Jeffrey D. Wardell

Positive alcohol expectancies mediate the influence of the behavioral activation system on alcohol use: a prospective path analysis.

Grays (1975, 1987) behavioral activation (BAS) and behavioral inhibition systems (BIS) are thought to underlie sensitivity to reinforcement and punishment, respectively. Consistent with Grays theory and the Acquired Preparedness model, BAS may facilitate the learning of positive alcohol expectancies (PAEs) over time, leading to increases in drinking. Yet, no prospective tests of this pathway have been reported. The present study investigated whether BAS prospectively predicted PAEs and whether PAEs mediated the association between BAS and subsequent alcohol use. We hypothesized that BAS would influence drinking specifically via enhancement-related PAEs. We also explored the role of BIS in PAEs and drinking. College students (N=557) completed online BAS, PAE, and alcohol use measures in September of their first (T1), second (T2), and third (T3) years of college. We conducted autoregressive path analyses with three BAS subscales and BIS (T1) as predictors, four PAE types (T2) as mediators, and quantity and frequency of drinking (T3) as outcomes. The BAS Fun-Seeking scale was prospectively associated with PAEs, and there was a significant indirect path from Fun-Seeking to alcohol use mediated specifically through activity enhancement PAEs. BIS was positively associated with some PAE types, but did not have indirect effects on drinking. Findings are consistent with both the theory of the BAS and the Acquired Preparedness model, as individuals high on BAS Fun-Seeking may find the rewarding properties of alcohol more reinforcing, leading to stronger enhancement PAEs and increased drinking over time. The prospective design helps establish the temporal association between BAS and alcohol-related learning, and points to the need for prevention efforts that target these at-risk students.

Coping, PTSD symptoms, and alcohol involvement in trauma-exposed college students in the first three years of college.

The objective of the present study was to examine prospective, bidirectional associations among posttraumatic stress disorder (PTSD) symptoms, coping style, and alcohol involvement (use, consequences) in a sample of trauma-exposed students just entering college. We also sought to test the mechanistic role that coping may play in associations between PTSD symptoms and problem alcohol involvement over time. Participants (N = 734) completed measures of trauma exposure, PTSD symptoms, coping, and alcohol use and consequences in September of their first college year and again each September for the next 2 years. We observed reciprocal associations between PTSD and negative coping strategies. In our examination of a mediated pathway through coping, we found an indirect association from alcohol consequences and PTSD symptoms via negative coping, suggesting that alcohol consequences may exacerbate posttraumatic stress over time by promoting negative coping strategies. Trauma characteristics such as type (interpersonal vs. noninterpersonal) and trauma reexposure did not moderate these pathways. Models were also invariant across gender. Findings from the present study point to risk that is conferred by both PTSD and alcohol consequences for using negative coping approaches, and through this, for posttraumatic stress. Interventions designed to decrease negative coping may help to offset this risk, leading to more positive outcomes for those students who enter college with trauma exposure.

Drinking consequence types in the first college semester differentially predict drinking the following year

The objectives of the present study were to examine the utility of distinguishing among negative consequence types when seeking to predict drinking later in college, to understand which consequences in particular were associated with future drinking, and to determine the direction of those associations. We also examined whether there were differences in the types of drinking outcomes (quantity, frequency, binge) predicted by unique consequences. Finally, we tested whether the link between consequences and future drinking was different for men versus for women. Incoming first year college students (n=997; 65% female) completed an online assessment in September of the first college year, and again at the same time the following year. Results of structural equation model tests offered support for the utility of distinguishing among different consequence types, as specific consequences experienced during the first semester of college were associated differently with drinking at the beginning of the second school year. Gender differences also were observed. For both men and women, social consequences were associated with increases in drinking over time. Blackout drinking also evidenced prospective prediction, but differentially for men and women. For men, these consequences were associated with later increases in drinking, whereas for women, they were associated with a diminution in drinking the next year. For men, only consequences associated with self-care (impairment in physical activity, physical appearance, less time to pursue recreation) predicted decreases in drinking at Year 2. Prediction was generally similar across drinking outcomes. Results suggest that whether negative consequences result in downward titration, escalation, or no change at all in later drinking depends on the type of consequence experienced, and who experiences it.

Alcohol expectancies, perceived norms, and drinking behavior among college students: examining the reciprocal determinism hypothesis.

