Jean-Pierre Bianchini

Screening of anti-HIV-1 inophyllums by HPLC–DAD of Calophyllum inophyllum leaf extracts from French Polynesia Islands

Various pyranocoumarins, calophyllolide, inophyllums B, C, G(1), G(2) and P, from Calophyllum inophyllum (Clusiaceae) leaves of French Polynesia (Austral, Marquesas, Society and Tuamotu archipelagos) have been determined in 136 leaf extracts using a high pressure liquid chromatography-UV-diode array detection (HPLC-UV-DAD) technique. Results show a wide range in chemical composition within trees growing on eighteen islands. The use of multivariate statistical analyses (PCA) shows geographical distribution of inophyllums and indicate those rich in HIV-1 active (+)-inophyllums. Inophyllum B and P contents (0.0-39.0 and 0.0-21.8 mg kg(-1), respectively) confirm the chemodiversity of this species within the large area of French Polynesia. The study suggests the presence of interesting chemotypes which could be used as plant source for anti-HIV-1 drugs.

Retracted Article: A New Chemotype of Sandalwood (Santalum insulare Bertero ex A. DC.) from Marquesas Islands

Abstract Volatile constituents of sandalwood (Santalum insulare) concrete from the island of Nuku-Hiva in Marquesas Islands were studied using GC, GC/MS, HPLC and NMR. The investigation of nine main compounds showed important variations among sandalwood samples (from 3.5–53.2% for α-santalol and from trace to 29.3% for (Z)-nuciferol). Statistical analysis put in relief a geographical segregation between sandalwoods growing in dry area in Terre-Déserte (14.6% of α- and β-santalol, 17.1% of (Z)-nuciferol and 11.7% of 6,13-dihydroxybisabola-2,10-diene) and sandalwoods growing in wetter area of the other parts of the island (60.9% of α- and β-santalol, 1.2% of (Z)-nuciferol and 0.7% of 6,13-dihydroxybisabola-2,10-diene). The chemotype rich in (Z)-nuciferol of Terre-Déserte constitutes a rare and new chemotype, which is described for the first time.

A New Chemotype of Sandalwood (Santalum insulare Bertero ex A. DC.) from Marquesas Islands

Abstract Volatile constituents of sandalwood (Santalum insulare) concrete from the island of Nuku-Hiva in Marquesas Islands were studied using GC, GC/MS, HPLC and NMR. The investigation of nine main compounds showed important variations among sandalwood samples (from 3.5–53.2% for α-santalol and from trace to 29.3% for (Z)-nuciferol). Statistical analysis put in relief a geographical segregation between sandalwoods growing in dry area in Terre-Déserte (14.6% of α- and β-santalol, 17.1% of (Z)-nuciferol and 11.7% of 6,13-dihydroxybisabola-2,10-diene) and sandalwoods growing in wetter area of the other parts of the island (60.9% of α- and β-santalol, 1.2% of (Z)-nuciferol and 0.7% of 6,13-dihydroxybisabola-2,10-diene). The chemotype rich in (Z)-nuciferol of Terre-Déserte constitutes a rare and new chemotype, which is described for the first time.

New tricyclic and tetracyclic pyranocoumarins with an unprecedented C‐4 substituent. Structure elucidation of tamanolide, tamanolide D and tamanolide P from Calophyllum inophyllum of French Polynesia

Three new pyranocoumarin derivatives, tamanolide (1), tamanolide D (2) and tamanolide P (3), were isolated from the almond seeds of Calophyllum inophyllum L. (Clusiaceae) grown in French Polynesia. These compounds, having an unprecedented C‐4 isobutyl substituent, have been characterized as a new class of pyranocoumarins called tamanolides. Their structures were elucidated on the basis of 1D and 2D NMR techniques (COSY, NOESY, HSQC and HMBC) in association with MS (HR‐ESI‐MS) data analysis. Copyright