetic management of KTS in pregnancy can be rather complicated. We present a successful management of pregnancy in an African woman with KTS at Yaounde General Hospital, Cameroon.

Accuracy of saline infusion sonography versus hysteroscopy in the evaluation of uterine cavity abnormalities in infertile women at CHRACERH, Yaounde, Cameroon

Uterine cavity abnormalities are seen as a cause of infertility in around 10%-15% of women. In women with recurrent implantation failure abnormalities are found in up to 50% of the women. Evaluation of the uterine cavity is a basic step in the investigation of infertile women because the most critical step for successful IVF outcome is embryo implantation, which is influenced by a positive cross talk between an adequate quality embryo and a receptive endometrium.

Comparison of hysterosalpingograms with laparoscopy in the diagnostic of tubal factor of female infertility at the Yaounde General Hospital, Cameroon.

Introduction The objectives were to assess the diagnostic value of hysterosalpingography (HSG) with laparoscopy as gold standard in the evaluation of tubal patency and pelvic adhesions in women suffering from infertility. Methods We conducted a comparative cross sectional study on 208 medical files of infertile women followed up at the Yaoundé General Hospital during a period of five years (December 2007 to December 2012). Tubal patency, hydrosalpinx and pelvic adhesions detected at HSG were compared with laparoscopic findings as the gold standard. The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and diagnostic accuracy of HSG were calculated with 95% confidence interval (CI). Results Mean age of the patients was 31.4± 6.45 years. Secondary infertility was the most frequent type of infertility (66.82%). HSG had a moderate sensitivity (51.0%; 95% IC. 37.5-64.4), high specificity (90.0%; 95% IC.74.4-96.5), high PPV (89.3%; 95% IC. 72.8-96.3) and a moderate NPV (52.9%; 95% IC. 39.5-65.9) in the diagnosis of bilateral proximal tubal occlusion. Concerning, distal tubal patency, HSG had a high sensitivity (86.8%; 95% IC. 76.7-92.9), low specificity (42.2%; 95% CI. 29.0-56.7), moderate PPV (69.4%; 95% IC. 58.9-78.2) and a moderate NPV (67.9%; 95% IC. 49.3-82.0) in the diagnosis of bilateral or unilateral distal tubal occlusion. However, HSG had a low diagnostic value (27.8%; 95%IC.18.8-39.0) in the pelvic adhesions. Conclusion HSG is of limited diagnostic value in tubal factor infertility and is of low diagnostic value for pelvic adhesions.