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Featured researches published by Jean-Pierre Ganière.


Veterinary Microbiology | 1994

Recognition of Leptospira interrogans antigens by vaccinated or infected dogs.

X. Gitton; M. Buggin Daubié; François Andre; Jean-Pierre Ganière; Geneviève André-Fontaine

Antigenic recognition of leptospiral antigens by vaccinated or infected dogs was studied by microagglutination test (MAT) and by western blots. In western blots, serovar specific antigens detected by MAT migrated in the 18-31 kDa zone. The 25-31 zone seemed to be linked to antigens indicating virulence of the strain. These antigens are LPS. The first antibodies made after infection are produced against LPS migrating in the 14 kDa zone. Many protein antigens are common in leptospires belonging to different serogroups. Virulent strains exhibited specific antigens in the 45 and 32-34 kDa zones.


Veterinary Microbiology | 1992

Immunoblotting study of the antigenic relationships among eight serogroups of Leptospira

Xavier Gitton; Geneviève André-Fontaine; François Andre; Jean-Pierre Ganière

Seven strains of Leptospira interrogans belonging to seven different serogroups, and one strain of Leptospira biflexa were analysed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) with gradient gels and immunoblotting with hyperimmune rabbit sera raised against each strain. The molecular masses of the proteins were calculated with a polynomial regression model. The SDS-PAGE patterns of the L. interrogans strains were similar and characterized by 24 common bands. This profile was not found for L. biflexa. The immunoblots obtained either with the seven anti-L. interrogans sera or the anti-L. biflexa serum allowed a clear distinction between the two species. Taken as a whole, the L. interrogans strain patterns revealed by the seven anti-L. interrogans sera were similar, sharing eight common major bands. A serovar- or serogroup-specific antigenic zone, ranging from 21 to 26 kDa, was also identified.


Research in Virology | 1995

Partial characterization of the human erythrocyte receptor for rabbit haemorrhagic disease virus

Nathalie Ruvoën-Clouet; D. Blanchard; Geneviève André-Fontaine; Jean-Pierre Ganière

An important, well known property of the rabbit haemorrhagic disease virus is its ability to agglutinate human red blood cells. Accordingly, red cells from human adult donors were agglutinated despite their blood group ABO status, and treatments with proteases or glycosidases did not prevent agglutination. However, we discovered that the cells from human umbilical cords or foetuses were not agglutinated. In order to identify the viral receptor on human erythrocytes, glycolipids and glycoproteins from adult red cells were separated and tested for their potency in inhibiting agglutination. The bulk of the biological activity was associated with the highly glycosylated glycolipids (polyglycosylceramides), whereas a lower but significant activity was also associated with neutral glycolipids. No activity was found in the lipid-free sialoglycoprotein fractions. All these data strongly suggest that the RHDV receptor on human red cells corresponds to a development antigen which is not expressed on foetal cells and is mainly carried by glycolipids. Faint activity was also found in membranes from sheep red cells, suggesting that a similar glycolipid component is carried by these animal cells.


Research in Veterinary Science | 1993

Effect of stage of æstrous cycle on tylosin disposition in genital tract secretions of cows

C.C. Cester; Jean-Pierre Ganière; P.L. Toutain

The influence of physiological state (oestrous or luteal phase) on tylosin disposition in genital secretions was examined after intravenous administration of tylosin to cows. Six healthy, cyclic and non-lactating dairy cows with controlled oestrous cycles were given a single slow intravenous injection of tylosin, at a dose of 10 mg kg-1. Plasma and genital fluid were regularly sampled up to 48 hours after injection. Tylosin diffused from blood to the genital tract and accumulated in genital secretions whatever the stage of the oestrous cycle: the secretion to plasma ratio was 3.45 +/- 2.54 during oestrous and 4.75 +/- 3.24 during the luteal phase. The area under the concentration-time curve (AUC) and the mean residence time (MRT) were significantly higher in genital secretions than in plasma. The AUC and the MRT in genital secretions showed no significant differences during the oestrous cycle. The minimal inhibitory concentrations (MIC) of tylosin for 25 strains of Actinomyces pyogenes were between 0.032 (12 strains) and 0.063 micrograms ml-1 (13 strains). Simulations based on the mean values of pharmacokinetic parameters determined in genital secretions, gave tylosin concentrations higher than the MIC for at least 36 hours. It was concluded that after an intravenous administration of tylosin, effective concentrations were achieved in genital secretions of the cyclic cow whatever its hormonal status which supported its use for the treatment of genital tract infections.


