Jee Young Kim

Extramammary Paget's Disease of External Genitalia with Bowenoid Features

Extramammary Pagets disease (EMPD) is an uncommon intraepithelial adenocarcinoma, primarily affecting the apocrine-bearing skin. Bowen disease is an intraepithelial squamous cell carcinoma having the potential to become invasive carcinoma. The histopathological concomitant features between EMPD and Bowen disease have been described. One theory is that primary EMPD arises multicentrically, within the epidermis from the pluripotent stem cells. Herein, we describe a case of EMPD that had bowenoid features, and review the previous cases associated with the origin of EMPD.

A Case of Familial Comedonal Darier's Disease

Dariers disease is a genetic disorder of keratinization with autosomal dominant inheritance. Its appearance is usually in the form of greasy, crusted, keratotic yellow-brown papules and plaques found particularly on seborrheic areas of the body. However, there are some clinical variants showing atypical skin lesions. Here we report an unusual case of Dariers disease, which mainly showed prominent comedonal papules over the face.

Objective Evaluation of the Effect of Q-Switched Nd:YAG (532 nm) Laser on Solar Lentigo by Using a Colorimeter.

5. In this study, we used a colorimeter to accurately and objectively evaluate the efficacy and adverse effects of the QSNL (535 nm) laser for the treatment of solar lentigo. Twenty Korean volunteers with solar lentigines on the face were enrolled. Informed consent was obtained from the participants, and this clinical study was approved by the local institutional review board. We selected two prominent solar lentigines in each patient, and each patient received two sessions of 535 nm QSNL (Pastelle; WONTECH Co., Ltd., Daejeon, Korea) therapy at 4-week intervals. An additional 4-week followup period was conducted after the last treatment. All lentigines were treated with pulses of QSNL irradiation (20 ns pulse width, 0.7∼0.8 J/cm 2 energy, and 3∼4 mm

Co-infection of Scedosporium apiospermum and Mycobacterium chelonae in an immunocompetent host

A 75‐year‐old man presented with multiple, scaly, erythematous, grouped papules, nodules and plaques with tenderness ranging from the right forearm to hand dorsum and the right lower leg for 2–3 months. Five months prior to presentation, the patient had received an antibiotic skin test on his right forearm. Lesions appeared approximately 2–3 months after the antibiotic skin test, slowly progressing without clinical improvement. Culture for fungus on the right forearm revealed growth of Scedosporium apiospermum. The tissue acid‐fast bacilli (AFB) culture for the right forearm and right leg revealed growth of non‐tuberculous mycobacteria which was Mycobacterium chelonae, and subsequent tissue polymerase chain reaction of both sites reported positive signs of M. chelonae. On diastase periodic acid‐Schiff stain of the biopsy specimen of the right forearm, fungal hyphae were found while rod‐shaped bacilli could be seen in AFB stain for the biopsy specimen of the right leg. The patient was treated with oral clarithromycin and ciprofloxacin along with an oral antifungal agent for 13 weeks. After the treatment, the lesions subsided and left a scar. We report a rare case of co‐infection of S. apiospermum and M. chelonae in an immunocompetent host.

Topical tacrolimus does not negatively impact acute skin wound healing.

Despite the increasing use of topical tacrolimus, there is little information about its effect on skin wound healing. To determine effects on acute cutaneous wound healing, two full‐thickness skin wounds were imparted on the backs of 45 hairless mice, which were then divided into vehicle‐, topical tacrolimus‐ and topical steroid‐treated group. Each drug was topically applied once daily. The wound area was assessed by using dermoscopic images every two days after wounding. At 3, 7 and 11 days after wounding, 10 wounds in each group were collected for semi‐quantitative analysis of histological features including re‐epithelialization, polymorphonuclear leucocytes, fibroblasts and collagen. We also checked the mRNA expression levels of EGF, TGF‐β, TNF‐α and IL‐1α. While topical application of clobetasol propionate was found to delay re‐epithelialization and infiltration of polymorphonuclear leucocyte, topical treatment with tacrolimus showed patterns similar to that of the vehicle. In the tacrolimus‐treated group, mRNA expression levels of IL‐1α and TGF‐β were slightly decreased, while the others were similar with the vehicle‐treated group. Unlike steroid, topical tacrolimus, therefore, did not disturb the wound healing process in a murine skin wound model.

Concurrent Drug-Induced Linear Immunoglobulin A Dermatosis and Immunoglobulin A Nephropathy

Diseases associated with immunoglobulin A (IgA) antibody include linear IgA dermatosis, IgA nephropathy, Celiac disease, Henoch-Schönlein purpura, etc. Although usually idiopathic, IgA antibody is occasionally induced by drugs (e.g., vancomycin, carbamazepine, ceftriaxone, and cyclosporine), malignancies, infections, and other causes. So far, only a few cases of IgA bullous dermatosis coexisting with IgA nephropathy have been reported. A 64-year-old female receiving intravenous ceftriaxone and metronidazole for liver abscess had purpuric macules and papules on her extremities. One week later, she had generalized edema and skin rash with bullae and was diagnosed with concurrent linear IgA dermatosis and IgA nephropathy. After steroid treatment, the skin lesion subsided within two weeks, and kidney function slowly returned to normal. As both diseases occurred after a common possible cause, we predict their pathogeneses are associated.

Pigmented epithelioid melanocytoma developed in a patient with Becker nevus syndrome

1 Niiyama S, Satoh K, Kaneko S et al. Segmental neurofibromatosis. Acta Derm Venereol 2005; 85: 448–449. 2 Krishnan RS, Angel TA, Orengo IF et al. Bilateral segmental neurofibromatosis: a case report and review. Int J Dermatol 2001; 40: 409– 411. 3 López L, Dominguez M, Novales C et al. Segmental neurofibromatosis of facial localization. Int J Dermatol 2005; 44: 583–586. 4 Dang JD, Cohen PR. Segmental neurofibromatosis and malignancy. Skinmed 2010; 8: 156–159. 5 Tinschert S, Naumann I, Stegmann E et al. Segmental neurofibromatosis is caused by somatic mutation of the neurofibromatosis type 1 (NF1) gene. Eur J Hum Genet 2000; 8: 455–459.

Multiple traumatic neuromas after laser ablation treatment for viral warts

alized granuloma annulare following BCG vaccination, mimicking papular tuberculid. Eur J Dermatol 2011; 21: 1001–1002. 3 Lee SW, Cheong SH, Byun JY, Choi YW, Choi HY, Myung KB. Generalized granuloma annulare in infancy following bacillus calmette-guerin vaccination. Ann Dermatol 2011; 23: S319–S321. 4 Dahl MV, Ullman S, Goltz RW. Vasculitis in granuloma annulare: histopathology and direct immunofluorescence. Arch Dermatol 1977; 113: 463–467. 5 Yun JH, Lee JY, Kim MK, et al. Clinical and pathological features of generalized granuloma annulare with their correlation: a retrospective multicenter study in Korea. Ann Dermatol 2009; 21: 113–119.