Social learning mechanisms, such as descriptive norms for drinking behavior (norms) and positive alcohol expectancies (PAEs), play a major role in college student alcohol use. According to the principle of reciprocal determinism (Bandura, 1977), norms and PAEs should be reciprocally associated with alcohol use, each influencing one another over time. However, the nature of these prospective relationships for college students is in need of further investigation. This study provided the first examination of the unique reciprocal associations among norms, PAEs, and drinking together in a single model. PAEs become more stable with age, whereas norms are likely to be more dynamic upon college entry. Thus, we hypothesized that alcohol use would show stronger reciprocal associations with norms than with PAEs for college students. Students (N = 557; 67% women) completed online measures of PAEs, norms, and quantity and frequency of alcohol use in September of their first (T1), second (T2), and third (T3) years of college. Reciprocal associations were analyzed using a cross-lagged panel design. PAEs had unidirectional influences on frequency and quantity of alcohol use, with no prospective effects from alcohol use to PAEs. Reciprocal associations were observed between norms and alcohol use, but only for quantity and not for frequency. Specifically, drinking quantity prospectively predicted quantity norms and quantity norms prospectively predicted drinking quantity. This effect was observed across both years in the model. These findings support the reciprocal determinism hypothesis for norms but not for PAEs in college students and may help to inform norm-based interventions.

Mood and Implicit Alcohol Expectancy Processes: Predicting Alcohol Consumption in the Laboratory

BACKGROUND Implicit positive alcohol expectancy (PAE) processes are thought to respond phasically to external and internal stimuli-including mood states-and so they may exert powerful proximal influences over drinking behavior. Although social learning theory contends that mood states activate mood-congruent implicit PAEs, which in turn lead to alcohol use, there is a dearth of experimental research examining this mediation model relative to observable drinking. Moreover, an expectancy theory perspective might suggest that, rather than influencing PAEs directly, mood may moderate the association between PAEs and drinking. To test these models, this study examined the role of mood in the association between implicitly measured PAE processes (i.e., latency to endorse PAEs) and immediate alcohol consumption in the laboratory. Gender differences in these processes also were examined. METHOD College students (N = 146) were exposed to either a positive, negative, or neutral mood induction procedure, completed a computerized PAE reaction time (RT) task, and subsequently consumed alcohol ad libitum. RESULTS The mood manipulation had no direct effects on drinking in the laboratory, making the mediation hypothesis irrelevant. Instead, gender and mood condition moderated the association between RT to endorse PAEs and drinking in the laboratory. For males, RT to tension reduction PAEs was a stronger predictor of volume of beer consumed and peak blood alcohol concentration in the context of general arousal (i.e., positive and negative mood) relative to neutral mood. RT to PAEs did not predict drinking in the laboratory for females. CONCLUSIONS The results show that PAE processes are important determinants of immediate drinking behavior in men, suggesting that biased attention to mood-relevant PAEs-as indicated by longer RTs-predicts greater alcohol consumption in the appropriate mood context. The findings also highlight the need to consider gender differences in PAE processes. This study underscores the need for interventions that target automatic cognitive processes related to alcohol use.

Reciprocal associations between PTSD symptoms and alcohol involvement in college: a three-year trait-state-error analysis.

Bidirectional associations between posttraumatic stress disorder (PTSD) symptoms and alcohol involvement have been theorized, but have not been tested empirically. In this study, we examined these relations at the transition into and over the first 3 years of college by using an analytic approach (Trait-State-Error Modeling [TSE]; Kenny & Zautra, 1995) that allowed us to examine prospective, reciprocal associations among these constructs while accounting for intraindividual stability. Young adults (N = 486) were recruited at matriculation into college and assessed by Web survey in September of the first college year (T1) and 11 additional time points over 3 years. Findings showed evidence of prospective associations from alcohol involvement (both use and problems) to PTSD symptoms over the 3-year assessment period. We also observed prospective relations from PTSD symptoms to alcohol involvement over time. Patterns of covariation in trait vulnerability for alcohol involvement and PTSD symptoms differed from crossed-lagged associations among state-like variance in these constructs. Results suggest that PTSD symptoms and alcohol involvement each predict the other over the course of college. Findings also highlight the importance of considering both time-varying and stable sources of variation in these associations.

Negative urgency mediates the relationship between childhood maltreatment and problems with alcohol and cannabis in late adolescence

BACKGROUND Childhood maltreatment is an important risk factor for problems with alcohol and other drugs such as cannabis. Although this link has been well established, the mechanisms in this association require further study. High levels of impulsivity and difficulties with emotion regulation are often associated with childhood maltreatment. Negative urgency--an emotion-based facet of impulsivity--is a strong predictor of substance use problems and may be a particularly relevant facet of impulsivity in the link between childhood maltreatment and alcohol and cannabis outcomes. However, few studies have examined the specific mediational pathway from childhood maltreatment to alcohol and cannabis problems through negative urgency. OBJECTIVES We tested the hypothesis that the associations between history of childhood maltreatment and current alcohol and cannabis problems would be mediated by negative urgency, but not other facets of impulsivity. METHODS Participants (N=232), who were in late adolescence (mean age=19.75), completed self-report measures of different facets of impulsivity, past childhood maltreatment, and current alcohol and cannabis use and problems. RESULTS In analyses including several facets of impulsivity as simultaneous mediators, negative urgency was the only facet to mediate the associations of childhood maltreatment severity with alcohol and cannabis problems. CONCLUSIONS These findings provide support for negative urgency as a unique mediator of the associations between childhood maltreatment and both alcohol and cannabis problems, suggesting that future work on mechanisms in these associations should focus on mood-based impulsivity.

