Network


Latest external collaboration on country level. Dive into details by clicking on the dots.

Hotspot


Dive into the research topics where Jean-Maurice Mallet is active.

Publication


Featured researches published by Jean-Maurice Mallet.


Journal of Carbohydrate Chemistry | 1999

Synthesis of the β-Methyl Glycoside of Lacto-N-Fucopentaose III

Yongmin Zhang; Jacques Esnault; Jean-Maurice Mallet; Pierre Sinay

ABSTRACT A total synthesis of the β-methyl glycoside of lacto-N-fucopentaose III (1) is described. Phenyl 2,3,4,6-tetra-O-benzoyl-β-D-galactopyranosyl-(1→4)-6-O-benzyl-2-deoxy-2-phthalimido-1-thio-β-D-glucopyranoside (4), a key intermediate prepared by condensation of 2,3,4,6-tetra-O-benzoyl-α-D-galactopyranosyl bromide (2) and phenyl 6-O-benzyl-2-deoxy-2-phthalimido-1-thio-β-D-glucopyranoside (3), was glycosylated with ethyl 2,3,4-tri-O-benzyl-1-thio-β-L-fucopyranoside (5) to give the trisaccharide donor 6, which, on coupling with methyl 2,6-di-O-benzyl-β-D-galactopyranosyl-(1→4) 2,3,6-tri-O-benzyl-β-D-glucopyranoside (7), afforded the pentasaccharide 8. It was easily transformed into the target pentasaccharide 1 via hydrazinolysis, acetylation, O-deacetylation, and hydrogenolysis.


Journal of Chemical Biology | 2010

Glycosylated cell-penetrating peptides and their conjugates to a proapoptotic peptide: preparation by click chemistry and cell viability studies

Laurence Dutot; Pascaline Lécorché; Fabienne Burlina; Rodrigue Marquant; Vanessa Point; Sandrine Sagan; Gérard Chassaing; Jean-Maurice Mallet; Solange Lavielle

Cell-penetrating peptides (CPPs), which are usually short basic peptides, are able to cross cell membranes and convey bioactive cargoes inside cells. CPPs have been widely used to deliver inside cells peptides, proteins, and oligonucleotides; however, their entry mechanisms still remain controversial. A major problem concerning CPPs remains their lack of selectivity to target a specific type of cell and/or an intracellular component. We have previously shown that myristoylation of one of these CPPs affected the intracellular distribution of the cargo. We report here on the synthesis of glycosylated analogs of the cell-penetrating peptide (R6/W3): Ac-RRWWRRWRR-NH2. One, two, or three galactose(s), with or without a spacer, were introduced into the sequence of this nonapeptide via a triazole link, the Huisgen reaction being achieved on a solid support. Four of these glycosylated CPPs were coupled via a disulfide bridge to the proapoptotic KLAK peptide, (KLAKLAKKLAKLAK), which alone does not enter into cells. The effect on cell viability and the uptake efficiency of different glycosylated conjugates were studied on CHO cells and were compared to those of the nonglycosylated conjugates: (R6/W3)S-S-KLAK and penetratinS-S-KLAK. We show that glycosylation significantly increases the cell viability of CHO cells compared to the nonglycosylated conjugates and concomitantly decreases the internalization of the KLAK cargo. These results suggest that glycosylation of CPP may be a key point in targeting specific cells.


Gastroenterology | 2006

Candida albicans Is an Immunogen for Anti–Saccharomyces cerevisiae Antibody Markers of Crohn’s Disease

Annie Standaert–Vitse; Thierry Jouault; Peggy Vandewalle; Céline Mille; Mimouna Seddik; Boualem Sendid; Jean-Maurice Mallet; Jean-Frédéric Colombel; Daniel Poulain


Organic Letters | 2007

Synthesis and Characterization of a New Red-Emitting Ca2+ Indicator, Calcium Ruby

Stéphane Gaillard; Aleksey Yakovlev; Camilla Luccardini; Martin Oheim; and Anne Feltz; Jean-Maurice Mallet


Archive | 2006

Synthetic oligomannosides, preparation and uses thereof

Jacques Esnault; Pierre Sinaÿ; Reynald Chevalier; Jean-Frédéric Colombel; Jean-Maurice Mallet; Boualem Sendid; Thierry Jouault; Daniel Poulain; Pierre-André Trinel


Synlett | 1998

Stereoselective Synthesis of α-C-l-Fucopyranosyl Containing C-Disaccharides

El Djouhar Rekaï; Gilles Rubinstenn; Jean-Maurice Mallet; Pierre Sinay; Stephan N. Müller; Bernd Giese


Radicals in Organic Synthesis | 2008

Radicals in Carbohydrate Chemistry

Alan J. Pearce; Jean-Maurice Mallet; Pierre Sinaÿ


Heterocycles | 2000

One-Step Synthesis of Disaccharide Mimetics via Tandem Rearrangement of Unsaturated Disaccharides

Alan James Pearce; Jean-Maurice Mallet; Pierre Sinay


Archive | 2000

Oligomannosides de synthese, leur preparation et leurs utilisations

Jacques Esnault; Pierre Sinaÿ; Reynald Chevalier; Jean-Frédéric Colombel; Jean-Maurice Mallet; Boualem Sendid; Thierry Jouault; Daniel Poulain; Pierre-André Trinel


231st ECS Meeting (May 28 - June 1, 2017) | 2017

NBD-Ferrocene: A New Fluorescence Redox Molecular Switch Based on Photoinduced Electron Transfer

Martina Čížková; Laurent Cattiaux; Jean-Maurice Mallet; Eric Labbé; Olivier Buriez

Collaboration


Dive into the Jean-Maurice Mallet's collaboration.

Top Co-Authors

Avatar
Top Co-Authors

Avatar

Pierre Sinaÿ

École Normale Supérieure

View shared research outputs
Top Co-Authors

Avatar
Top Co-Authors

Avatar

Reynald Chevalier

École Normale Supérieure

View shared research outputs
Top Co-Authors

Avatar

Pierre Sinay

Centre national de la recherche scientifique

View shared research outputs
Top Co-Authors

Avatar

Aleksey Yakovlev

Centre national de la recherche scientifique

View shared research outputs
Top Co-Authors

Avatar

Eric Labbé

Centre national de la recherche scientifique

View shared research outputs
Top Co-Authors

Avatar

Laurent Cattiaux

Centre national de la recherche scientifique

View shared research outputs
Top Co-Authors

Avatar

Olivier Buriez

Centre national de la recherche scientifique

View shared research outputs
Top Co-Authors

Avatar

Alan J. Pearce

École Normale Supérieure

View shared research outputs
Researchain Logo
Decentralizing Knowledge