Jeffrey A. Stone

The ability of tumor volume to predict local control in surgically treated squamous cell carcinoma of the supraglottic larynx

Pretreatment CT volumetric measurement of the primary tumor has been shown to be a predictor of local control in patients with laryngeal carcinoma treated with radiation therapy (RT) alone. A direct association has been demonstrated between tumor volume of supraglottic squamous cell carcinoma (SGSCCA) and local control. However, the association between tumor volume of SGSCCA and local control has not been investigated in patients treated surgically. The purpose of this study was to determine the relationship between SGSCCA tumor volume and local control in patients treated surgically.

3D Graph Description of the Intracerebral Vasculature from Segmented MRA and Tests of Accuracy by Comparison with X-ray Angiograms

This paper describes largely automated methods of creating connected, 3D vascular trees from individual vessels segmented from magnetic resonance angiograms. Vessel segmentation is initiated by user-supplied seed points, with automatic calculation of vessel skeletons as image intensity ridges and automatic estimation of vessel widths via medialness calculations. The tree-creation process employs a variant of the minimum spanning tree algorithm and evaluates image intensities at each proposed connection point. We evaluate the accuracy of nodal connections by registering a 3D vascular tree with 4 digital subtraction angiograms (DSAs) obtained from the same patient, and by asking two neuroradiologists to evaluate each nodal connection on each DSA view. No connection was judged incorrect. The approach permits new, clinically useful visualizations of the intracerebral vasculature.

Normal canals at the fundus of the internal auditory canal: CT evaluation.

PURPOSE Knowledge of the normal anatomy of the four bony canals located at the fundus of the internal auditory canal (IAC) is necessary during evaluation of temporal bone trauma, congenital anomalies affecting the individual nerves, and some neuro-otologic surgeries. The purpose of this work was therefore to characterize the normal appearance of the four bony canals and to measure their dimensions. METHOD A retrospective study was performed using CT studies of the temporal bones in 50 patients to identify and characterize the bony canals for the labyrinthine segment of the facial nerve (BCFN), superior vestibular nerve (BCSVN), cochlear nerve (BCNC), and the inferior vestibular nerve (singular canal; SC) located at the fundus of the IAC. All the patients underwent high resolution temporal bone CT for evaluation of uncomplicated inflammatory (n = 49) and neoplastic (n = 1) diseases involving the temporal bone. CT studies were done using 1-mm-thick contiguous sections in axial and coronal planes. Measurements of the canals were performed by one radiologist. No patient had a prior history of trauma, vertigo, and sensorineural hearing loss or facial nerve paralysis. RESULTS The BCFN, BCSVN, and BCNC were identified in all studies, whereas the SC was seen in 93% of studies. The BCFN, BCSVN, and BCNC arise from the fundus of the IAC, whereas the SC arises medial to the fundus. Mean +/- SD measurements (in mm) of the length and width were as follows: BCFN = 2.92+/-0.48 and 0.91+/-0.28; BCSVN = 2.36+/-0.53 and 0.89+/-0.28; BCNC = 0.93+/-0.21 and 2.13+/-0.44; and SC = 3.22+/-0.73 and 0.50+/-0.14. CONCLUSION These small canals are routinely visualized on thin section (1 mm) CT of the temporal bone and should not be confused with fractures. This study provides baseline measurements that may be used to evaluate congenital anomalies of these canals. These data may also be helpful in the presurgical evaluation of patients undergoing singular neurectomies for benign positional vertigo.

Leukoencephalopathy complicating an Ommaya reservoir and chemotherapy

Abstract We describe the imaging findings in an unusual case of biopsy-proven, methotrexate-induced leukoencephalopathy complicating a malfunctioning Ommaya reservoir in a patient with lymphoma.

MRI in 3-methylglutaconic aciduria type 1.

Abstract MRI in a young child with 3-methylglutaconic aciduria type 1 showed signal abnormalities in the basal ganglia which progressed despite successful treatment.