Jean Mathieu

Conformation et cinétique d'oxydation des α,β-amino-alcools aliphatiques diastéréoisomères

A study of the splitting of the diastereoisomers of α,β-aminoalcohols with lead tetraacetate makes it possible to differentiate between the threo- and erythro- forms. Spectrophotometric analyses of the lead(lV) salts have shown that threonine, pseudo-norephedrine, threo- 1-p-nitro-phenyl-2-amino-propane-1,3-diol (ground substance of chloramphenicol) and its non-nitrated analogue are more rapidly oxidized than the isomers of the erythro-series. There is no difference in the rate of oxidation when substituents are attached to the nitrogen.