Jean-Pierre Gorrichon

Optimization of the conversion of d-fructose to 5-hydroxymethyl-2-furancarboxaldehyde in a water-solvent-ion exchanger Triphasic system — Part I. Investigation of the main effects of the major parameters and of their interactions on the reaction

Abstract Two fractional factorial designs were used for the investigation of the synthesis of 5-hydroxymethyl-2-furancarboxaldehyde from d -fructose. The reaction system selected combines an ion-exchanger, used as a catalyst, with an extracting solvent which is not miscible with the aqueous phase containing the sugar, and affords mild operating conditions. The main effect of seven parameters and their interactions on four responses of the reaction system were quantified. An orientation for the optimization of the conversion rate to HMF as well as of the reaction selectivity can thus be proposed.