Jee Hyung Jung
Pusan National University
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Featured researches published by Jee Hyung Jung.
Archives of Pharmacal Research | 1999
Doyeob Kim; Il Sun Lee; Jee Hyung Jung; Sung-Il Yang
Psammaplin A, a natural bromotyrosine derivative from an associated form of two sponges (Poecillastra sp. andJaspis sp.) was found to possess the antimicrobial effect on the Grampositive bacteria, especially on methicillin-resistantStaphylococcus aureus (MRSA). The minimal inhibitory concentration of psammaplin A against twenty one MRSAs ranged from 0.781 to 6.25 μg/ml, while that of ciprofloxacin was 0.391∼3.125 μg/ml. Psammaplin A could not bind to penicillin binding protein, but inhibited the DNA synthesis and the DNA gyrase activity with the respective 50% (DNA synthesis) and 100% (DNA gyrase) inhibitory concentration 2.83 and 100 μ/ml. These results indicate that psammaplin A has a considerable antibacterial activity, although restricted to a somewhat narrow range of bacteria, probably by inhibiting DNA gyrase.
Archives of Pharmacal Research | 1997
Hye Sook Kang; Hae Young Chung; Jee Hyung Jung; Sam Sik Kang; Jae Sue Choi
A strong antioxidant activity, which was measured by the radical scavenging effect on 1,1-diphenyl-2-picrylhydrazyl(DPPH) radical, was detected in the methanol extract ofSalvia miltiorrhiza Bunge (Labiatae). By activity-directed fractionation, compounds 1 and 2 were isolated as antioxidant principles ofS. miltiorrhiza. Compounds 1 and 2 were identified as dimethyl lithospermate and 3-(3,4-dihydroxyphenyl)lactamide, respectively, on the basis of spectral data. The radical scavenging effect of compounds 1 and 2 on DPPH radical exceeded that of L-ascorbic acid which is a well known antioxidant. These two compounds also showed prominent inhibitory activity against free radical generation in dichlorofluorescein (DCF) method and cytoprotective effect againstt-BHP in cultured liver cell.
Phytochemistry | 1995
Jae Sue Choi; Jee Hyung Jung; Hee Jung Lee; Ji Hyun Lee; Sam Sik Kang
Abstract From the seeds of Cassia tora , a new naphthalene glycoside was isolated and characterized as 2- acetyl -3-O-β- d -apiofuranosyloxy -8-O-β- d -glucopyranosyloxy-1,6-dimethoxynaphthalene (cassitoroside).
Phytochemistry | 1998
Hee Jung Lee; Jae Sue Choi; Jee Hyung Jung; Sam Sik Kang
Abstract From the seeds of Cassia tora, an anthraquinone glucoside was isolated and characterized as alaternin 2-O-β- d -glucopyranoside.
Archives of Pharmacal Research | 1996
Jae Sue Choi; Jee Hyung Jung; Hee Jung Lee; Sam Sik Kang
The1H- and13C-NMR spectra of alaternin, aurantio-obtusin, chryso-obtusin, obtusin and 2-glucosyl obtusifolin isolated from the seeds ofCassia tora have been assigned based on HMBC, long-range HETCOR, fully1H-coupled13C-NMR, deuterium isotope experiment, and by comparison with the model compounds.
Archives of Pharmacal Research | 1995
Sam Sik Kang; Ju Sun Kim; Jee Hyung Jung; Young Hee Kim
Two furofuran lignans, sesamolin and sesangolin were isolated from the seeds ofSesamum indicum andS. angolense, respectively. Detailed analysis of the1H- and13C-NMR spectra of these lignans was carried out by the application of two-dimensional1H-1H COSY and1H-13C multiple-bond, multiple-quantum spectroscopic correlation techniques.
Archives of Pharmacal Research | 1998
Jee Hyung Jung; Youngsoo Kim; Chong-Ock Lee; Sam Sik Kang; Jong-Hee Park; Kwang Sik Im
The crude extract ofSaussurea lappa displayed significant lethality to brine shrimp larvae. Investigation of the causative components by bioactivity-directed fractionation resulted in the isolation of three C17-polyene alcohols. Based on various nmr spectral data, these compounds were idenfitied as shikokiols which had been previously isolated fromCirsium nipponicum and/orCentaurea aegyptica. These C17-polyene alcohols exhibited moderate cytotoxicities against the human tumor cell lines, A549, SK-OV-3, SK-MEL-2, XF498, and HCT15.
Archives of Pharmacal Research | 1994
Sam Sik Kang; Eun Bang Lee; Tae Hee Kim; Kyung Ran Kim; Jee Hyung Jung
A guaian type sesquiterpene, torilin, was isolated from the hexane extract of the fruits ofTorilis japonica. The1H- and13C-signals of this compound have been fully assigned utilizing1H-1H COSY, HMQC, and HMBC experiments.
Archives of Pharmacal Research | 1997
Dae Keun Kim; Sang Hoon Choi; Jung Ock Lee; Shi Yong Ryu; Dae Kyu Park; Dae Hee Shin; Jee Hyung Jung; Suhk Keung Pyo; Kang Ro Lee; Ok Pyo Zee
The acivity-guided fractionation upon the MeOH extract of the aerial parts ofSorbaria sorbifolia var.stellipila led to the isolation of two cucurbitacin-compounds, cucurbitacin D and cucurbitacin F, as active principles. Two compounds were shown to exhibit significant cytotoxicity against cultured human tumor cell lines, A-549, SK-OV-3, SK-MEL-2, XF-498, and HCT 15.
Archives of Pharmacal Research | 1997
Hee Jung Lee; Jee Hyung Jung; Sam Sick Kang; Jae Sue Choi
From the roasted seeds ofCassia tora L., a new naphthopyrone glycoside was isolated and characterized as 10-[(β-D-glucopyranosyl-(1→6)-O-β-D-glucopyranosyl)oxyl-5-hydroxy-8-methoxy-2-methyl-4H-naphtho [1,2-b]pyran-4-one(isorubrofusarin gentiobioside). Along with isorubrofusarin gentiobioside, alaternin and adenosine were isolated and identified.