PLOS ONE | 2018

Risk of introduction of lumpy skin disease in France by the import of vectors in animal trucks

Claude Saegerman; Stéphane Bertagnoli; Gilles Meyer; Jean-Pierre Ganière; Philippe Caufour; Kris De Clercq; Philippe Jacquiet; Guillaume Fournié; Claire Hautefeuille; F. Etore; Jordi Casal

Background The lumpy skin disease virus (LSDV) is a dsDNA virus belonging to the Poxviridae family and the Capripoxvirus genus. Lumpy skin diseases (LSD) is a highly contagious transboundary disease in cattle producing major economic losses. In 2014, the disease was first reported in the European Union (in Cyprus); it was then reported in 2015 (in Greece) and has spread through different Balkan countries in 2016. Indirect vector transmission is predominant at small distances, but transmission between distant herds and between countries usually occurs through movements of infected cattle or through vectors found mainly in animal trucks. Methods and principal findings In order to estimate the threat for France due to the introduction of vectors found in animal trucks (cattle or horses) from at-risk countries (Balkans and neighbours), a quantitative import risk analysis (QIRA) model was developed according to the international standard. Using stochastic QIRA modelling and combining experimental/field data and expert opinion, the yearly risk of LSDV being introduced by stable flies (Stomoxys calcitrans), that travel in trucks transporting animals was between 6 x 10−5 and 5.93 x 10−3 with a median value of 89.9 x 10−5; it was mainly due to the risk related to insects entering farms in France from vehicles transporting cattle from the at-risk area. The risk related to the transport of cattle going to slaughterhouses or the transport of horses was much lower (between 2 x 10−7 and 3.73 x 10−5 and between 5 x 10−10 and 3.95 x 10−8 for cattle and horses, respectively). The disinsectisation of trucks transporting live animals was important to reduce this risk. Conclusion and significance The development of a stochastic QIRA made it possible to quantify the risk of LSD being introduced in France through the import of vectors that travel in trucks transporting animals. This tool is of prime importance because the LSD situation in the Balkans is continuously changing. Indeed, this model can be updated to process new information on vectors and the changing health situation, in addition to new data from the TRAde Control and Expert System (TRACES, EU database). This model is easy to adapt to different countries and to other vectors and diseases.


Journal of Veterinary Medicine Series B-infectious Diseases and Veterinary Public Health | 2005

Antimicrobial Drug Susceptibility of Staphylococcus intermedius Clinical Isolates from Canine Pyoderma

Jean-Pierre Ganière; C. Medaille; C. Mangion


Journal of Veterinary Medicine Series B-infectious Diseases and Veterinary Public Health | 1992

Hematological parameters and visceral lesions relationships in rabbit viral hemorrhagic disease

Georges Plassiart; Jean‐François Guelfi; Jean-Pierre Ganière; Bo Wang; Geneviève André-Fontaine; Monique Wyers


Research in Veterinary Science | 2004

In vitro antimicrobial activity of orbifloxacin against Staphylococcus intermedius isolates from canine skin and ear infections

Jean-Pierre Ganière; Christine Médaille; F. Etore


Veterinary Dermatology | 2001

Antimicrobial activity of enrofloxacin against Staphylococcus intermedius strains isolated from canine pyodermas.

Jean-Pierre Ganière; Christine Médaille; Agnes Limet; Nathalie Ruvoen; Geneviève André-Fontaine


Revue Scientifique Et Technique De L Office International Des Epizooties | 2011

A qualitative risk assessment methodology for scientific expert panels.

B. Dufour; L. Plee; François Moutou; D. Boisseleau; C. Chartier; Benoit Durand; Jean-Pierre Ganière; J. Guillotin; Renaud Lancelot; Claude Saegerman; A. Thebault; A.-M. Hattenberger; B. Toma

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Nathalie Ruvoen

École Normale Supérieure

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Gilles Meyer

Institut national de la recherche agronomique

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Jordi Casal

Autonomous University of Barcelona

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François Andre

École Normale Supérieure

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