Application of an alcohol clamp paradigm to examine inhibitory control, subjective responses, and acute tolerance in late adolescence.

Individual differences in acute alcohol effects on cognitive control and subjective responses--and acute tolerance to these effects--are implicated in the risk for heavy drinking and alcohol-related harms. Few studies have examined these effects in drinkers under age 21. Additionally, studies of acute tolerance typically involve bolus oral alcohol administration, such that estimates of tolerance are confounded with blood alcohol concentration (BAC) limb. The current study examined cognitive control and subjective responses in young heavy drinkers (n = 88; M = 19.8 years old, SD = 0.8) during a single-session alcohol clamp protocol. Participants completed an intravenous alcohol session comprising an ascending limb (0 to 80 mg% in 20 min) and a BAC plateau (80 mg% for 80 min). Serial assessments included a cued go/no-go task and measures of stimulation, sedation, and craving. Relevant individual difference factors (attention-deficit hyperactivity disorder [ADHD] symptoms and sensation seeking) were examined as moderators. Multilevel modeling demonstrated that response inhibition worsened following initial rise in BAC and showed increasing impairment during the BAC plateau. ADHD symptoms and sensation seeking moderated this effect. Significant within-person associations between stimulation and craving were evident on the ascending limb only. Participants with higher ADHD symptoms reported steeper increases in stimulation during the ascending limb. These findings provide initial information about subjective and behavioral responses during pseudoconstant BAC, and potential moderators of these outcomes, in late adolescence. Additional studies with placebo-controlled designs are necessary to confirm these findings.

Is expectancy reality? Associations between tension reduction beliefs and mood following alcohol consumption

The present study investigated whether tension reduction expectancies were uniquely associated with self-reported mood following in-lab alcohol administration, given that little research has addressed this association. We also tested whether level of experience with alcohol, which may influence the learning of expectancies, moderated expectancy-mood associations. Regularly drinking college students (N = 145) recruited through advertisements completed self-report measures of positive alcohol expectancies, alcohol involvement, demographics, and pre- and post-drinking mood, and then consumed alcohol ad libitum up to four drinks in the laboratory. Regression analyses controlling for pre-consumption mood, blood alcohol concentration, and all other positive expectancies showed tension reduction expectancies to be a marginally significant positive predictor of negative mood post-drinking. This association was significant only for those who achieved lower blood alcohol concentrations in lab and those who reported less involvement with alcohol (i.e., lower typical quantity, heavy episodic drinking frequency, and years of regular drinking). Findings suggest that associations between expectations for mood and actual post-drinking mood outcomes may operate differently for less versus more involved drinkers. Clinical implications pertain to early intervention, when expectancies may be less ingrained and perhaps more readily modified.

Motivational pathways from reward sensitivity and punishment sensitivity to gambling frequency and gambling-related problems.

Motives for gambling have been shown to have an important role in gambling behavior, consistent with the literature on motives for substance use. While studies have demonstrated that traits related to sensitivity to reward (SR) and sensitivity to punishment (SP) are predictive of substance use motives, little research has examined the role of these traits in gambling motives. This study investigated motivational pathways from SR and SP to gambling frequency and gambling problems via specific gambling motives, while also taking into account history of substance use disorder (SUD). A community sample of gamblers (N = 248) completed self-report questionnaires assessing SR, SP, gambling frequency, gambling-related problems, and motives for gambling (social, negative affect, and enhancement/winning motives). Lifetime SUD was also assessed with a structured clinical interview. The results of a path analysis showed that SR was uniquely associated with all 3 types of gambling motives, whereas SP and SUD were associated with negative affect and enhancement/winning motives but not social motives. Also, both negative affect and enhancement/winning motives were associated with gambling problems, but only enhancement/winning motives were significantly related to gambling frequency. Analyses of indirect associations revealed significant indirect associations from SR, SP, and SUD to gambling frequency mediated through enhancement/winning motives and to gambling problems mediated through both negative affect and enhancement/winning motives. The findings highlight the importance of SR and SP as independent predictors of gambling motives and suggest that specific motivational pathways underlie their associations with gambling outcomes.